Results 81 to 90 of about 158,807,029 (257)

Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids

Molecular Metabolism, 2023
Objective: The liver is a central regulator of energy metabolism exerting its influence both through intrinsic processing of substrates such as glucose and fatty acid as well as by secreting endocrine factors, known as hepatokines, which influence ...
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes, Emily A. Jordan, Alexis R. White, Stephen E. Flaherty, Barbara Bernardo, Trenton Ross, Kendra K. Bence, Morris J. Birnbaum   +10 more
doaj   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Total activin A in maternal blood as a marker of preterm delivery in low-risk asymptomatic patients

, 2006
OBJECTIVES: To retrospectively evaluate whether increased serum levels of total activin A (t-activin A) are found in women who subsequently experience preterm delivery (PTD).
Lambert Messerlian GM, Gabrielli S, FARINA, ANTONIO, Tempesta A, RIZZO, NICOLA, CONCU, MANUELA, MORANO, DANILA, BANZOLA, IRINA, CARLETTI, ANGELA, Canick JA   +9 more
core   +1 more source

Activin/follistatin system in grass carp pituitary cells: - Regulation by local release of growth hormone and luteinizing hormone and its functional role in growth hormone synthesis and secretion.

PLoS ONE, 2017
Gonadotrophin regulation by activin/follistatin system is well-documented, but the corresponding effect on growth hormone (GH) has not been fully characterized and with little information available in lower vertebrates, especially in fish models.
Roger S K Fung, Jin Bai, Karen W Y Yuen, Anderson O L Wong   +3 more
doaj   +1 more source

Activin A is increased in the nucleus accumbens following a cocaine binge

Scientific Reports, 2017
Drug addiction is a long-lasting disease characterized by compulsive drug intake mediated in part by neuronal and biological adaptations in key brain areas, such as the nucleus accumbens (NAc).
Zi-Jun Wang, Jennifer A. Martin, A. Gancarz, Danielle N. Adank, F. Sim, David M. Dietz   +5 more
semanticscholar   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Activin A: a possible marker for liver transplant outcome

, 2004
Activin A, a homodimeric protein consisting of two ßA subunit, is a member of the transforming growth factor-beta (TGF-ß) superfamily. This protein is involved in different physiological process: regulation of pituitary gonadotrophin secretion ...
LUISI, S., DONINI, A., GIOFFRE', W., BACCARANI, U., PETRAGLIA, F., Petraglia, Felice   +5 more
core   +1 more source

A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis. [PDF]

, 2019
Metastasis is a main cause of death in prostate cancer (PCa). To dissect the molecular cues from cancer cell-microenvironment interaction that drive metastatic cascade, bone metastatic PCa cells were intravenously implanted into zebrafish embryos and ...
Thalmann, George N., George N. Thalmann, Arwin Groenewoud, Lanpeng Chen, Marta De Menna, Groenewoud, Arwin, B. Ewa Snaar-Jagalska, Snaar-Jagalska, B Ewa, Chen, Lanpeng, De Menna, Marta, Kruithof-de Julio, Marianna, Marianna Kruithof-de Julio, Groenewoud, A., Chen L, Snaar-Jagalska BE, Thalmann, G.N., Kruithof-de Julio M, Snaar-Jagalska, B.E., De Menna, M., Groenewoud A, Thalmann GN, Kruithof-de Julio, M., De Menna M, Chen, L.   +23 more
core   +1 more source

Structure and activation of pro-activin A

Nature Communications, 2016
Activins are growth factors with multiple roles in the development and homeostasis. Like all TGF-β family of growth factors, activins are synthesized as large precursors from which mature dimeric growth factors are released proteolytically.
Xue-Lu Wang, G. Fischer, M. Hyvönen
semanticscholar   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source