Results 81 to 90 of about 2,741,127 (298)
Muscle Development: Making Drosophila muscle [PDF]
Current Biology, 1995 Analysis of flies with mutations in the gene encoding the D-mef2 transcription factor identifies it as a controller of differentiation in multiple muscle cell types; it is the first such gene to be described.
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contractility and results in postnatal death in mice [PDF]
, 2008 The smooth muscle myosin heavy chains (SMHC) are motor proteins powering smooth muscle contraction. Alternate splicing of SHMC gene at the C-terminus produces SM1, and SM2 myosin isoforms; SM2 (200 kDa) contains a unique 9-amino-acid sequence at the ...
Mei Chi +4 more
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Noninvasive Estimation of Myosin Heavy Chain Composition in Human Skeletal Muscle [PDF]
, 2011 Purpose: Information on muscle fiber type composition is of great importance in muscle physiology and athletic performance. Because there are only a few techniques available that noninvasively and accurately provide an estimate of muscle fiber type ...
Rittweger, Jörn +17 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Sleep is of the muscle, by the muscle, and for the muscle
SLEEP, 2023 Brager, Allison J, Paul, Ketema N
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Muscle Spindles in Phasic and Tonic Muscle
The Tohoku Journal of Experimental Medicine, 1964 Comparisons were made of muscle spindle structure between phasic and tonic muscles stained by the gold chloride method. The most significant difference was in the ring diameter of the sensory nerve terminals wrapped around the nuclear bags. In tibialis anterior it was largest, in gastrocnemius intermediate, and in soleus smallest.
Honma, Saburo, Seki, Yasuo
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Effects of Rosa damascena and its compounds on smooth muscle contractility
Rosa damascena, a member of the Rosaceae family, is an ancient holy plant. This ornamental plant is famous for its beneficial effects. R. damascena has been used as a traditional medicinal plant since ancient times because of its therapeutic activity ...
Sinag, Ipek Nazli, Demirel, Sadettin
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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