Results 21 to 30 of about 12,955 (195)
Frontiers in Immunology, 2017 Rheumatoid arthritis (RA) is characterized by the infiltration of a number of pro-inflammatory cytokines into synovial fluid and patients with RA often develop joint destruction and deficits in muscle mass.
Sung-Lin Hu +12 more
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Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways. [PDF]
PLoS ONE, 2007 Myostatin is a transforming growth factor-beta family member that normally acts to limit skeletal muscle growth. Mice genetically engineered to lack myostatin activity have about twice the amount of muscle mass throughout the body, and similar effects ...
Se-Jin Lee
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Deciphering Myostatin’s Regulatory, Metabolic, and Developmental Influence in Skeletal Diseases
Frontiers in Genetics, 2021 Current research findings in humans and other mammalian and non-mammalian species support the potent regulatory role of myostatin in the morphology and function of muscle as well as cellular differentiation and metabolism, with real-life implications in ...
Catherine L. Omosule +2 more
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npj Microgravity, 2023 Novel treatments for muscle wasting are of significant value to patients with disease states that result in muscle weakness, injury recovery after immobilization and bed rest, and for astronauts participating in long-duration spaceflight.
Andrea M. Hanson +6 more
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Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide [PDF]
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2016 Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth, and its activity is suppressed by MSTN propeptide (MSTNpro), the N-terminal part of MSTN precursor cleaved during post-translational MSTN processing. The current study examined which region of flatfish (Paralichthys olivaceus) MSTN-1 propeptide (MSTN1pro) is critical for MSTN ...
Sang Beum, Lee +4 more
openaire +2 more sources
The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy. [PDF]
PLoS ONE, 2015 Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating ...
Yutaka Ohsawa +11 more
doaj +1 more source
Aging, 2014 The aging of a multicellular organism is an intricate process that results from signaling events and age-related degeneration in cells, tissues, and organ systems. Studies in model organisms have provided evidence of unanticipated connection between local and systemic aging [1]. Research in this field is defining the key tissues that govern an organism'
Vishal K, Patel, Fabio, Demontis
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Serum myostatin levels are associated with abdominal aortic calcification in dialysis patients
Kidney Research and Clinical Practice, 2019 Background : Serum myostatin levels are increased according to renal function decline and myostatin may be a main mediator of chronic kidney disease–related sarcopenia.
Su Mi Lee +5 more
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Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
BMC Research Notes, 2010 Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with
Cheng Ye +2 more
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Association between serum GDF-15, myostatin, and sarcopenia in cardiovascular surgery patients
International Journal of Cardiology: Heart & Vasculature, 2022 Background: Myostatin is a negative regulator of skeletal muscle mass. On the other hand, growth differentiation factor (GDF)-15 is associated with lower muscle strength and muscle mass.
Riichi Nishikawa +13 more
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