Results 51 to 60 of about 158,807,029 (257)

Activin A more prominently regulates muscle mass in primates than does GDF8

Nature Communications, 2017
Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man.
E. Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, H. Okamoto, Katie Cavino, Erqian Na, A. Papatheodorou, T. Willer, Yu Bai, Jee Hae Kim, A. Rafique, S. Jaspers, T. Stitt, A. Murphy, G. Yancopouloš, J. Gromada   +18 more
semanticscholar   +1 more source

High levels of fetal membrane activin ßA and activin receptor IIB mRNAs and augmented concentration of amniotic fluid activin A in women in term or preterm labor

, 1997
The aim of the present study was to evaluate whether spontaneous labor at term and pathological preterm labor are associated with changes in the expression of activin A and activin receptor mRNAs in fetal membranes.
FLORIO, P., VALE, W. W., GENAZZANI, A. R, DI BLASIO, A. M., WOODRUFF, T. K., PETRAGLIA, F.   +5 more
core   +2 more sources

Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification

Cells, 2021
A current hypothesis is that transforming growth factor-β signaling ligands, such as activin-A and myostatin, play a role in vascular damage in atherosclerosis and chronic kidney disease (CKD).
Pasquale Esposito, Daniela Verzola, Daniela Picciotto, Leda Cipriani, Francesca Viazzi, Giacomo Garibotto   +5 more
doaj   +1 more source

Circulating Activin A predicts survival in cancer patients

Journal of Cachexia, Sarcopenia and Muscle, 2017
Several experimental evidences pinpoint the possible role of Activin A (ActA) as a driver of cancer cachexia. Supporting this hypothesis, we showed recently that human cancer cachexia is associated with high ActA levels.
A. Loumaye, M. de Barsy, M. Nachit, P. Lause, A. van Maanen, P. Tréfois, D. Gruson, J. Thissen   +7 more
semanticscholar   +1 more source

Activin A and Sertoli Cells: Key to Fetal Testis Steroidogenesis

, 2022
The long-standing knowledge that Sertoli cells determine fetal testosterone production levels is not widespread, despite being first reported over a decade ago in studies of mice.
Loveland, Kate L, Whiley, Penny A. F., Whiley, Penny AF, Loveland, Kate L., O'Donnell, Liza, O’Donnell, Liza   +5 more
core   +1 more source

Peritubular myoid cells from immature rat testes secrete activin-A and express activin receptor type II in vitro [PDF]

, 1994
The expression of activin type II and IIB receptors and inhibin alpha-, beta A-, and beta B-subunit messenger RNAs (mRNAs), and the secretion of immunoreactive and bioactive activin during culture of testicular peritubular ...
Timmerman, M.A. (Marianna), Vanderstichele, H.M.J. (Hugo), Verhoeven, G., Winter, J.P. (Johan) de, Wesseling, J.G., Jong, F.H. (Frank) de   +5 more
core   +1 more source

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Science Signaling, 2019
Activin-A inhibits NK cell effector functions and suppresses antimelanoma immunity. Enhancing NK cells Natural killer (NK) cells are innate immune cells with a critical role in antitumor immunity.
J. Rautela, L. Dagley, C. de Oliveira, I. Schuster, S. Hediyeh-zadeh, R. Del Conte, J. Cursons, R. Hennessy, Dana S. Hutchinson, C. Harrison, Badia Kita, Eric Vivier, A. Webb, M. Degli-Esposti, Melissa J. Davis, N. Huntington, Fernando Souza-Fonseca-Guimarães   +16 more
semanticscholar   +1 more source

Expression of activin A.

, 2014
Activin A expression was determined using anti-activin A antibodies (goat polyclonal; 1∶50; R&D Systems; Minneapolis, MN, USA). A. Case 17; infected endophthalmitis.
Hidetoshi Yamashita (641923), Yoshiko Kashiwagi (641919), Hiroyuki Namba (641920), Mari Narumi (641918), Mitsunori Yamakawa (641922), Rintaro Ohe (641921)   +5 more
core   +1 more source

Transforming growth factor beta–related proteins promote axonal regeneration of injured dorsal root ganglion neurons

Neural Regeneration Research
Dorsal root ganglia neurons gradually lose their axonal regeneration ability during development and aging. To explore molecules that enhance axonal regeneration, we screened growth factors with differential gene expression patterns in the dorsal root ...
Yinying Shen, Peng Yang, Wenyu Dai, Xiaosong Gu, Sheng Yi   +4 more
doaj   +1 more source

Activin A Stimulates Migration of the Fallopian Tube Epithelium, an Origin of High-Grade Serous Ovarian Cancer, through Non-Canonical Signaling

Cancer Letters, 2017
Factors that stimulate the migration of fallopian tube epithelial (FTE)-derived high-grade serous ovarian cancer (HGSOC) to the ovary are poorly elucidated.
M. Dean, David A. Davis, Joanna E. Burdette   +2 more
semanticscholar   +1 more source