Results 71 to 80 of about 5,391 (252)

Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish-A novel insight into its action mechanism.

PLoS Genetics, 2022
Growth differentiation factor 9 (GDF9) was the first oocyte-specific growth factor identified; however, most information about GDF9 functions comes from studies in the mouse model.
Weiting Chen, Yue Zhai, Bo Zhu, Kun Wu, Yuqin Fan, Xianqing Zhou, Lin Liu, Wei Ge   +7 more
doaj   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

Metabolic regulation of activins in healthy individuals and in obese patients undergoing bariatric surgery

, 2020
Objective: Follistatin binds and inactivates activins, which are potent inhibitors of muscle growth and metabolism and are currently being developed for the treatment of obesity and type 2 diabetes (T2D).
Peradze, N., Ghaly, W., Kokkinos, A., Tentolouris, N., Alexandrou, A., Mantzoros, C.S., Tsilingiris, D., Perakakis, N.   +7 more
core   +1 more source

Inactivating the Uninhibited: The Tale of Activins and Inhibins in Pulmonary Arterial Hypertension

, 2023
Advances in technology and biomedical knowledge have led to the effective diagnosis and treatment of an increasing number of rare diseases. Pulmonary arterial hypertension (PAH) is a rare disorder of the pulmonary vasculature that is associated with high
Gusty Rizky Teguh Ryanto, Noriaki Emoto, Tetsuya Hara, Ahmad Musthafa, Emoto, Noriaki, Musthafa, Ahmad, Ryanto, Gusty Rizky Teguh, Hara, Tetsuya   +7 more
core   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

Scientific Reports, 2022
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors.
Sachindra R. Joshi, Jun Liu, Troy Bloom, Elif Karaca Atabay, Tzu-Hsing Kuo, Michael Lee, Elitza Belcheva, Matthew Spaits, Rosa Grenha, Michelle C. Maguire, Jeffrey L. Frost, Kathryn Wang, Steven D. Briscoe, Mark J. Alexander, Brantley R. Herrin, Roselyne Castonguay, R. Scott Pearsall, Patrick Andre, Paul B. Yu, Ravindra Kumar, Gang Li   +20 more
doaj   +1 more source

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source

Evaluation of the potential roles of activin-A, activin-B, and follistatin molecules exhibiting immunomodulatory properties in brucellosis [PDF]

, 2021
Brucellosis is a zoonotic disease caused by bacteria called Brucella. The mechanisms underlying the changes seen in the course of brucellosis are not adequately elucidated.
Demir, Nesrin, Kızmaz, Muhammed Ali, Çağan, Eren, Ellergezen, Pinar Hiz, Oral, Haluk Barbaros, Budak, Ferah, Akalın, Emin Halis   +6 more
core   +1 more source

Activin B can signal through both ALK4 and ALK7 in gonadotrope cells

Reproductive Biology and Endocrinology, 2006
Background Activins stimulate pituitary FSH synthesis via transcriptional regulation of the FSHbeta subunit gene (Fshb). Like other members of the TGFbeta superfamily, these ligands signal through complexes of type I and type II receptor serine/threonine
Lee Katharine B, Bernard Daniel J, Santos Michelle M   +2 more
doaj   +1 more source

Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins

Molecular Metabolism, 2020
Objective: Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In preclinical animal models, blocking activin receptor (ACVR) ligands has improved survival and prevented muscle wasting in cancer cachexia without an ...
J.J. Hulmi, F. Penna, N. Pöllänen, T.A. Nissinen, J. Hentilä, L. Euro, J.H. Lautaoja, R. Ballarò, R. Soliymani, M. Baumann, O. Ritvos, E. Pirinen, M. Lalowski   +12 more
doaj   +1 more source