Results 11 to 20 of about 19,108 (217)
FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy [PDF]
FEBS Open Bio, 2015 Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function.
Jen Y. Lee +3 more
doaj +2 more sources
The C313Y Piedmontese mutation decreases myostatin covalent dimerisation and stability [PDF]
BMC Research Notes, 2011 Background Myostatin is a key negative regulator of muscle growth and development, whose activity has important implications for the treatment of muscle wastage disorders.
Starck Carlene S +1 more
doaj +2 more sources
Myostatin in tendon maintenance and repair
Growth Factors, 2009 Myostatin, a negative regulator of muscle growth, has recently been found to be expressed in tendons. Myostatin-deficient mice have weak and brittle tendons, which suggest that myostatin could be important for tendon maintenance. Follistatin expression in the callus tissue after tendon transection is influenced by loading.
Pernilla, Eliasson +4 more
openaire +3 more sources
Myostatin-like proteins regulate synaptic function and neuronal morphology. [PDF]
, 2017 Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass.
HM Cochemé (7756604) +10 more
core +8 more sources
Myostatin: Biology and Clinical Relevance
Mini-Reviews in Medicinal Chemistry, 2006 Myostatin is a negative regulator of muscle mass. Important advances in our understanding of the complex biology of this factor have revealed the therapeutic potential of antagonizing the myostatin pathway. Here we present the rationale for evaluating anti-myostatin therapies in human muscle-wasting disorders.
Carnac, Gilles +3 more
openaire +3 more sources
Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy. [PDF]
Exp PhysiolAbstract Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass and function.
Nieuwenhuijsen DHC +2 more
europepmc +2 more sources
Circulation, 2010 Cachexia in chronic heart failure (HF) is a major clinical problem that is still underestimated for its impact on morbidity, mortality, and healthcare expenditures. The pathophysiology of cardiac cachexia is characterized by a catabolic/anabolic imbalance.
Springer, Jochen +2 more
openaire +2 more sources
Biomolecules, 2020 Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size.
Juulia H. Lautaoja +5 more
doaj +1 more source
Serum myostatin is reduced in individuals with metabolic syndrome. [PDF]
PLoS ONE, 2014 Myostatin is a negative regulator of skeletal muscle mass and may also modulate energy metabolism secondarily. We aim to investigate the relationship between serum myostatin and the metabolic variables in diabetic (DM) and non-diabetic subjects.A cross ...
Der-Sheng Han +7 more
doaj +1 more source
Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Frontiers in Physiology, 2022 Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target.
Mohammad Hassan Baig +18 more
openaire +4 more sources