Results 21 to 30 of about 158,807,029 (257)

Activin A backs-up TGF-ß to promote regulatory T cells

OncoImmunology, 2021
The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by ...
Mara De Martino, Camille Daviaud, Claire Vanpouille-Box   +2 more
doaj   +1 more source

Different Immunoregulation Roles of Activin A Compared With TGF-β

Frontiers in Immunology, 2022
Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also
Fanglin Li, Fanglin Li, Yiru Long, Yiru Long, Xiaolu Yu, Xiaolu Yu, Yongliang Tong, Yongliang Tong, Likun Gong, Likun Gong, Likun Gong   +10 more
doaj   +1 more source

Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling

Scientific Reports, 2020
Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical biophysical role in cancer progression, but the precise pro-metastatic
J. Bauer, M. A. Emon, Jonas J. Staudacher, Alexandra Thomas, Jasmin Zessner-Spitzenberg, Georgina Mancinelli, N. Krett, M. Saif, B. Jung   +8 more
semanticscholar   +1 more source

An Easy And Fast Method For Production Of Chinese Hamster Ovary Cell Line Expressing And Secreting Human Recombinant Activin A [PDF]

Cell Journal, 2020
Objective Growth factors are key elements of embryonic stem cell (ESC) research. Cell line development in eukaryotes is a time-consuming procedure which usually takes 12-18 months. Here, we report an easy and fast method with which production of Chinese
Hassan Rassouli, Ali Sayadmanesh, Siamak Rezaeiani, Zahra Ghezelayagh, Mohammad Reza Gharaati, Tahamtani Yaser   +5 more
doaj   +1 more source

Antagonism of Activin by Activin Chimeras [PDF]

, 2011
Activins are pluripotent hormones/growth factors that belong to the TGF-β superfamily of growth and differentiation factors (GDFs). They play a role in cell growth, differentiation and apoptosis, endocrine function, metabolism, wound repair, immune responses, homeostasis, mesoderm induction, bone growth, and many other biological processes.
Uwe, Muenster, Radhika, Korupolu, Ratindra, Rastogi, Jessica, Read, Wolfgang H, Fischer   +4 more
openaire   +2 more sources

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

eLife, 2020
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC).
S. Aykul, R. A. Corpina, E. J. Goebel, C. Cunanan, Alexandra Dimitriou, H. Kim, Qian Zhang, A. Rafique, Raymond W. Leidich, Xin Wang, J. Mcclain, Johanna Jimenez, Kalyan C. Nannuru, Nyanza J. Rothman, John B. Lees-Shepard, E. Martinez-Hackert, A. Murphy, T. Thompson, A. Economides, V. Idone   +19 more
semanticscholar   +1 more source

Activin B promotes the initiation and progression of liver fibrosis

Hepatology Communications, 2022
The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis.
Yan Wang, Matthew Hamang, Alexander Culver, Huaizhou Jiang, Jennifer Yanum, Veronica Garcia, Joonyong Lee, Emily White, Praveen Kusumanchi, Naga Chalasani, Suthat Liangpunsakul, Benjamin C. Yaden, Guoli Dai   +12 more
doaj   +1 more source

Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]

Endocrinology, 2011
Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Makanji, Yogeshwar, Walton, Kelly L., Chan, Karen L., Gregorevic, Paul, Robertson, David M., Harrison, Craig A.   +5 more
openaire   +4 more sources

Effect of activin A on migration and adhesion of breast cancer 4T1 cells

Zhongguo gonggong weisheng, 2023
ObjectiveTo explore the effect of activin A on the migration and adhesion of murine breast cancer 4T1 cells. MethodsThe viability of in vitro cultured 4T1 cells was studied using the 3- (4,5-dimethyl-2-thiazyl)-2,5-diphenyl-2h-tetrazolium bromide (MTT ...
Linjing ZHU, Yunlong ZHAO, Shumi SHANG, Fang FANG, Hongyu WANG, Yujia ZOU, Xueling CUI   +6 more
doaj   +1 more source

Activin A promotes regulatory T cell–mediated immunosuppression in irradiated breast cancer

Cancer immunology research, 2020
Activin A and TGFβ can shape the breast cancer tumor microenvironment after radiotherapy. Dual blockade of activin A and TGFβ reverses radiotherapy-induced Treg increases and boosts antitumor responses, highlighting potential targetable factors for ...
M. De Martino, C. Daviaud, Julie M. Diamond, J. Kraynak, A. Alard, S. Formenti, L. Miller, S. Demaria, C. Vanpouille-Box   +8 more
semanticscholar   +1 more source