Results 1 to 10 of about 4,991 (262)

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors [PDF]

Biomolecules, 2020
Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway.
Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien   +5 more
doaj   +2 more sources

In vitro and in silico insights on the regulation by gonadal hormones of pituitary GnRH receptor expression in a basal teleost, the European eel [PDF]

Frontiers in Endocrinology
Eel species are basal teleosts with a unique life cycle including an arrest of sexual maturation before the reproductive oceanic migration. Our early studies showed that this blockade results from a deficient production of pituitary gonadotropins, due in
Chien-Ju Lin, Chien-Ju Lin, Karine Rousseau, Ching-Fong Chang, Sylvie Dufour, Sylvie Dufour   +5 more
doaj   +2 more sources

Activins and Inhibins in Cardiovascular Pathophysiology [PDF]

Biomolecules
Activins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone.
Wenyi Tang, Zhilin Gu, Jiuqi Guo, Mingzhi Lin, Hongqian Tao, Dalin Jia, Pengyu Jia   +6 more
doaj   +2 more sources

Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance

Frontiers in Immunology, 2022
The TGF-β superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related to cell signaling, growth, development, and differentiation. Although its central member, TGF-β,
Nahum Puebla, James Welsh, Maria Angelica Cortez   +2 more
exaly   +3 more sources

Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy [PDF]

OncoImmunology
Activins, members of the TGF-beta superfamily, have been isolated and identified in the endocrine system, but have not been substantially investigated in the context of the immune system and endocrine-unrelated cancers.
Ying Zheng, Andriana Lebid, Liam Chung, Juan Fu, Xiaoxu Wang, Andrea Otrocol, Jelani C. Zarif, Hong Yu, Nicolas J. Llosa, Drew M. Pardoll   +9 more
doaj   +2 more sources

TGF-β Signaling in the Pathophysiology of the Ovary: A Double-Edged Regulator [PDF]

Biomolecules
The Transforming Growth Factor-β (TGF-β) superfamily comprises highly conserved cytokines that orchestrate key cellular functions, including proliferation, differentiation, and apoptosis. Within the ovary, TGF-β family members serve as pivotal regulators
Nicole Bertani, Alessandra Alteri, Luciana Cacciottola, Giorgia D’Addato, Gina La Sala, Biliana Lozanoska-Ochser, Micol Massimiani, Edoardo Parrella, Alessio Reggio, Eleonora Russo, Federica Campolo, Francesca Gioia Klinger   +11 more
doaj   +2 more sources

Activin Actions in Adipocytes.

J Clin Endocrinol Metab
Abstract Obesity is a growing global health problem characterized by excess fat accumulation. Though causes of obesity are multifactorial, glucagon-like peptide 1 receptor agonists have emerged as effective weight loss drugs. Nevertheless, these agents are expensive, not uniformly available, and must be used continuously.
Ongaro L, Bernard DJ.
europepmc   +3 more sources

Treatment Paradigm Shifts in Pulmonary Arterial Hypertension [PDF]

JACC: Asia
Wen Wen, MD, Yunshan Cao, MD, PhD
doaj   +2 more sources

Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments

Cells, 2021
Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting ...
Juha J. Hulmi, Tuuli A. Nissinen, Fabio Penna, Andrea Bonetto   +3 more
doaj   +1 more source

Activins and activin antagonists in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2008
In many parts of the world hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood. There is increasing evidence that activins, which are members of the transforming growth factor beta (TGFbeta) superfamily of growth and differentiation factors ...
Alev, Deli, Emanuel, Kreidl, Stefan, Santifaller, Barbara, Trotter, Katja, Seir, Walter, Berger, Rolf, Schulte-Hermann, Chantal, Rodgarkia-Dara, Michael, Grusch   +8 more
openaire   +2 more sources