Results 1 to 10 of about 4,459 (113)
In vitro and in silico insights on the regulation by gonadal hormones of pituitary GnRH receptor expression in a basal teleost, the European eel [PDF]
Frontiers in EndocrinologyEel species are basal teleosts with a unique life cycle including an arrest of sexual maturation before the reproductive oceanic migration. Our early studies showed that this blockade results from a deficient production of pituitary gonadotropins, due in
Chien-Ju Lin +5 more
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Frontiers in Immunology, 2022 The TGF-β superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related to cell signaling, growth, development, and differentiation. Although its central member, TGF-β,
Nahum Puebla-Osorio +2 more
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Activins and Inhibins in Cardiovascular Pathophysiology [PDF]
BiomoleculesActivins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone.
Wenyi Tang +6 more
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Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy [PDF]
OncoImmunologyActivins, members of the TGF-beta superfamily, have been isolated and identified in the endocrine system, but have not been substantially investigated in the context of the immune system and endocrine-unrelated cancers.
Ying Zheng +9 more
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Molecular Characterization of Recombinant Human Inhibin α- and βB-Subunits and Activin A (βA-βA) Using Raman Spectroscopy [PDF]
Current Issues in Molecular BiologyMembers of the transforming growth factor-β (TGF-β) superfamily, including inhibins and activins, are structurally related signaling proteins that regulate reproductive and endocrine physiology.
Weiyu Xiao +4 more
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TGF-β Signaling in the Pathophysiology of the Ovary: A Double-Edged Regulator [PDF]
BiomoleculesThe Transforming Growth Factor-β (TGF-β) superfamily comprises highly conserved cytokines that orchestrate key cellular functions, including proliferation, differentiation, and apoptosis. Within the ovary, TGF-β family members serve as pivotal regulators
Nicole Bertani +11 more
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Treatment Paradigm Shifts in Pulmonary Arterial Hypertension [PDF]
JACC: AsiaWen Wen, MD, Yunshan Cao, MD, PhD
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Cells, 2021 Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting ...
Juha J. Hulmi +3 more
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Biomolecules, 2020 Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway.
Oddrun Elise Olsen +5 more
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TAK1 inhibition increases proliferation and differentiation of chick retinal cells
Frontiers in Cell and Developmental Biology, 2022 The factors necessary for the differentiation of cell types within the retina are incompletely understood. The transforming growth factor beta (TGF-β) superfamily, including TGF-β1 and 2, the bone morphogenetic proteins, and the activins have all been ...
Casandra Carrillo +4 more
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