Results 61 to 70 of about 1,819,951 (268)

The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle

Scientific Reports, 2018
p53 plays an important role in regulating mitochondrial homeostasis. However, it is unknown whether p53 is required for the physiological and mitochondrial adaptations with exercise training.
Kaitlyn Beyfuss, Avigail T. Erlich, Matthew Triolo, David A. Hood   +3 more
doaj   +1 more source

A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner

Nature Communications, 2020
Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport.
In-Gyun Lee, Sydney E. Cason, Saif S. Alqassim, Erika L. F. Holzbaur, Roberto Dominguez   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Muscle Differentiation: A Gene for Slow Muscle? [PDF]

Current Biology, 2004
Skeletal muscle comes in two fundamental flavours, slow and fast, which determine physiological performance. Zebrafish screens have provided a handle on the molecular mechanism driving slow muscle formation. The transcriptional repressor Blimp1 has now been shown to be required in embryonic slow muscle precursor cells.
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Typical CIDP, distal variant CIDP, and anti-MAG antibody neuropathy: An ultra-high frequency ultrasound comparison of nerve structure

Scientific Reports
To date, little is known about the usefulness of ultra-high frequency ultrasound (UHF-US, 50–70 MHz) in clinical practice for the diagnosis of dysimmune neuropathies.
Angela Puma, Nicolae Grecu, Raluca Ș. Badea, Adeline Morisot, Roxana Zugravu, Mihai B. Ioncea, Michele Cavalli, Oana Lăcătuș, Andra Ezaru, Chorfa Hacina, Luisa Villa, Charles Raffaelli, Nicolas Azulay, Sabrina Sacconi   +13 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation

Skeletal Muscle
Background Muscle atrophy is a common consequence of the loss of innervation and is accompanied by mitochondrial dysfunction. Mitophagy is the adaptive process through which damaged mitochondria are removed via the lysosomes, which are regulated in part ...
Ashley N. Oliveira, Jonathan M. Memme, Jenna Wong, David A. Hood   +3 more
doaj   +1 more source

O-GlcNAcylation, contractile protein modifications and calcium affinity in skeletal muscle

Frontiers in Physiology, 2014
Phosphorylation is recognized as being one of the major post-translational modification involved in the fine modulation of all if not all cellular processes including skeletal muscle contractile activity.
Caroline eCieniewski-Bernard, Matthias eLambert, Erwan eDupont, Valerie eMontel, Laurence eStevens, Bruno eBastide   +5 more
doaj   +1 more source

Mepivacaine reduces calcium transients in isolated murine ventricular cardiomyocytes

BMC Anesthesiology, 2020
Background The potential mechanism of mepivacaine’s myocardial depressant effect observed in papillary muscle has not yet been investigated at cellular level.
Matias Mosqueira, Güçlü Aykut, Rainer H. A. Fink   +2 more
doaj   +1 more source