Results 61 to 70 of about 5,391 (252)

Designer TGFβ superfamily ligands with diversified functionality. [PDF]

PLoS ONE, 2011
Transforming Growth Factor--beta (TGFβ) superfamily ligands, including Activins, Growth and Differentiation Factors (GDFs), and Bone Morphogenetic Proteins (BMPs), are excellent targets for protein-based therapeutics because of their pervasiveness in ...
George P Allendorph, Jessica D Read, Yasuhiko Kawakami, Jonathan A Kelber, Michael J Isaacs, Senyon Choe   +5 more
doaj   +1 more source

Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation

, 2015
SPSS file containing anonymised data set for the publication entitled: "Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation".
Robyn E O’Hehir (797208), Jonathan Bensley (797012), Enjarn Lin (797206), Bronwyn J Levvey (797204), Mark P Hedger (797207), Greg I Snell (797205), David M de Kretser (797202), David Philips (797203)   +7 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Toxicity of chemotherapy on skeletal muscles and the heart may significantly contribute to cancer cachexia, mortality, and decreased quality of life.
Juha J. Hulmi, Tuuli A. Nissinen, Markus Räsänen, Joni Degerman, Juulia H. Lautaoja, Karthik Amudhala Hemanthakumar, Janne T. Backman, Olli Ritvos, Mika Silvennoinen, Riikka Kivelä   +9 more
doaj   +1 more source

Activins as Regulators of Branching Morphogenesis

, 2001
Development of glandular organs such as the kidney, lung, and prostate involves the process of branching morphogenesis. The developing organ begins as an epithelial bud that invades the surrounding mesenchyme, projecting dividing epithelial cords or ...
Risbridger, Gail P., Ball, Emma M.A.
core   +1 more source

Activin B is produced early in antral follicular development and suppresses thecal androgen production [PDF]

, 2012
Little is known about the role of activin B during folliculogenesis. This study investigated the expression levels of activin/inhibin subunits (βA, βB, and α), steroid enzyme, and gonadotrophin receptors in theca (TC) and granulosa cells (GC) by QPCR and
Young, J M, McNeilly, A S, Henderson, S, Groome, N, Ludlow, H, Souza, C   +5 more
core   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Supplementary tables from: Serum activins, follistatins and growth factors in neoplasms of the breast: a case-control study

, 2018
Supplementary Tables for: Serum levels of activins, follistatins and growth factors in neoplasms of the breast: A case-control ...
Anastasios Vagionas (5613622), Eleni Papakonstantinou (5613620), Grigorios Panagiotou (5613167), Christos S. Mantzoros (452715), Stergios A. Polyzos (5613624)   +4 more
core   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Activins and activin receptors in the rat testis [PDF]

, 1994
Inhibin and activin are gonadal protein hormones, which were originally defined by their negative and positive feedback action on the release of follicle stimulating hormone (FSH) from the pituitary gland.
Winter, J.P. (Johan) de
core   +1 more source