Results 41 to 50 of about 19,108 (217)
Quadriceps myostatin expression in COPD [PDF]
European Respiratory Journal, 2010 To the Editors: Quadriceps muscle dysfunction is well recognised in chronic obstructive pulmonary disease (COPD), and is associated with impaired exercise capacity and increased mortality 1. Functionally, the quadriceps is characterised by reduced strength, increased fatigability and decreased endurance, associated with muscle fibre atrophy and a ...
W D-C, Man +6 more
openaire +2 more sources
Association between serum GDF-15, myostatin, and sarcopenia in cardiovascular surgery patients
International Journal of Cardiology: Heart & Vasculature, 2022 Background: Myostatin is a negative regulator of skeletal muscle mass. On the other hand, growth differentiation factor (GDF)-15 is associated with lower muscle strength and muscle mass.
Riichi Nishikawa +13 more
doaj +1 more source
Myostatin in the Pathophysiology of Skeletal Muscle [PDF]
Current Genomics, 2007 Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells ...
Carnac, Gilles +2 more
openaire +2 more sources
Cord blood myostatin concentrations by gestational diabetes mellitus and fetal sex
Frontiers in Endocrinology, 2023 IntroductionMyostatin is a member of the transforming growth factor β superfamily, and is mainly secreted from skeletal muscle. Animal studies have demonstrated that deficiency in myostatin promotes muscle growth and protects against insulin resistance ...
Rong Huang +14 more
doaj +1 more source
Inhibition of myostatin signaling through Notch activation following acute resistance exercise. [PDF]
PLoS ONE, 2013 Myostatin is a TGFβ family member and negative regulator of muscle size. Due to the complexity of the molecular pathway between myostatin mRNA/protein and changes in transcription, it has been difficult to understand whether myostatin plays a role in ...
Matthew G MacKenzie +4 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale +6 more
wiley +1 more source
The role of myostatin during postnatal myogenesis and sarcopenia [PDF]
, 2007 Myostatin, a TGF-β superfamily member, is a key negative regulator of embryonic and postnatal muscle growth. In order to further elucidate the role of myostatin during postnatal growth, several lines of investigation were undertaken in mice.
Siriett, Victoria Katherine
core
3152 The role of myostatin in diabetic bone disease
Journal of Clinical and Translational Science, 2019 OBJECTIVES/SPECIFIC AIMS: Our primary objective is to determine the mechanism of action of myostatin on osteoblasts by measuring markers of osteoblast differentiation.
Evangelia Kalaitzoglou +2 more
doaj +1 more source
Advanced Science, EarlyView.Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi +11 more
wiley +1 more source
Plasma and muscle myostatin in relation to type 2 diabetes.
PLoS ONE, 2012 ObjectiveMyostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance.
Claus Brandt +5 more
doaj +1 more source