Results 31 to 40 of about 19,108 (217)
Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways. [PDF]
PLoS ONE, 2007 Myostatin is a transforming growth factor-beta family member that normally acts to limit skeletal muscle growth. Mice genetically engineered to lack myostatin activity have about twice the amount of muscle mass throughout the body, and similar effects ...
Se-Jin Lee
doaj +1 more source
Myostatin levels in skeletal muscle of hibernating ground squirrels [PDF]
, 2011 Myostatin, a negative regulator of muscle mass, is elevated during disuse and starvation. Mammalian hibernation presents a unique scenario, where animals are hypocaloric and in torpor, but the extent of muscle protein loss is minimized.
Brooks, Naomi +5 more
core +1 more source
Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
BMC Research Notes, 2010 Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with
Cheng Ye +2 more
doaj +1 more source
npj Microgravity, 2023 Novel treatments for muscle wasting are of significant value to patients with disease states that result in muscle weakness, injury recovery after immobilization and bed rest, and for astronauts participating in long-duration spaceflight.
Andrea M. Hanson +6 more
doaj +1 more source
Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide [PDF]
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2016 Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth, and its activity is suppressed by MSTN propeptide (MSTNpro), the N-terminal part of MSTN precursor cleaved during post-translational MSTN processing. The current study examined which region of flatfish (Paralichthys olivaceus) MSTN-1 propeptide (MSTN1pro) is critical for MSTN ...
Sang Beum, Lee +4 more
openaire +2 more sources
The role of acute ambient hypoxia in the regulation of myostatin [PDF]
, 2015 When exposed to chronic hypoxia by pathophysiological or environmental causes humans show muscle atrophy, challenging homeostasis and increasing mortality rate. Chronic hypoxia also presents with elevated myostatin peptide, a negative regulator of muscle
Elliott, B.
core +1 more source
Aging, 2014 The aging of a multicellular organism is an intricate process that results from signaling events and age-related degeneration in cells, tissues, and organ systems. Studies in model organisms have provided evidence of unanticipated connection between local and systemic aging [1]. Research in this field is defining the key tissues that govern an organism'
Vishal K, Patel, Fabio, Demontis
openaire +2 more sources
Serum myostatin levels are associated with abdominal aortic calcification in dialysis patients
Kidney Research and Clinical Practice, 2019 Background : Serum myostatin levels are increased according to renal function decline and myostatin may be a main mediator of chronic kidney disease–related sarcopenia.
Su Mi Lee +5 more
doaj +1 more source
The central role of myostatin in skeletal muscle and whole body homeostasis [PDF]
, 2012 Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It plays a key role in skeletal muscle homeostasis and has now been well described since its discovery.
Mackenzie, R.W.A. +9 more
core +1 more source
Myostatin-Induced Muscle Hypertrophy: A Comprehensive Review
, 2023 Myostatin, a protein in the TGF-β superfamily, strongly inhibits muscle growth. Inhibition of myostatin can cause muscle hypertrophy, and overexpression can cause muscle atrophy, a rare condition found in humans, cattle, and sheep.
gurusha bahl (17295139) +2 more
core +1 more source