Results 61 to 70 of about 4,991 (262)
Cripto forms a complex with activin and type II activin receptors and can block activin signaling [PDF]
Proceedings of the National Academy of Sciences, 2003 Activin, nodal, Vg1, and growth and differentiation factor 1 are members of the transforming growth factor β superfamily and signal via the activin type II (ActRII/IIB) and type I (ALK4) serine/threonine kinase receptors. Unlike activins, however, signaling by nodal, Vg1, and growth and differentiation factor 1 requires a coreceptor from the epidermal ...
Peter C, Gray +2 more
openaire +2 more sources
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
The role of activins in hepcidin regulation during malaria [PDF]
, 2017 Epidemiological observations have linked increased host iron with malaria susceptibility, and perturbed iron handling has been hypothesized to contribute to the potentially life threatening anemia that may accompany blood-stage malaria infection.
Armitage, AE +14 more
core +6 more sources
Advanced Science, EarlyView.Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang +8 more
wiley +1 more source
Journal of Translational Medicine, 2018 Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment. Methods This study introduces the weighted standing
Alice M. Richardson +7 more
doaj +1 more source
Activin B is produced early in antral follicular development and suppresses thecal androgen production [PDF]
, 2012 Little is known about the role of activin B during folliculogenesis. This study investigated the expression levels of activin/inhibin subunits (βA, βB, and α), steroid enzyme, and gonadotrophin receptors in theca (TC) and granulosa cells (GC) by QPCR and
Young, J M +5 more
core +1 more source
Regulation of fetal male germ cell development by members of the TGFβ superfamily
Stem Cell Research, 2017 There is now substantial evidence that members of the transforming growth factor-β (TGFβ family) regulate germ cell development in the mouse fetal testis.
Cassy Spiller +2 more
doaj +1 more source
TGF-β signaling in lymphatic vascular vessel formation and maintenance
Frontiers in Physiology, 2022 Transforming growth factor (TGF)-β and its family members, including bone morphogenetic proteins (BMPs), nodal proteins, and activins, are implicated in the development and maintenance of various organs. Here, we review its role in the lymphatic vascular
Fumiko Itoh, Tetsuro Watabe
doaj +1 more source
Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis
Advanced Science, EarlyView.A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa +5 more
wiley +1 more source
The role of activins during decidualisation of human endometrium [PDF]
, 2006 Decidualisation of the endometrial stroma is critical to create a specialised environment for embryo implantation and trophoblast invasion; however, the mechanisms involved are poorly understood.
Jock K. FINDLAY +5 more
core +1 more source