Results 1 to 10 of about 59,475 (206)

The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

Journal of Cachexia, Sarcopenia and Muscle, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Xiaoling Zhong, Yanlin Jiang, George E Sandusky   +2 more
exaly   +2 more sources

Activin A is Not a Reliable Prognostic Biomarker For Bilirubin Induced Neurotoxicity in Neonates [PDF]

Pediatric Sciences Journal, 2022
Background: Bilirubin induced neurological dysfunction (BIND) remains an important cause of disability in developing countries. Although high total serum bilirubin (TSB) is the main instigator for BIND, different babies may have different neurological ...
Esraa A. El Mazzahy, Iman F. Iskander, Hazem H. Abouyoussef, Hanan A. Madani, Sarah S. El Tatawy   +4 more
doaj   +1 more source

Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]

, 2014
In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Arriola, David J, Park, Chung Hyun, Rivera, Alissa J, Skarra, Danalea V, Thackray, Varykina G   +4 more
core   +12 more sources

Improved Production of Recombinant Human Activin A in Escherichia coli [PDF]

Journal of Sciences, Islamic Republic of Iran, 2021
Activin A is a member of transforming growth factor β (TGF-β) superfamily. It plays numerous roles in the body such as cell growth regulation and differentiation, wound repairing and modulation of inflammatory responses.
Zahra Hajihassan, Navid Nazari, Fatemeh Armaghan   +2 more
doaj   +1 more source

ارزیابی تأثیر فاکتور رشد Activin A و کوچک مولکول‌ IDE1 در تکثیر و خودنوزایی سلول‌های زایای بدوی جوجه در شرایط کشت آزمایشگاهی [PDF]

زیست‌شناسی کاربردی, 2023
مقدمه: چالش‌ اصلی سلول‌ها سلول‌های زایای بدوی (PGC)، عدم تکثیر و خودنوزایی آن‌ها در محیط کشت است. یک روش برای القای پرتوانی سلول‌های PGC، دستکاری مسیرهای پیام‌رسانی درون‌سلولی ازجمله TGF-β است که استفاده از فاکتورهای رشد و کوچک مولکول‌ها یکی از روش‌های ...
معصومه زارع, سیدضیالدین میرحسینی, سیده نفیسه حسنی, شاهرخ قوتی   +3 more
doaj   +1 more source

Activin A regulates activation of mouse neutrophils by Smad3 signalling [PDF]

Open Biology, 2017
Activin A, a member of the transforming growth factor beta superfamily, acts as a pro-inflammatory factor in acute phase response, and influences the pathological progress of neutrophil-mediated disease.
Yan Qi, Jingyan Ge, Chunhui Ma, Na Wu, Xueling Cui, Zhonghui Liu   +5 more
doaj   +1 more source

Enhanced Expression of Recombinant Activin A in Escherichia coli by Optimization of Induction Parameters [PDF]

Journal of Sciences, Islamic Republic of Iran, 2018
Activin A is a member of the transforming growth factor β super family. Because of its extensive clinical usages, its recombinant production is beneficial. In this study, activin A was expressed in E. coli using the pET 21a expression vector.
Z. Hajihassan, N. Biroonro
doaj   +1 more source

Activins and activin antagonists in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2008
In many parts of the world hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood. There is increasing evidence that activins, which are members of the transforming growth factor beta (TGFbeta) superfamily of growth and differentiation factors ...
Alev, Deli, Emanuel, Kreidl, Stefan, Santifaller, Barbara, Trotter, Katja, Seir, Walter, Berger, Rolf, Schulte-Hermann, Chantal, Rodgarkia-Dara, Michael, Grusch   +8 more
openaire   +2 more sources

Serum levels of Activin A: Marker of insulin resistance and cardiovascular risk in prediabetics

Journal of Family Medicine and Primary Care, 2022
Background: A substantial proportion of health burden in diabetic individuals can be attributed to cardiovascular complications. The increasing risk of cardiovascular complications along the spectrum of dysglycemia warrants the need to devise novel ...
Ajay Chauhan, Asmita Gupta, Parul Goyal, Tarun Kumar   +3 more
doaj   +1 more source

Laboratory Markers in the Prediction of Premature Birth

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2023
The problem of premature birth (PB) remains topical for the practicing obstetrician-gynecologist. The study of marker proteins indicating an increased risk of PB is one of the relevant areas of interest in modern obstetrics.
Evgenia Igorevna Popova, Andrey Vladimirovich Kozlov, Arina Ilinichna Sizova, Artem Viktorovich Lyamin, Oksana Anatolyevna Gusyakova, Alena Anatolyevna Ereshchenko   +5 more
doaj   +1 more source