Results 21 to 30 of about 19,108 (217)

Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients. [PDF]

PLoS ONE, 2013
BACKGROUND: Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary ...
Astrid Breitbart, Gesine M Scharf, David Duncker, Christian Widera, Jens Gottlieb, Arndt Vogel, Sebastian Schmidt, Gudrun Brandes, Hans-Gert Heuft, Ralf Lichtinghagen, Tibor Kempf, Kai C Wollert, Johann Bauersachs, Joerg Heineke   +13 more
doaj   +1 more source

La myostatine [PDF]

Les Cahiers de Myologie, 2016
L’unique modele murin reproduisant la myopathie centronucleaire autosomique dominante associe a une mutation du gene dynamine -2 (KI-dnm2 R465W/+ ) reproduit la plupart des signes cliniques observes chez l’Homme, notamment une atrophie et une perte de force musculaire.
David Arnould, Anne-Cécile Durieux
openaire   +1 more source

Low Myostatin Serum Levels Are Associated with Poor Outcome in Critically Ill Patients

Diagnostics, 2020
Background: Growth differentiation factor 8, GDF-8 (Myostatin), is a protein released by myocytes inhibiting muscle growth and differentiation. Serum concentrations of Myostatin can predict poor survival in different chronic diseases, but its role in ...
Theresa H. Wirtz, Sven H. Loosen, Lukas Buendgens, Berkan Kurt, Samira Abu Jhaisha, Philipp Hohlstein, Jonathan F. Brozat, Ralf Weiskirchen, Tom Luedde, Frank Tacke, Christian Trautwein, Christoph Roderburg, Alexander Koch   +12 more
doaj   +1 more source

Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways

Frontiers in Pharmacology, 2020
Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively regulates the growth and development of muscle cells. Recent research has shown that myostatin might play an essential role in bone metabolism.
Xin Zhi, Qian Chen, Shaojun Song, Zhengrong Gu, Wenqiang Wei, Huiwen Chen, Xiao Chen, Weizong Weng, Qirong Zhou, Jin Cui, Liehu Cao   +10 more
doaj   +1 more source

The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy. [PDF]

PLoS ONE, 2015
Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating ...
Yutaka Ohsawa, Kentaro Takayama, Shin-ichiro Nishimatsu, Tadashi Okada, Masahiro Fujino, Yuta Fukai, Tatsufumi Murakami, Hiroki Hagiwara, Fumiko Itoh, Kunihiro Tsuchida, Yoshio Hayashi, Yoshihide Sunada   +11 more
doaj   +1 more source

Myostatin: Basic biology to clinical application

, 2022
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed by animal and human skeletal muscle cells where it limits muscle growth and promotes protein breakdown.
Costigliolo F., Esposito P., Viazzi F., Battaglia Y., Picciotto D., Verzola D., Picciotto, Daniela, Yuri Battaglia, Francesca Viazzi, Costigliolo, Francesca, BATTAGLIA, YURI, Viazzi, Francesca, Verzola, Daniela, Esposito, Pasquale, Daniela Verzola, Daniela Picciotto, Francesca Costigliolo, Pasquale Esposito   +17 more
core   +2 more sources

Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients

Critical Care, 2022
Background The objective was to investigate the role of gene expression and plasma levels of the muscular protein myostatin in intensive care unit-acquired weakness (ICUAW).
Julius J. Grunow, Katja Reiher, Niklas M. Carbon, Lilian Jo Engelhardt, Knut Mai, Susanne Koch, Joerg C. Schefold, Werner Z’Graggen, Stefan J. Schaller, Jens Fielitz, Joachim Spranger, Steffen Weber-Carstens, Tobias Wollersheim   +12 more
doaj   +1 more source

Deciphering Myostatin’s Regulatory, Metabolic, and Developmental Influence in Skeletal Diseases

Frontiers in Genetics, 2021
Current research findings in humans and other mammalian and non-mammalian species support the potent regulatory role of myostatin in the morphology and function of muscle as well as cellular differentiation and metabolism, with real-life implications in ...
Catherine L. Omosule, Charlotte L. Phillips, Charlotte L. Phillips   +2 more
doaj   +1 more source

Bazi Bushen Attenuates Skeletal Muscle Decline Associated With Oestrogen Deficiency and Modulates FGFR1/ERK Signalling. [PDF]

J Cell Mol Med
ABSTRACT Postmenopausal oestrogen deficiency is associated with skeletal muscle loss and functional decline, thereby increasing the risk of sarcopenia in women. Considering the safety risks linked to hormone replacement therapy (HRT), alternative strategies are needed to attenuate skeletal muscle decline after menopause.
Huang D, Xu N, Chu Q, Jia Z, Wang Y, Xu J.   +5 more
europepmc   +2 more sources

Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p

Frontiers in Immunology, 2017
Rheumatoid arthritis (RA) is characterized by the infiltration of a number of pro-inflammatory cytokines into synovial fluid and patients with RA often develop joint destruction and deficits in muscle mass.
Sung-Lin Hu, Sung-Lin Hu, An-Chen Chang, Chien-Chung Huang, Chien-Chung Huang, Chun-Hao Tsai, Chun-Hao Tsai, Cheng-Chieh Lin, Cheng-Chieh Lin, Cheng-Chieh Lin, Chih-Hsin Tang, Chih-Hsin Tang, Chih-Hsin Tang   +12 more
doaj   +1 more source