Results 1 to 10 of about 571,778 (317)

TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging

Skeletal Muscle
Background Enzymes of the Ten-Eleven Translocation family are responsible for 5-methylcytosine (5mC) oxidation and play a key role in regulating DNA demethylation during various developmental processes, including myogenesis.
Vincent Gerdy, Emilie Plantié, Romane Bertrand, Yoan Renaud, Guillaume Junion, Laurence Vandel, Lucas Waltzer   +6 more
doaj   +1 more source

PPARδ regulates satellite cell proliferation and skeletal muscle regeneration

Skeletal Muscle, 2011
Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that play important roles in development and energy metabolism. Whereas PPARδ has been shown to regulate mitochondrial biosynthesis and slow-muscle fiber types, its ...
Angione Alison R, Jiang Chunhui, Pan Dongning, Wang Yong-Xu, Kuang Shihuan   +4 more
doaj   +1 more source

GsMTx4-blocked PIEZO1 channel promotes myogenic differentiation and alleviates myofiber damage in Duchenne muscular dystrophy

Skeletal Muscle
Background Duchenne muscular dystrophy (DMD) is a debilitating disease characterized by progressive muscle-wasting and a lack of effective therapy. Although the application of GsMTx4 has been shown to reduce muscle mass loss in dystrophic mice, the ...
Wengang Wang, Mingyang Huang, Xiusheng Huang, Ke Ma, Ming Luo, Ningning Yang   +5 more
doaj   +1 more source

mTORC2 affects the maintenance of the muscle stem cell pool

Skeletal Muscle, 2019
Background The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, PKC, and SGK.
Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard, Markus A. Rüegg   +5 more
doaj   +1 more source

Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

Skeletal Muscle, 2020
Background Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leading to delayed milestones, and ...
Pamela Barraza-Flores, Hailey J. Hermann, Christina R. Bates, Tyler G. Allen, Timothy T. Grunert, Dean J. Burkin   +5 more
doaj   +1 more source

Myoblast fusion confusion: the resolution begins

Skeletal Muscle, 2018
The fusion of muscle precursor cells is a required event for proper skeletal muscle development and regeneration. Numerous proteins have been implicated to function in myoblast fusion; however, the majority are expressed in diverse tissues and regulate ...
Srihari C. Sampath, Srinath C. Sampath, Douglas P. Millay   +2 more
doaj   +1 more source

Surgical fatigue syndrome and EDiS3 intervention, should every surgeon need to know how to mitigate muscle skeletal discomfort? [PDF]

Surg Open Sci, 2023
Chávez-Saavedra G, Espinosa-Hinojosa A, Colonna-Márquez LE, Hidalgo-Valadez C, Díaz-Martínez DA, González-Sandoval BV.   +5 more
europepmc   +1 more source

Author Correction: Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice

Scientific Reports, 2021
Henan Zhao, Bevan M. Lewellen, Rebecca J. Wilson, Di Cui, Joshua C. Drake, Mei Zhang, Zhen Yan   +6 more
doaj   +1 more source

Level of muscle regeneration in limb-girdle muscular dystrophy type 2I relates to genotype and clinical severity

Skeletal Muscle, 2011
Background The balance between muscle regeneration and ongoing degeneration is a relationship that greatly influences the progression of muscular dystrophy.
Krag Thomas O, Hauerslev Simon, Sveen Marie, Schwartz Malene, Vissing John   +4 more
doaj   +1 more source

Combination of denosumab and biologic DMARDs in inflammatory muscle-skeletal diseases and connective tissue diseases. [PDF]

Eur J Rheumatol, 2021
Bruni C, Cigolini C, Tesei G, Cometi L, Bartoli F, Fiori G, Nacci F, Bellando-Randone S, Guiducci S, Matucci-Cerinic M.   +9 more
europepmc   +1 more source