Results 51 to 60 of about 12,955 (195)

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Hypercortisolism: An Under‐Recognised Pathway Linked to Multi‐System Complications

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT The clinical understanding of hypercortisolism (HC) has evolved from a classic overt syndrome with florid Cushingoid features to a broader spectrum of disease that includes milder presentations, often referred to as mild autonomous cortisol secretion (MACS).
Hernan Daniel Sacoto, Vivian A. Fonseca
wiley   +1 more source

Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Myostatin is a negative regulator of muscle growth but the relationship between serum myostatin levels and muscle mass is unclear. This study investigated the association between serum myostatin levels and skeletal muscle mass among healthy ...
Li‐Ning Peng, Wei‐Ju Lee, Li‐Kuo Liu, Ming‐Hsien Lin, Liang‐Kung Chen   +4 more
doaj   +1 more source

Discovery of a mammalian splice variant of myostatin that stimulates myogenesis. [PDF]

PLoS ONE, 2013
Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals.
Ferenc Jeanplong, Shelley J Falconer, Jenny M Oldham, Mark Thomas, Tarra S Gray, Alex Hennebry, Kenneth G Matthews, Frederick C Kemp, Ketan Patel, Carole Berry, Gina Nicholas, Christopher D McMahon   +11 more
doaj   +1 more source

Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults—A Narrative Review

Orthopaedic Surgery, EarlyView.
This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu, Fan Xu, Maoqiang Fan, Yao Liu, Zhe Song   +4 more
wiley   +1 more source

Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy

BMC Medical Genomics, 2011
Background Myostatin is a potent muscle growth inhibitor that belongs to the Transforming Growth Factor-β (TGF-β) family. Mutations leading to non functional myostatin have been associated with hypermuscularity in several organisms. By contrast, Duchenne
van Ommen Gert Jan B, den Dunnen Johan T, de Gorter David JJ, Terlouw Samuel, van Heiningen Sandra H, Hoogaars Willem MH, Kemaladewi Dwi U, Aartsma-Rus Annemieke, ten Dijke Peter, 't Hoen Peter AC   +9 more
doaj   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

A myostatin-CCL20–CCR6 axis regulates Th17 cell recruitment to inflamed joints in experimental arthritis

Scientific Reports, 2021
The interactions of fibroblast-like synoviocyte (FLS)-derived pro-inflammatory cytokines/chemokines and immune cells support the recruitment and activation of inflammatory cells in RA. Here, we show for the first time that the classical myokine myostatin
Michelle Fennen, Toni Weinhage, Vanessa Kracke, Johanna Intemann, Georg Varga, Corinna Wehmeyer, Dirk Foell, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar   +9 more
doaj   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study

Annals of Clinical and Translational Neurology
Objective This study investigated myostatin levels in SMA patients receiving disease‐modifying therapies (DMTs) to understand their relationship with treatment duration and functional status.
Fiorella Piemonte, Sara Petrillo, Anna Capasso, Giorgia Coratti, Adele D'Amico, Michela Catteruccia, Maria Carmela Pera, Concetta Palermo, Marika Pane, Emanuela Abiusi, Gianpaolo Cicala, Marianna Villa, Chiara Bravetti, Chiara Arpaia, Agnese Novelli, Salvatore Falqui, Stefania Fiori, Giulia Napoli, Silvia Baroni, Francesco Danilo Tiziano, Enrico Bertini, Giacomo Comi, Stefania Corti, Eugenio Mercuri   +23 more
doaj   +1 more source