Results 11 to 20 of about 32,159 (165)
Activin A backs-up TGF-ß to promote regulatory T cells
OncoImmunology, 2021 The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by ...
Mara De Martino +2 more
doaj +1 more source
Different Immunoregulation Roles of Activin A Compared With TGF-β
Frontiers in Immunology, 2022 Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also
Fanglin Li +10 more
doaj +1 more source
An Easy And Fast Method For Production Of Chinese Hamster Ovary Cell Line Expressing And Secreting Human Recombinant Activin A [PDF]
Cell Journal, 2020 Objective Growth factors are key elements of embryonic stem cell (ESC) research. Cell line development in eukaryotes is a time-consuming procedure which usually takes 12-18 months. Here, we report an easy and fast method with which production of Chinese
Hassan Rassouli +5 more
doaj +1 more source
Antagonism of Activin by Activin Chimeras [PDF]
, 2011 Activins are pluripotent hormones/growth factors that belong to the TGF-β superfamily of growth and differentiation factors (GDFs). They play a role in cell growth, differentiation and apoptosis, endocrine function, metabolism, wound repair, immune responses, homeostasis, mesoderm induction, bone growth, and many other biological processes.
Uwe, Muenster +4 more
openaire +2 more sources
Activin B promotes the initiation and progression of liver fibrosis
Hepatology Communications, 2022 The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis.
Yan Wang +12 more
doaj +1 more source
Effect of activin A on migration and adhesion of breast cancer 4T1 cells
Zhongguo gonggong weisheng, 2023 ObjectiveTo explore the effect of activin A on the migration and adhesion of murine breast cancer 4T1 cells. MethodsThe viability of in vitro cultured 4T1 cells was studied using the 3- (4,5-dimethyl-2-thiazyl)-2,5-diphenyl-2h-tetrazolium bromide (MTT ...
Linjing ZHU +6 more
doaj +1 more source
Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. [PDF]
PLoS ONE, 2015 Deregulated expression of activin A is reported in several tumors, but its biological functions in oral squamous cell carcinoma (OSCC) are unknown. Here, we investigate whether activin A can play a causal role in OSCCs.
Andreia Bufalino +14 more
doaj +1 more source
Activins and Activin Receptors in Cell Growth
Experimental Biology and Medicine, 1997 Activin and inhibin, members of transforming growth factor-beta (TGFbeta) superfamily, have diverse and widespread effects within living organisms at many stages during growth and development. From the initial isolation of these growth factors based on their effects of FSH secretion, the study of these factors, as well as of the activin-binding protein
S Y, Ying +5 more
openaire +2 more sources
Journal of Animal Reproduction and Biotechnology, 2014 This study was carried out to investigate the effects of tissue inhibitor of matalloproteinase-1 (TIMP-1), Activin A and Heparin binding epidermal growth factor (HB-EGF) on In Vitro production of bovine embryos.
Se-woong Kim +3 more
doaj +1 more source
Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury
Diagnostics, 2022 Activin is a multifunctional cytokine belonging to the transforming growth factor (TGF)-β superfamily that regulates the growth and differentiation of cells in various organs.
Izumi Nagayama +2 more
doaj +1 more source