Results 81 to 90 of about 59,531 (261)

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model

Endocrine Journal
Activin A promotes the development of endometriotic lesions in a murine model of endometriosis, and the immunohistochemical localization of phosphorylated suppressor of mothers against decapentaplegic homolog 2/3 (pSMAD2/3) complex in endometriotic ...
Yuri Kadota, Takeshi Kato, Kana Kasai, Takako Kawakita, Misaki Murayama, Akari Shinya, Hikari Sasada, Sachiko Katayama, Mari Nii, Shota Yamamoto, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Miyu Taniguchi, Tomotaka Nakagawa, Takashi Kaji, Masato Nishimura, Riyo Kinouchi, Kanako Yoshida, Takeshi Iwasa   +19 more
doaj   +1 more source

Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.

Reproductive Biology and Endocrinology, 2003
Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state level of activin type I receptor (ActRI) mRNA in
Leung Peter CK, Peng Chun, Chen Victor TS   +2 more
doaj   +1 more source

Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis [PDF]

, 1993
To contribute to an understanding of the roles and mechanisms of action of Wnts in early vertebrate development, we have characterized the normal expression of Xenopus laevis Wnt-5A, and investigated the consequences of misexpression of this putative ...
Campbell, Robert M., Christian, Jan L., Fraser, Scott E., McGrew, L. Lynn, Moon, Randall T., Shih, John   +5 more
core  

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

15-deoxy-Δ12,14-prostaglandin J2 Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF-κB and MAPK Signaling in HepG2 Cells

PPAR Research, 2013
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells. We examined both the mechanism by which 15d-PGJ2 regulates the transcription of activin-induced activin ...
Seung-Won Park, Chunghee Cho, Byung-Nam Cho, Youngchul Kim, Tae Won Goo, Young Il Kim   +5 more
doaj   +1 more source

Multi-Cancer Computational Analysis Reveals Metastasis-Associated Variant of Desmoplastic Reaction Involving INHBA and THBS2 [PDF]

, 2010
Despite extensive research, the details of the metastasis-associated biological mechanisms are largely unknown. Here, we analyze data from multiple cancers using a novel computational method identifying sets of genes whose coordinated overexpression ...
Dimitris Anastassiou, Hoon Kim, John Watkinson, Vinay Varadan   +3 more
core   +1 more source

Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer [PDF]

, 2016
BACKGROUND: Activin-A may exert pro- or anti-tumorigenic activities depending on cellular context. However, little is known about its role, or the other mature activin proteins, in colorectal carcinoma (CRC). This study measured the expression of activin
Adel Galal El-Shemi, Amr Mohamed Mohamed, Bassem Refaat, Jawwad Ahmad, Osama Adnan Kensara, Shakir Idris   +5 more
core   +1 more source

Activin A and activin receptors in gestational tissue from preeclamptic pregnancies [PDF]

Journal of Endocrinology, 2001
Maternal serum activin A levels are elevated in women with preeclampsia. To explore whether this could be due, at least in part, to increased production by the gestational tissues, we have measured activin A in the serum of women with (n=23) or without preeclampsia (n=62) at 29-40 weeks of gestation and in placenta and fetal membranes from preterm ...
U, Manuelpillai, M, Schneider-Kolsky, A, Dole, E M, Wallace   +3 more
openaire   +2 more sources

Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis [PDF]

, 2011
Our laboratory’s previous microarray analysis of subjects with Plasmodium falciparum revealed up-regulation of Toll-like receptor, NF-kB, TNF-α, IFN-γ, IL-1β, p38 MAPK, and MHC molecules.
Alan Scott, Anne Jedlicka, August Louis Bourgeois, Nathan Wolfe, Sher Singh, Wan-Chung(Wan-Jiung) Hu   +5 more
core   +1 more source