Results 51 to 60 of about 4,991 (262)

Immunolocalization of activin and inhibin at different stages of follicular development in the lizard Sceloporus torquatus

Heliyon, 2023
The activins and inhibins are glycoproteins with a role in the follicular development of vertebrates, that are found in follicular fluid and somatic follicular cells, with a different pattern among taxa.
N.B. Cruz-Cano, U.Á. Sánchez-Rivera, C. Álvarez-Rodríguez, R.E. Loya-Zurita, Y.J. Castro-Camacho, M. Martínez-Torres   +5 more
doaj   +1 more source

The role of activins and follistatins in skin and hair follicle development and function [PDF]

, 2008
Investigations of the signalling between epithelial and mesenchymal compartments of skin during hair follicle initiation in utero and hair cycling have revealed the importance of the TGFbeta superfamily in ectodermal organogenesis and morphogenesis.
M. McDowall, P.I. Hynd, Edwards, N., N.M. Edwards, McDowall, M., Hynd, P., Jahoda, C., C.A.B. Jahoda   +7 more
core   +1 more source

Prognostic value of activin A level in patients with advanced lung cancer and sarcopenia

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The aim of this work is to determine the prognostic role of activin A in patients with advanced lung cancer and sarcopenia. Materials and methods.
V. V. Kechedzhyiev
doaj   +1 more source

Effect of Activin A on In Vitro Development of Rat Preantral Follicles and Localization of Activin A and Activin Receptor II [PDF]

Biology of Reproduction, 2001
Preantral follicles (140-160 microm) were isolated mechanically from the ovaries of 10-day-old rats and cultured in groups of four to six for 6 days in medium containing 0, 1, 10, or 100 ng/ml of activin A. Activin stimulated (P < 0.05) the growth of preantral follicles in a dose-dependent fashion and enhanced the proliferation of preantral, oocyte ...
Yu-Zhao, J., Taverne, M.A.M., van der Weijden, G.C., Bevers, M.M., van den Hurk, R.   +4 more
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Phase 3, Open-Label Multicenter Study of Sotatercept in Japanese Participants With Pulmonary Arterial Hypertension

JACC: Asia
Background: Sotatercept is a first-in-class activin signaling inhibitor, developed for the treatment of pulmonary arterial hypertension (PAH). Objectives: This open-label single-arm, multicenter, phase 3 study was initiated to evaluate the efficacy and ...
Hiromi Matsubara, MD, PhD, Nobuhiro Tanabe, MD, PhD, Takeshi Ogo, MD, PhD, Kohtaro Abe, MD, PhD, Takumi Inami, MD, PhD, Yuko Maeda, PhD, Ichiro Arano, PhD, Masayoshi Shirakawa, MSc, Ryosuke Sakai, MSc, Alexandra G. Cornell, MD, MCR, Ichizo Tsujino, Nobuhiro Yaoita, Toshihiko Sugiura, Nobuhiro Tanabe, Takumi Inami, Masaru Hatano, Takahiro Hiraide, Yuichi Tamura, Shiro Adachi, Takeshi Ogo, Yu Taniguchi, Hiromi Matsubara, Nobuhiro Tahara, Kohtaro Abe, Hiroshi Watanabe, Yoshihiro Dohi, Akiyoshi Hashimoto   +26 more
doaj   +1 more source

Vascularization of Human iPSC‐Derived Kidney Organoids Using Perfusion Culture, Pre‐Vascularized Collagen Scaffolds, and Decellularized Extracellular Matrix

Advanced Healthcare Materials, EarlyView.
An integrated perfusion‐based culture platform combining pre‐vascularized collagen scaffolds, stromal vascular fraction cells, and kidney decellularized extracellular matrix promotes vascularization of human iPSC‐derived kidney organoids. The platform provides evidence of interactions between vascular networks and glomerular‐like structures and enables
Helen Kearney, Andrea Mazzoleni, Ivan Martin, Lorenzo Moroni, Manuele Giuseppe Muraro, Carlos Mota   +5 more
wiley   +1 more source

Sex-specific regulation of prolactin secretion by pituitary activins in postnatal development [PDF]

, 2023
Serum prolactin increases from birth to adulthood in rats, being higher in females from birth. The maturation of hypothalamic/gonadal prolactin-releasing and -inhibiting factors does not explain some sex differences observed.
Diaz, Graciela Susana, Dana Bornancini, Peña Zanoni, Milagros, Milagros Peña-Zanoni, Abeledo Machado, Alejandra Inés, Graciela Díaz-Torga, Bornancini, Dana, Faraoni, Erika Yanil, Alejandra Abeledo-Machado, Camilletti, María Andrea, Erika Yanil Faraoni, María Andrea Camilletti   +11 more
core   +1 more source

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo–orchitis in mice

Scientific Reports, 2017
Experimental autoimmune epididymo-orchitis (EAEO) is a model of chronic inflammation, induced by immunisation with testicular antigens, which reproduces the pathology of some types of human infertility.
Nour Nicolas, Vera Michel, Sudhanshu Bhushan, Eva Wahle, Susan Hayward, Helen Ludlow, David M. de Kretser, Kate L. Loveland, Hans-Christian Schuppe, Andreas Meinhardt, Mark P. Hedger, Monika Fijak   +11 more
doaj   +1 more source

Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B.

PLoS ONE, 2020
Activins are members of the transforming growth factor-β (TGF-β) superfamily of signaling proteins and were originally identified as components of follicular fluid.
Paul C Billings, Candice Bizzaro, Evan Yang, Juliet Chung, Christina Mundy, Maurizio Pacifici   +5 more
doaj   +1 more source