Results 41 to 50 of about 5,391 (252)

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Differential expression of follistatin and FLRG in human breast proliferative disorders

BMC Cancer, 2009
Background Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines.
Amaral Vania F, Grasso Giovanni, Muscettola Michela, Borges Lavinia E, Mencarelli Marzia, Ciarmela Pasquapina, Massai Lauretta, Couto Henrique L, Bloise Enrrico, Cassali Geovanni D, Petraglia Felice, Reis Fernando M   +11 more
doaj   +1 more source

Immunolocalization of activin and inhibin at different stages of follicular development in the lizard Sceloporus torquatus

Heliyon, 2023
The activins and inhibins are glycoproteins with a role in the follicular development of vertebrates, that are found in follicular fluid and somatic follicular cells, with a different pattern among taxa.
N.B. Cruz-Cano, U.Á. Sánchez-Rivera, C. Álvarez-Rodríguez, R.E. Loya-Zurita, Y.J. Castro-Camacho, M. Martínez-Torres   +5 more
doaj   +1 more source

Phase 3, Open-Label Multicenter Study of Sotatercept in Japanese Participants With Pulmonary Arterial Hypertension

JACC: Asia
Background: Sotatercept is a first-in-class activin signaling inhibitor, developed for the treatment of pulmonary arterial hypertension (PAH). Objectives: This open-label single-arm, multicenter, phase 3 study was initiated to evaluate the efficacy and ...
Hiromi Matsubara, MD, PhD, Nobuhiro Tanabe, MD, PhD, Takeshi Ogo, MD, PhD, Kohtaro Abe, MD, PhD, Takumi Inami, MD, PhD, Yuko Maeda, PhD, Ichiro Arano, PhD, Masayoshi Shirakawa, MSc, Ryosuke Sakai, MSc, Alexandra G. Cornell, MD, MCR, Ichizo Tsujino, Nobuhiro Yaoita, Toshihiko Sugiura, Nobuhiro Tanabe, Takumi Inami, Masaru Hatano, Takahiro Hiraide, Yuichi Tamura, Shiro Adachi, Takeshi Ogo, Yu Taniguchi, Hiromi Matsubara, Nobuhiro Tahara, Kohtaro Abe, Hiroshi Watanabe, Yoshihiro Dohi, Akiyoshi Hashimoto   +26 more
doaj   +1 more source

Effect of Activin A on In Vitro Development of Rat Preantral Follicles and Localization of Activin A and Activin Receptor II [PDF]

Biology of Reproduction, 2001
Preantral follicles (140-160 microm) were isolated mechanically from the ovaries of 10-day-old rats and cultured in groups of four to six for 6 days in medium containing 0, 1, 10, or 100 ng/ml of activin A. Activin stimulated (P < 0.05) the growth of preantral follicles in a dose-dependent fashion and enhanced the proliferation of preantral, oocyte ...
Yu-Zhao, J., Taverne, M.A.M., van der Weijden, G.C., Bevers, M.M., van den Hurk, R.   +4 more
openaire   +3 more sources

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Activins Family

, 2019
Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release.
nancy murray (6884852)
core   +1 more source

Defined Matrices Reveal Epithelial‐ and Mesenchymal‐Specific Responses to Stiffness and Adhesion in Human iPSC‐Derived Intestinal Organoids

Advanced Materials, EarlyView.
Defined PEG hydrogels enable human iPSC‐derived intestinal organoid culture without Matrigel. PEG‐ and Matrigel‐cultured organoids both support duodenal‐like epithelial identity, but direct comparison reveals subtle epithelial differentiation‐marker shifts and stronger mesenchymal ECM‐remodeling/integrin programs in PEG.
Alicja Kuziola, Tamara Fawzi, Emma H. Kromann, Marion Leleu, Joanna M. Drelinkiewicz, Dusko Ilic, Cécile A. Dreiss, Joana F. Neves, Eileen Gentleman   +8 more
wiley   +1 more source

Prognostic value of activin A level in patients with advanced lung cancer and sarcopenia

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The aim of this work is to determine the prognostic role of activin A in patients with advanced lung cancer and sarcopenia. Materials and methods.
V. V. Kechedzhyiev
doaj   +1 more source

Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B.

PLoS ONE, 2020
Activins are members of the transforming growth factor-β (TGF-β) superfamily of signaling proteins and were originally identified as components of follicular fluid.
Paul C Billings, Candice Bizzaro, Evan Yang, Juliet Chung, Christina Mundy, Maurizio Pacifici   +5 more
doaj   +1 more source