Results 61 to 70 of about 158,807,029 (257)

Therapeutic blockade of Activin-A improves NK cell function and anti-tumor immunity

bioRxiv, 2018
Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metastasis spread. Signals and checkpoints that regulate NK cell fitness and function in the tumor microenvironment are not well ...
J. Rautela, L. Dagley, I. Schuster, S. Hediyeh-zadeh, R. Del Conte, J. Cursons, R. Hennessy, D. S. Hutchinson, C. Harrison, C. D. de Oliveira, É. Vivier, A. Webb, M. Degli-Esposti, M. Davis, N. Huntington, F. Souza-Fonseca-Guimaraes   +15 more
semanticscholar   +1 more source

Activin A enhances neurofunctional recovery following traumatic spinal cord injury by inhibiting autophagy

Neural Regeneration Research
In the early stages of traumatic spinal cord injury, extensive accumulation of autophagosomes creates a neurotoxic microenvironment, exacerbating neuronal cell death and worsening tissue damage, ultimately hindering neurofunctional recovery. Activin A is
Liqun Yu, Zhaoyang Yin, Ruiqi Huang, Zhibo Liu, Yuchen Liu, Xinxin Zheng, Simin Song, Zhaojie Wang, Xiaolie He, Yuxin Bai, Li Yang, Xu Xu, Bairu Chen, Jian Yin, Yanjing Zhu   +14 more
doaj   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Activin a suppresses peripheral CD8+ T lymphocyte activity in acute-phase Kawasaki disease

BMC Immunology, 2021
Background Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old.
Qian Wu, Ruohang Weng, Yongbin Xu, Linlin Wang, Yanyan Huang, Jun Yang   +5 more
doaj   +1 more source

The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A‐Dependent

Journal of Bone and Mineral Research, 2017
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder that is characterized by episodic yet cumulative heterotopic ossification (HO) in skeletal muscles, tendons, and ligaments over a patient's lifetime.
J. Upadhyay, Li-Qin Xie, Lily Huang, Nanditha Das, R. C. Stewart, Morgan Lyon, Keryn Palmer, Saathyaki Rajamani, Chris Graul, Merryl Lobo, T. Wellman, Edward J. Soares, Matthew D. Silva, J. Hesterman, Li-Li Wang, Xia-Ling Wen, Xiaobing Qian, Kalyan C. Nannuru, V. Idone, A. Murphy, A. Economides, Sarah J. Hatsell   +21 more
semanticscholar   +1 more source

Effect of Activin A on In Vitro Development of Rat Preantral Follicles and Localization of Activin A and Activin Receptor II [PDF]

Biology of Reproduction, 2001
Preantral follicles (140-160 microm) were isolated mechanically from the ovaries of 10-day-old rats and cultured in groups of four to six for 6 days in medium containing 0, 1, 10, or 100 ng/ml of activin A. Activin stimulated (P < 0.05) the growth of preantral follicles in a dose-dependent fashion and enhanced the proliferation of preantral, oocyte ...
Yu-Zhao, J., Taverne, M.A.M., van der Weijden, G.C., Bevers, M.M., van den Hurk, R.   +4 more
openaire   +3 more sources

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Exploration of novel activin A antibodies [PDF]

The transforming growth factor β (TGF-β) superfamily comprises the most structurally diverse family of growth factors and plays critical roles in embryogenesis and tissue homeostasis.

core   +2 more sources

Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Frontiers in Endocrinology, 2023
Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until ...
Penny A. F. Whiley, Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland, Kate L. Loveland   +6 more
doaj   +1 more source

Defined Matrices Reveal Epithelial‐ and Mesenchymal‐Specific Responses to Stiffness and Adhesion in Human iPSC‐Derived Intestinal Organoids

Advanced Materials, EarlyView.
Defined PEG hydrogels enable human iPSC‐derived intestinal organoid culture without Matrigel. PEG‐ and Matrigel‐cultured organoids both support duodenal‐like epithelial identity, but direct comparison reveals subtle epithelial differentiation‐marker shifts and stronger mesenchymal ECM‐remodeling/integrin programs in PEG.
Alicja Kuziola, Tamara Fawzi, Emma H. Kromann, Marion Leleu, Joanna M. Drelinkiewicz, Dusko Ilic, Cécile A. Dreiss, Joana F. Neves, Eileen Gentleman   +8 more
wiley   +1 more source