Results 1 to 10 of about 22,529,797 (115)
Immunity, 2021 Summary Th17 cells are known to exert both pathogenic and non-pathogenic functions. While the cytokine TGF-β1 is instrumental to Th17 cell differentiation, it is dispensible for the generation of pathogenic-Th17 cells.
Xiaojiang Xu, Mingxia Zhou, Song Zhang
exaly +2 more sources
Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. [PDF]
PLoS ONE, 2015 Deregulated expression of activin A is reported in several tumors, but its biological functions in oral squamous cell carcinoma (OSCC) are unknown. Here, we investigate whether activin A can play a causal role in OSCCs.
Andreia Bufalino +14 more
doaj +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, 2019 Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Leonidas Koniaris +2 more
exaly +2 more sources
BMJ Open Diabetes Research & Care, 2019 Objective Activin A, an inflammatory mediator implicated in cellular senescence-induced adipose tissue dysfunction and profibrotic kidney injury, may become a new target for the treatment of diabetic kidney disease (DKD) and chronic kidney diseases.
Hui Tang +18 more
doaj +2 more sources
Activin a Inhibits BMP-Signaling by Binding ACVR2A and ACVR2B
Cell Communication and Signaling, 2015 Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue.
Oddrun E Olsen +2 more
exaly +2 more sources
Activin A is Not a Reliable Prognostic Biomarker For Bilirubin Induced Neurotoxicity in Neonates [PDF]
Pediatric Sciences Journal (Egypt), 2022 Background: Bilirubin induced neurological dysfunction (BIND) remains an important cause of disability in developing countries. Although high total serum bilirubin (TSB) is the main instigator for BIND, different babies may have different neurological ...
Esraa A. El Mazzahy +4 more
doaj +1 more source
Improved Production of Recombinant Human Activin A in Escherichia coli [PDF]
Journal of Sciences, Islamic Republic of Iran, 2021 Activin A is a member of transforming growth factor β (TGF-β) superfamily. It plays numerous roles in the body such as cell growth regulation and differentiation, wound repairing and modulation of inflammatory responses.
Zahra Hajihassan +2 more
doaj +1 more source
Journal of Cerebral Blood Flow and Metabolism, 2022 Activin A plays an essential role in ischemic stroke as a well-known neuroprotective factor. We previously reported that Activin A could promote white matter remyelination.
Meilian Liu +4 more
semanticscholar +1 more source
Nature Communications, 2021 Pulmonary arterial hypertension is a progressive fatal disease that is characterized by pathological pulmonary artery remodeling, in which endothelial cell dysfunction is critically involved.
G. R. T. Ryanto +9 more
semanticscholar +1 more source
ارزیابی تأثیر فاکتور رشد Activin A و کوچک مولکول IDE1 در تکثیر و خودنوزایی سلول‌های زایای بدوی جوجه در شرایط کشت آزمایشگاهی [PDF]
زیست‌شناسی کاربردی, 2023 مقدمه: چالش اصلی سلول‌ها سلول‌های زایای بدوی (PGC)، عدم تکثیر و خودنوزایی آن‌ها در محیط کشت است. یک روش برای القای پرتوانی سلول‌های PGC، دستکاری مسیرهای پیام‌رسانی درون‌سلولی ازجمله TGF-β است که استفاده از فاکتورهای رشد و کوچک مولکول‌ها یکی از روش‌های ...
معصومه زارع +3 more
doaj +1 more source