Results 1 to 10 of about 1,341 (116)
Journal of Cachexia, Sarcopenia and Muscle, 2019 Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Leonidas Koniaris +2 more
exaly +2 more sources
Activin B promotes the initiation and progression of liver fibrosis
Hepatology Communications, 2022 The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis.
Yan Wang +12 more
doaj +1 more source
Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells
Frontiers in Cellular Neuroscience, 2022 Activin A, a member of the TGF-β family, is recognized as a multifunctional protein in the adult brain with a particular impact on neuronal circuits associated with cognitive and affective functions.
Fang Zheng +3 more
doaj +1 more source
Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. [PDF]
PLoS ONE, 2015 Deregulated expression of activin A is reported in several tumors, but its biological functions in oral squamous cell carcinoma (OSCC) are unknown. Here, we investigate whether activin A can play a causal role in OSCCs.
Andreia Bufalino +14 more
doaj +1 more source
Activins and activin antagonists in hepatocellular carcinoma [PDF]
World Journal of Gastroenterology, 2008 In many parts of the world hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood. There is increasing evidence that activins, which are members of the transforming growth factor beta (TGFbeta) superfamily of growth and differentiation factors ...
Alev, Deli +8 more
openaire +2 more sources
Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury
Diagnostics, 2022 Activin is a multifunctional cytokine belonging to the transforming growth factor (TGF)-β superfamily that regulates the growth and differentiation of cells in various organs.
Izumi Nagayama +2 more
doaj +1 more source
Role of stromal activin A in human pancreatic cancer and metastasis in mice
Scientific Reports, 2021 Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in colon cancer and its stroma but its role in the stroma of PDAC has not been ...
Georgina Mancinelli +11 more
doaj +1 more source
The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes
Frontiers in Endocrinology, 2022 Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determinant ...
Sarah C. Moody +7 more
doaj +1 more source
Antagonism of Activin by Activin Chimeras [PDF]
, 2011 Activins are pluripotent hormones/growth factors that belong to the TGF-β superfamily of growth and differentiation factors (GDFs). They play a role in cell growth, differentiation and apoptosis, endocrine function, metabolism, wound repair, immune responses, homeostasis, mesoderm induction, bone growth, and many other biological processes.
Uwe, Muenster +4 more
openaire +2 more sources
Biomolecules, 2020 Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway.
Oddrun Elise Olsen +5 more
doaj +1 more source