Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]
, 2017 BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J +6 more
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Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]
, 2018 Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena +5 more
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Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]
Endocrinology, 2011 Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Makanji, Yogeshwar +5 more
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The effect of Activin A and Steroid Hormones on the Recurrent and single Abortion
Tikrit Journal of Pure Science, 2023 This study is designed to evaluate the relationship between Activin -A and the incidence of recurrent and single abortion. The study also included the Estimate of steroid hormones levels (FSH, LH and progesterone concentration through the abortion and ...
Nazar Ahmed Naji, Galawesh Norri Tahrr
doaj +1 more source
Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]
, 2012 Peer reviewedPublisher ...
A Kubo +42 more
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Localization of Activin and Activin Receptors in Rat Spinal Motoneurons
Journal of Biomedical Science, 1996 The purpose of this experiment was to determine whether rat spinal motoneurons (a) produce activin protein and (b) transcribe mRNAs coding for the betaA-subunit of activin and activin receptors II and IIB. The production of activin was determined by immunocytochemistry.
S.-Y., Ying, Z., Zhang, C.K., Haun
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Frontiers in Cardiovascular Medicine, 2022 Activin A has been linked to cardiac dysfunction in aging and disease, with elevated circulating levels found in patients with hypertension, atherosclerosis, and heart failure.
Scott MacDonnell +17 more
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Activin-A: active in inflammation in COPD [PDF]
European Respiratory Journal, 2014 Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow limitation in which chronic inflammation of the airways plays a major role. The persistent inflammation is triggered by inhaled toxic substances, such as cigarette smoke.
Tania, Navessa P. +2 more
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Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer
Biomedicines, 2021 Activin, a member of the TGF-β superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer.
Wanglong Qiu +3 more
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Regulation of reproduction via tight control of gonadotropin hormone levels. [PDF]
, 2018 Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH
Coss, Djurdjica
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