Results 11 to 20 of about 5,391 (252)

Activins in adipogenesis and obesity [PDF]

International Journal of Obesity, 2012
International audienceActivins are secreted proteins members of the transforming growth factor-β family. They are involved in many biological responses including regulation of apoptosis, proliferation and differentiation of different cell types. Activins
Dani, C., C Dani
core   +4 more sources

Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan [PDF]

International Journal of Inflammation, 2014
Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin ...
Jun Yamada, Kunikazu Tsuji, Kazumasa Miyatake, Yu Matsukura, Kahaer Abula, Makiko Inoue, Ichiro Sekiya, Takeshi Muneta   +7 more
doaj   +2 more sources

Activins and Follistatin in Chronic Hepatitis C and Its Treatment with Pegylated-Interferon-α Based Therapy [PDF]

Mediators of Inflammation, 2015
Pegylated-interferon-α based therapy for the treatment of chronic hepatitis C (CHC) is considered suboptimal as not all patients respond to the treatment and it is associated with several side effects that could lead to dose reduction and/or termination ...
Bassem Refaat, Ahmed Mohamed Ashshi, Adel Galal El-Shemi, Esam Azhar   +3 more
doaj   +2 more sources

Drosophila activins adapt gut size to food intake and promote regenerative growth

Nature Communications
Rapidly renewable tissues adapt different strategies to cope with environmental insults. While tissue repair is associated with increased intestinal stem cell (ISC) proliferation and accelerated tissue turnover rates, reduced calorie intake triggers a ...
Christian F. Christensen, Quentin Laurichesse, Rihab Loudhaief, Julien Colombani, Ditte S. Andersen   +4 more
doaj   +2 more sources

Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes: A Preliminary Report [PDF]

Gastroenterology Research and Practice, 2014
Aims. To measure the effect of pegylated interferon-α therapy on serum activin-A, activin-B, and follistatin and their correlation with viral load and liver fibrosis in chronic hepatitis C (CHC). Methods.
Bassem Refaat, Adel Galal El-Shemi, Ahmed Mohamed Ashshi, Adnan AlZanbagi   +3 more
doaj   +2 more sources

Activins and activin antagonists in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2008
In many parts of the world hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood. There is increasing evidence that activins, which are members of the transforming growth factor beta (TGFbeta) superfamily of growth and differentiation factors ...
Alev, Deli, Emanuel, Kreidl, Stefan, Santifaller, Barbara, Trotter, Katja, Seir, Walter, Berger, Rolf, Schulte-Hermann, Chantal, Rodgarkia-Dara, Michael, Grusch   +8 more
openaire   +2 more sources

Antagonism of Activin by Activin Chimeras [PDF]

, 2011
Activins are pluripotent hormones/growth factors that belong to the TGF-β superfamily of growth and differentiation factors (GDFs). They play a role in cell growth, differentiation and apoptosis, endocrine function, metabolism, wound repair, immune responses, homeostasis, mesoderm induction, bone growth, and many other biological processes.
Uwe, Muenster, Radhika, Korupolu, Ratindra, Rastogi, Jessica, Read, Wolfgang H, Fischer   +4 more
openaire   +2 more sources

Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]

Endocrinology, 2011
Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Makanji, Yogeshwar, Walton, Kelly L., Chan, Karen L., Gregorevic, Paul, Robertson, David M., Harrison, Craig A.   +5 more
openaire   +4 more sources

A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling

Cellular & Molecular Biology Letters, 2023
Background TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily, blocks TGFβ1 profibrotic effects, but the ...
Asfia Soomro, Mohammad Khajehei, Renzhong Li, Kian O’Neil, Dan Zhang, Bo Gao, Melissa MacDonald, Masao Kakoki, Joan C. Krepinsky   +8 more
doaj   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source