Results 91 to 100 of about 158,807,029 (257)

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

Science Translational Medicine, 2015
In patients with fibrodysplasia ossificans progressiva, the disease-causing mutation changes the ligand response profile of the ACVR1 receptor so that it is activated by the normally antagonistic ligand activin A.
S. Hatsell, V. Idone, Dana M. Alessi Wolken, Lily Huang, H. Kim, Li-Li Wang, Xia-Ling Wen, Kalyan C. Nannuru, Johanna Jimenez, Li-Qin Xie, Nanditha Das, G. Makhoul, Rostislav Chernomorsky, David D’Ambrosio, R. A. Corpina, C. Schoenherr, Kieran Feeley, Paul B. Yu, G. Yancopouloš, A. Murphy, A. Economides   +20 more
semanticscholar   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

, 2008
Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the TGF-superfamily have been shown to be involved in the regulation of bone mass. Activin A, a TGF- signaling ligand, is present
Canalis, Ernesto, Cornwall-Brady, Milton, Seehra, Jasbir, Grinberg, Asya, Bouxsein, Mary L., Stadmeyer, Lisa, Pearsall, R. Scott, Haigis, Brendan, Underwood, Kathryn W., Ucran, Jeffrey, Kumar, Ravindra, Smith, Deanna, Werner, Eric D., Pobre, Eileen, Glatt, Vaida   +14 more
core   +1 more source

Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling [PDF]

, 2013
Regeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not.
Wenemoser, Danielle, Reddien, Peter, Michael A Gaviño, Gavino, Michael A., Wang, Irving E., Irving E Wang, Peter W Reddien, Danielle Wenemoser   +7 more
core   +1 more source

Activin-A Induces Fewer, but Larger Osteoclasts From Monocytes in Both Healthy Controls and Fibrodysplasia Ossificans Progressiva Patients

Frontiers in Endocrinology, 2020
Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease characterized by heterotopic ossification (HO) that occurs in muscle tissue, tendons, and ligaments.
Ton Schoenmaker, Esmée Botman, Merve Sariyildiz, Dimitra Micha, Coen Netelenbos, Nathalie Bravenboer, Angele Kelder, E. Marelise W. Eekhoff, Teun J. De Vries   +8 more
doaj   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source

In vitro release of activin A from human normal and pathological thyroid tissues

, 2001
Activin A is a dimeric glycoprotein belonging to the transforming growth factor beta (TGF-beta) superfamily characterized by the ability to affect FSH secretion.
A. Spada, A. Corsi, P. S. Morpurgo, S. Corbetta, L. Vicentini   +4 more
core   +1 more source

Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model

Endocrine Journal
Activin A promotes the development of endometriotic lesions in a murine model of endometriosis, and the immunohistochemical localization of phosphorylated suppressor of mothers against decapentaplegic homolog 2/3 (pSMAD2/3) complex in endometriotic ...
Yuri Kadota, Takeshi Kato, Kana Kasai, Takako Kawakita, Misaki Murayama, Akari Shinya, Hikari Sasada, Sachiko Katayama, Mari Nii, Shota Yamamoto, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Miyu Taniguchi, Tomotaka Nakagawa, Takashi Kaji, Masato Nishimura, Riyo Kinouchi, Kanako Yoshida, Takeshi Iwasa   +19 more
doaj   +1 more source

Activin A and follistatin in patients with nonalcoholic fatty liver disease

Metabolism: Clinical and Experimental, 2016
Objective There are limited data on the role of activin A and its binding protein, follistatin, in nonalcoholic fatty liver disease (NAFLD). The main aim was the evaluation of serum activin A and follistatin levels in patients with biopsy-proven NAFLD vs.
S. Polyzos, J. Kountouras, A. Anastasilakis, Georgios A Triantafyllou, C. Mantzoros   +4 more
semanticscholar   +1 more source