Results 21 to 30 of about 32,159 (165)
Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]
Endocrinology, 2011 Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Makanji, Yogeshwar +5 more
openaire +4 more sources
Czech Journal of Animal Science, 2010 To improve the culture system of bovine somatic cell nuclear transfer (SCNT) embryos, we studied the effects of activin A on developmental competence of bovine SCNT embryos during the early development stage based on the traditional culture method, and ...
S. Hua +7 more
doaj +1 more source
Activin-A: active in inflammation in COPD [PDF]
European Respiratory Journal, 2014 Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow limitation in which chronic inflammation of the airways plays a major role. The persistent inflammation is triggered by inhaled toxic substances, such as cigarette smoke.
Tania, Navessa P. +2 more
openaire +2 more sources
The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes
Frontiers in Endocrinology, 2022 Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determinant ...
Sarah C. Moody +7 more
doaj +1 more source
Role of stromal activin A in human pancreatic cancer and metastasis in mice
Scientific Reports, 2021 Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in colon cancer and its stroma but its role in the stroma of PDAC has not been ...
Georgina Mancinelli +11 more
doaj +1 more source
The effect of Activin A and Steroid Hormones on the Recurrent and single Abortion
Tikrit Journal of Pure Science, 2023 This study is designed to evaluate the relationship between Activin -A and the incidence of recurrent and single abortion. The study also included the Estimate of steroid hormones levels (FSH, LH and progesterone concentration through the abortion and ...
Nazar Ahmed Naji, Galawesh Norri Tahrr
doaj +1 more source
Localization of Activin and Activin Receptors in Rat Spinal Motoneurons
Journal of Biomedical Science, 1996 The purpose of this experiment was to determine whether rat spinal motoneurons (a) produce activin protein and (b) transcribe mRNAs coding for the betaA-subunit of activin and activin receptors II and IIB. The production of activin was determined by immunocytochemistry.
S.-Y., Ying, Z., Zhang, C.K., Haun
openaire +2 more sources
Frontiers in Cardiovascular Medicine, 2022 Activin A has been linked to cardiac dysfunction in aging and disease, with elevated circulating levels found in patients with hypertension, atherosclerosis, and heart failure.
Scott MacDonnell +17 more
doaj +1 more source
Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer
Biomedicines, 2021 Activin, a member of the TGF-β superfamily, is involved in many physiological processes, such as embryonic development and follicle development, as well as in multiple human diseases including cancer.
Wanglong Qiu +3 more
doaj +1 more source
Neural Regeneration ResearchDorsal root ganglia neurons gradually lose their axonal regeneration ability during development and aging. To explore molecules that enhance axonal regeneration, we screened growth factors with differential gene expression patterns in the dorsal root ...
Yinying Shen +4 more
doaj +1 more source