Results 31 to 40 of about 12,305 (210)

Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Activin A is a protein that participates principally in reproductive functions. In the adult brain, Activin is neuroprotective, but its role in brain development is still elusive.
Griselda Rodríguez-Martínez, Anayansi Molina-Hernández, Iván Velasco   +2 more
doaj   +1 more source

Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids

Molecular Metabolism, 2023
Objective: The liver is a central regulator of energy metabolism exerting its influence both through intrinsic processing of substrates such as glucose and fatty acid as well as by secreting endocrine factors, known as hepatokines, which influence ...
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes, Emily A. Jordan, Alexis R. White, Stephen E. Flaherty, Barbara Bernardo, Trenton Ross, Kendra K. Bence, Morris J. Birnbaum   +10 more
doaj   +1 more source

Normal spermatogenesis in activin βA mutant males.

, 2022
(A) Morphology, gross anatomy, and histological structure of activin βA mutant males (inhbaa-/-, inhbab-/- and inhbaa-/-;inhbab-/-) at 120 dpf. (B) Activin βA single mutant males (inhbaa-/-, inhbab-/-) at 240 dpf.
Wei Ge (39218), Nana Ai (14216436), Weiyi Song (3441530), Cheng Zhao (2535307), Kun Wu (286745), Yue Zhai (3141960), Ruijing Geng (14216433)   +6 more
core   +1 more source

Activin-A Induces Fewer, but Larger Osteoclasts From Monocytes in Both Healthy Controls and Fibrodysplasia Ossificans Progressiva Patients

Frontiers in Endocrinology, 2020
Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease characterized by heterotopic ossification (HO) that occurs in muscle tissue, tendons, and ligaments.
Ton Schoenmaker, Esmée Botman, Merve Sariyildiz, Dimitra Micha, Coen Netelenbos, Nathalie Bravenboer, Angele Kelder, E. Marelise W. Eekhoff, Teun J. De Vries   +8 more
doaj   +1 more source

Effects of activin and TGFβ on p21 in colon cancer. [PDF]

, 2012
Activin and TGFβ share SMAD signaling and colon cancers can inactivate either pathway alone or simultaneously. The differential effects of activin and TGFβ signaling in colon cancer have not been previously dissected.
Cabral Jennifer, Barbara Jung, Judith C. Sporn (155661), Bauer Jessica, Jessica Gomez, Gomez Jessica, Jennifer Cabral (155669), Barbara Jung (155690), Jessica Bauer, Jennifer Cabral, Jung Barbara, Judith C Sporn, Jessica Bauer (155652), Jessica Gomez (155679), Sporn Judith C.   +14 more
core   +1 more source

Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models

Endocrine Journal
The hypothalamic-pituitary-gonadal (HPG) axis is primarily regulated by kisspeptin neurons. In addition, activin and inhibin within the central nervous system might contribute to the regulation of the HPG axis because they are expressed near kisspeptin ...
Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zhuoma Cairang, Batjargal Lkhagvajav, Aki Oride, Hiroe Okada, Satoru Kyo   +6 more
doaj   +1 more source

Expression of activin A.

, 2014
Activin A expression was determined using anti-activin A antibodies (goat polyclonal; 1∶50; R&D Systems; Minneapolis, MN, USA). A. Case 17; infected endophthalmitis.
Hidetoshi Yamashita (641923), Yoshiko Kashiwagi (641919), Hiroyuki Namba (641920), Mari Narumi (641918), Mitsunori Yamakawa (641922), Rintaro Ohe (641921)   +5 more
core   +1 more source

Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats

Frontiers in Bioscience-Landmark
Background: Rheumatic heart disease (RHD), which is caused mainly by Group A Streptococcus, leads to fibrotic damage to heart valves.
Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng   +6 more
doaj   +1 more source

Activin B antagonizes RhoA signaling to stimulate mesenchymal morphology and invasiveness of clear cell renal cell carcinomas. [PDF]

PLoS ONE, 2014
Activin B belongs to the TGFβ family of growth factors and is upregulated in clear cell renal cell carcinoma cells by hypoxia inducible factors. Expression of Activin B is required for tumor growth in vivo and tumor cell invasion in vitro.
Ingrid Wacker, Jürgen Behrens
doaj   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source