Results 31 to 40 of about 1,470,518 (253)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Nicotinamide phosphoribosyltransferase (Nampt) in Lateral Hypothalamus Maintains Skeletal Muscle Functions Through Lactate‐Mediated Calcium Signalling in Male Mice

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia has become an urgent socioeconomic problem in rapidly aging societies. The pathogenesis of age‐associated sarcopenia is not fully understood and no effective therapeutic strategies have been developed to date.
Takahiro Eguchi, Keiko Kabetani, Naoki Ito   +2 more
doaj   +1 more source

Diversification of the muscle proteome through alternative splicing

Skeletal Muscle, 2018
Background Skeletal muscles express a highly specialized proteome that allows the metabolism of energy sources to mediate myofiber contraction. This muscle-specific proteome is partially derived through the muscle-specific transcription of a subset of ...
Kiran Nakka, Claudia Ghigna, Davide Gabellini, F. Jeffrey Dilworth   +3 more
doaj   +1 more source

Function of mTOR complex 1 and 2 in skeletal muscle [PDF]

, 2009
Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice

Journal of Sport and Health Science
Background: Exercise is an effective intervention for obesity and type 2 diabetes, with significant physiological benefits over pharmacological interventions.
Robert J. Shute, Ryan N. Montalvo, Wenqing Shen, Yuntian Guan, Qing Yu, Mei Zhang, Zhen Yan   +6 more
doaj   +1 more source

SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes

Skeletal Muscle, 2017
Background Facioscapulohumeral muscular dystrophy (FSHD) is in most cases caused by a contraction of the D4Z4 macrosatellite repeat on chromosome 4 (FSHD1) or by mutations in the SMCHD1 or DNMT3B gene (FSHD2).
Amanda G. Mason, Roderick C. Slieker, Judit Balog, Richard J. L. F. Lemmers, Chao-Jen Wong, Zizhen Yao, Jong-Won Lim, Galina N. Filippova, Enrico Ne, Rabi Tawil, Bas T. Heijmans, Stephen J. Tapscott, Silvère M. van der Maarel   +12 more
doaj   +1 more source

Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes [PDF]

, 2012
Muscle-derived nitric oxide (NO) mediates fundamental physiological actions on skeletal muscle including glucose uptake into muscle cells. Recently, we have shown that the altered glucose metabolism in skeletal muscle of patients with type 2 diabetes ...
Karla Punkt, Volker Adams, Katharina Kandt, Matthias Blueher, Andreas Oberbach, Igor Buchwalow   +5 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency [PDF]

, 2010
Skeletal muscle contraction increases energy expenditure and improves metabolic flexibility, but is also a key regulator of metabolic gene expression.
Carson, Brian
core   +2 more sources