Results 11 to 20 of about 32,212 (230)

Activins and activin antagonists in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2008
In many parts of the world hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood. There is increasing evidence that activins, which are members of the transforming growth factor beta (TGFbeta) superfamily of growth and differentiation factors ...
Alev, Deli, Emanuel, Kreidl, Stefan, Santifaller, Barbara, Trotter, Katja, Seir, Walter, Berger, Rolf, Schulte-Hermann, Chantal, Rodgarkia-Dara, Michael, Grusch   +8 more
openaire   +2 more sources

Antagonism of Activin by Activin Chimeras [PDF]

, 2011
Activins are pluripotent hormones/growth factors that belong to the TGF-β superfamily of growth and differentiation factors (GDFs). They play a role in cell growth, differentiation and apoptosis, endocrine function, metabolism, wound repair, immune responses, homeostasis, mesoderm induction, bone growth, and many other biological processes.
Uwe, Muenster, Radhika, Korupolu, Ratindra, Rastogi, Jessica, Read, Wolfgang H, Fischer   +4 more
openaire   +2 more sources

Activin A directly impairs human cardiomyocyte contractile function indicating a potential role in heart failure development

Frontiers in Cardiovascular Medicine, 2022
Activin A has been linked to cardiac dysfunction in aging and disease, with elevated circulating levels found in patients with hypertension, atherosclerosis, and heart failure.
Scott MacDonnell, Jake Megna, Qin Ruan, Olivia Zhu, Gabor Halasz, Dan Jasewicz, Kristi Powers, Hock E, Maria del Pilar Molina-Portela, Ximei Jin, Dongqin Zhang, Justin Torello, Nicole T. Feric, Michael P. Graziano, Akshay Shekhar, Michael E. Dunn, David Glass, Lori Morton   +17 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer

Biomedicines, 2021
Activin, a member of the TGF-β superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer.
Wanglong Qiu, Chia-Yu Kuo, Yu Tian, Gloria H. Su   +3 more
doaj   +1 more source

Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis

Canadian Journal of Gastroenterology and Hepatology, 2022
Background. Cancer stem cells (CSCs) are involved in liver metastasis in colorectal cancer (CRC). Activin and hepatocyte growth factor (HGF) are important regulators of stem cell properties.
Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Zheng Jiang, Jinjun Guo   +5 more
doaj   +1 more source

Activins and Activin Receptors in Cell Growth

Experimental Biology and Medicine, 1997
Activin and inhibin, members of transforming growth factor-beta (TGFbeta) superfamily, have diverse and widespread effects within living organisms at many stages during growth and development. From the initial isolation of these growth factors based on their effects of FSH secretion, the study of these factors, as well as of the activin-binding protein
S Y, Ying, Z, Zhang, B, Furst, Y, Batres, G, Huang, G, Li   +5 more
openaire   +2 more sources

Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]

Endocrinology, 2011
Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Makanji, Yogeshwar, Walton, Kelly L., Chan, Karen L., Gregorevic, Paul, Robertson, David M., Harrison, Craig A.   +5 more
openaire   +4 more sources

Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector

Frontiers in Cellular and Infection Microbiology, 2019
Despite the increasing number of studies concerning insect immunity, Lutzomyia longipalpis immune responses in the presence of Leishmania infantum chagasi infection has not been widely investigated. The few available studies analyzed the role of the Toll
Tatiana Di-Blasi, Erich Loza Telleria, Erich Loza Telleria, Christiane Marques, Rodrigo de Macedo Couto, Monique da Silva-Neves, Magdalena Jancarova, Petr Volf, Antonio Jorge Tempone, Yara Maria Traub-Csekö   +9 more
doaj   +1 more source

Activin-A: active in inflammation in COPD [PDF]

European Respiratory Journal, 2014
Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow limitation in which chronic inflammation of the airways plays a major role. The persistent inflammation is triggered by inhaled toxic substances, such as cigarette smoke.
Tania, Navessa P., Schmidt, Martina, Gosens, Reinoud   +2 more
openaire   +2 more sources