Results 71 to 80 of about 2,741,127 (298)

Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats

FACETS, 2022
Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cultured myocytes
Haiyan Wang, Amy Zheng, Edward B. Arias, Gregory D. Cartee   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury

BMC Medicine
Background Musculoskeletal injuries comprise a growing source of disability worldwide, and the recovery of muscle strength following injury is a critical determinant of patient reported outcomes.
Alexander R. Keeble, Allison M. Owen, Nicholas T. Thomas, Sara Gonzalez-Velez, Camille R. Brightwell, Tyler Barnes, Douglas E. Long, Philip A. Kern, Caitlin E. Conley, Austin V. Stone, Darren L. Johnson, Yuan Wen, Brian Noehren, Christopher S. Fry   +13 more
doaj   +1 more source

Skeletal muscle mTORC1 regulates whole-body metabolism [PDF]

, 2015
Skeletal muscle, which represents over 40% of the total body mass, is a dynamic tissue with a key role in the maintenance of metabolic homeostasis. Several lines of evidence indicate that alterations of the normal muscle function, as for example in ...
Ormazabal, Maitea Guridi
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Targeting the IRE1α-XBP1 signaling axis impairs tumor growth and promotes myogenic differentiation in rhabdomyosarcoma

Communications Biology
Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma arising from mesenchymal progenitors with skeletal muscle features. The unfolded protein response (UPR) maintains proteostasis during endoplasmic reticulum stress, with the IRE1α-XBP1 axis ...
Anh Tuan Vuong, Aniket S. Joshi, Phuong T. Ho, Meiricris Tomaz da Silva, Bin Guo, Meghana V. Trivedi, Ashok Kumar   +6 more
doaj   +1 more source

Muscle fatigue, bioenergetic responses and metabolic economy during load‐ and velocity‐based maximal dynamic contractions in young and older adults

Physiological Reports, 2023
We evaluated whether task‐dependent, age‐related differences in muscle fatigue (contraction‐induced decline in normalized power) develop from differences in bioenergetics or metabolic economy (ME; mass‐normalized work/mM ATP).
Liam F. Fitzgerald, Miles F. Bartlett, Jane A. Kent   +2 more
doaj   +1 more source

Respiratory muscle work and inspiratory muscle training on cytokines, oxidative stress and diaphragm fatigue in younger and older populations [PDF]

, 2013
Increased respiratory muscle work is encountered during strenuous whole-body exercise, and at rest in older adults and those with pulmonary limitations such as chronic obstructive pulmonary disease (COPD).
Mills, DE
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An ultrasound and shear wave elastography study: effect of grip on medial elbow joint morphology during valgus stress

BMC Musculoskeletal Disorders
Background The flexor pronator mass (FPM) is an important dynamic stabilizer to valgus stress at the elbow and has been reported to protect against ulnar collateral ligament (UCL) injury.
Matthew F. Gong, Tyler J. Wilps, Jamieson G. Abrams, Shanelle Dorn, Jesal N. Parekh, Tudor H. Hughes, Catherine M. Robertson, Matthew J. Meunier, Samuel R. Ward   +8 more
doaj   +1 more source