Results 31 to 40 of about 158,807,029 (257)

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs.
M. Cangkrama, Mateusz S. Wietecha, Nicolas Mathis, Rin Okumura, L. Ferrarese, D. Al-Nuaimi, M. Antsiferova, R. Dummer, M. Innocenti, S. Werner   +9 more
semanticscholar   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Activin B is produced early in antral follicular development and suppresses thecal androgen production [PDF]

, 2012
Little is known about the role of activin B during folliculogenesis. This study investigated the expression levels of activin/inhibin subunits (βA, βB, and α), steroid enzyme, and gonadotrophin receptors in theca (TC) and granulosa cells (GC) by QPCR and
Young, J M, McNeilly, A S, Henderson, S, Groome, N, Ludlow, H, Souza, C   +5 more
core   +1 more source

Expression of activin subunits and receptors in the developing human ovary:activin A promotes germ cell survival and proliferation before primordial follicle formation [PDF]

, 2004
The formation of the essential functional unit of the ovary, the primordial follicle, occurs during fetal life in humans. Factors regulating oogonial proliferation and interaction with somatic cells before primordial follicle formation are largely ...
Bayne, R A L, Cambray, N, Martins da Silva, S J, Hartley, P S, McNeilly, A S, Martins da Silva, S J; id_orcid, Anderson, R A   +6 more
core   +1 more source

Combined Treatment of Activin A and Heparin Binding-EGF (HB-EGF) Enhances In Vitro Production of Bovine Embryos

Journal of Animal Reproduction and Biotechnology, 2014
This study was carried out to investigate the effects of tissue inhibitor of matalloproteinase-1 (TIMP-1), Activin A and Heparin binding epidermal growth factor (HB-EGF) on In Vitro production of bovine embryos.
Se-woong Kim, Yeon-Gil Jung, Jong-im Park, Sangho Roh   +3 more
doaj   +1 more source

Activins and Activin Receptors in Cell Growth

Experimental Biology and Medicine, 1997
Activin and inhibin, members of transforming growth factor-beta (TGFbeta) superfamily, have diverse and widespread effects within living organisms at many stages during growth and development. From the initial isolation of these growth factors based on their effects of FSH secretion, the study of these factors, as well as of the activin-binding protein
S Y, Ying, Z, Zhang, B, Furst, Y, Batres, G, Huang, G, Li   +5 more
openaire   +2 more sources

Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury

Diagnostics, 2022
Activin is a multifunctional cytokine belonging to the transforming growth factor (TGF)-β superfamily that regulates the growth and differentiation of cells in various organs.
Izumi Nagayama, Akito Maeshima, Daisuke Nagata   +2 more
doaj   +1 more source

Activin regulates betaA-subunit and activin receptor messenger ribonuclic acid and cellular proliferation in activin-responsive testicular tumor cells [PDF]

, 1998
Activin, a member of the transforming growth factor-beta superfamily of growth and differentiation factors, has a number of actions in embryonic as well as adult tissues. These actions are mediated via a family of receptors containing two subtypes and at
Di Simone, Nicoletta, Di Simone N.
core   +1 more source

The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes

Frontiers in Endocrinology, 2022
Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determinant ...
Sarah C. Moody, Sarah C. Moody, Penny A. F. Whiley, Penny A. F. Whiley, Patrick S. Western, Patrick S. Western, Kate L. Loveland, Kate L. Loveland   +7 more
doaj   +1 more source