Results 41 to 50 of about 59,531 (261)

Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis [PDF]

, 2017
This work was supported by British Heart Foundation (BHF Project Grant no PG/13/23/30080 to B.A.A and S.H.), Biotechnology and Biological Sciences Research Council (BB/M001695/1 to S.H.) and the University of Aberdeen (for A.T.L).
Afouda, Boni A, De Paiva Alves, Eduardo, Hoppler, Stefan, Lynch, Adam T   +3 more
core   +1 more source

Activin A enhances neurofunctional recovery following traumatic spinal cord injury by inhibiting autophagy

Neural Regeneration Research
In the early stages of traumatic spinal cord injury, extensive accumulation of autophagosomes creates a neurotoxic microenvironment, exacerbating neuronal cell death and worsening tissue damage, ultimately hindering neurofunctional recovery. Activin A is
Liqun Yu, Zhaoyang Yin, Ruiqi Huang, Zhibo Liu, Yuchen Liu, Xinxin Zheng, Simin Song, Zhaojie Wang, Xiaolie He, Yuxin Bai, Li Yang, Xu Xu, Bairu Chen, Jian Yin, Yanjing Zhu   +14 more
doaj   +1 more source

Regulation of the zebrafish goosecoid promoter by mesoderm inducing factors and Xwnt1 [PDF]

, 1996
Goosecoid is a homeobox gene that is expressed as an immediate early response to mesoderm induction by activin. We have investigated the induction of the zebrafish goosecoid promoter by the mesoderm inducing factors activin and basic fibroblast growth ...
Destrée, A. (Anne), Eijnden-van Raaij, A.J.M. (Janny) van den, Fasciana, C. (Claudia), Joore, J. (Jos), Kruijer, M. (Marjan), Laat, S.W. (Siegfried) de, Speksnijder, J.E. (Johanna), Zivkovic, D. (Dana)   +7 more
core   +1 more source

Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Frontiers in Endocrinology, 2023
Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until ...
Penny A. F. Whiley, Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland, Kate L. Loveland   +6 more
doaj   +1 more source

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]

, 2006
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J., Babaie, Y., Brink, T., Burdon, T., Greber, B., Groth, D., Herwig, R., Lehrach, H., Wruck, W.   +8 more
core   +2 more sources

Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells [PDF]

, 1997
To gain more insight in the mechanism of action of inhibin, we studied the effect of inhibin on activin signaling in Chinese hamster ovary cells.
Jong, F.H. (Frank) de, Martens, J.W.M. (John), McLuskey, A., Schaik, R.H.N. (Ron) van, Themmen, A.P.N. (Axel), Timmerman, M.A. (Marianna), Winter, J.P. (Johan) de   +6 more
core   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Transforming growth factor beta–related proteins promote axonal regeneration of injured dorsal root ganglion neurons

Neural Regeneration Research
Dorsal root ganglia neurons gradually lose their axonal regeneration ability during development and aging. To explore molecules that enhance axonal regeneration, we screened growth factors with differential gene expression patterns in the dorsal root ...
Yinying Shen, Peng Yang, Wenyu Dai, Xiaosong Gu, Sheng Yi   +4 more
doaj   +1 more source

Activin A as a Novel Chemokine Induces Migration of L929 Fibroblasts by ERK Signaling in Microfluidic Devices

Frontiers in Cell and Developmental Biology, 2021
Activin A, a member of the transforming growth factor-beta (TGF-β) superfamily, contributes to tissue healing and fibrosis. As the innate tissue cells, fibroblasts also play an important role in wound healing and fibrosis. Herein, this study was aimed to
Lingling Jiang, Lingling Jiang, Yan Qi, Xianghan Kong, Runnan Wang, Jianfei Qi, Francis Lin, Xueling Cui, Zhonghui Liu   +8 more
doaj   +1 more source

Clinical Implication of Targeting of Cancer Stem Cells [PDF]

, 2012
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Al-Hajj M, Bao S, Bardsley MR, Barlogie B, Bentzen SM, Bertout JA, Blazek ER, Bruns CJ, Brunsvig PF, C.J. Bruns, Cao X, Chen MS, Clayton S, Collins AT, Cortes J, Costello R, Dalerba P, Diehn M, Dou J, Dylla SJ, Eyler CE, Fischer S, Garvalov BK, Ghiaur G, Gibbs CP, Gilbert CA, H. Niess, Haferlach T, Hochhaus A, Hosen N, Huff CA, Hurwitz H, Jiang X, Jones RJ, Jones RJ, Jones RJ, Ju Z, K.-W. Jauch, Kanamori M, Kiladjian JJ, Klonisch T, Kojima T, Korpal M, L. Zhao, Li C, Liu G, Liu R, Liu S, Lonardo E, Mauro MJ, McDermott SP, Merante S, Mimeault M, Moserle L, O’Brien SG, Park CY, Phillips TM, Platet N, Q. Bao, Rasheed ZA, Reya T, Reya T, Richardson GD, Roeder I, Seidel S, Singh A, Singh SK, Strojnik T, Stupp R, Suh MR, Szotek PP, Tang C, Tang M, Todaro M, Tu LC, Vermeulen L, Wilson BJ, Wright MH, Xu N, Y. Zhao, Yu F, Zhao C, Zhou BB   +82 more
core   +1 more source