Results 11 to 20 of about 59,531 (261)

A Novel Signal Peptide Derived from Bacillus Licheniformis α-Amylase Efficiently Targets Recombinant Human Activin A to the Periplasm of Escherichia coli [PDF]

Journal of Cell and Molecular Research, 2018
Human activin A is a member of the transforming growth factor-β superfamily consists of two similar beta subunits. Activin A is expressed by different cells and displays numerous biological activities such as control of neuronal cell proliferation and ...
Zahra Hajihassan, Seyed kazem Hosseini, Alireza Zomorodipour   +2 more
doaj   +1 more source

Activin A backs-up TGF-ß to promote regulatory T cells

OncoImmunology, 2021
The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by ...
Mara De Martino, Camille Daviaud, Claire Vanpouille-Box   +2 more
doaj   +1 more source

Different Immunoregulation Roles of Activin A Compared With TGF-β

Frontiers in Immunology, 2022
Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also
Fanglin Li, Fanglin Li, Yiru Long, Yiru Long, Xiaolu Yu, Xiaolu Yu, Yongliang Tong, Yongliang Tong, Likun Gong, Likun Gong, Likun Gong   +10 more
doaj   +1 more source

Antagonism of Activin by Activin Chimeras [PDF]

, 2011
Activins are pluripotent hormones/growth factors that belong to the TGF-β superfamily of growth and differentiation factors (GDFs). They play a role in cell growth, differentiation and apoptosis, endocrine function, metabolism, wound repair, immune responses, homeostasis, mesoderm induction, bone growth, and many other biological processes.
Uwe, Muenster, Radhika, Korupolu, Ratindra, Rastogi, Jessica, Read, Wolfgang H, Fischer   +4 more
openaire   +2 more sources

An Easy And Fast Method For Production Of Chinese Hamster Ovary Cell Line Expressing And Secreting Human Recombinant Activin A [PDF]

Cell Journal, 2020
Objective Growth factors are key elements of embryonic stem cell (ESC) research. Cell line development in eukaryotes is a time-consuming procedure which usually takes 12-18 months. Here, we report an easy and fast method with which production of Chinese
Hassan Rassouli, Ali Sayadmanesh, Siamak Rezaeiani, Zahra Ghezelayagh, Mohammad Reza Gharaati, Tahamtani Yaser   +5 more
doaj   +1 more source

Not All Weight Loss Is Equal: Towards Muscle-Preserving Therapies in Obesity. [PDF]

J Cachexia Sarcopenia Muscle
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
Abraham JD, Khan MS, Anker SD.
europepmc   +2 more sources

Activin B promotes the initiation and progression of liver fibrosis

Hepatology Communications, 2022
The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis.
Yan Wang, Matthew Hamang, Alexander Culver, Huaizhou Jiang, Jennifer Yanum, Veronica Garcia, Joonyong Lee, Emily White, Praveen Kusumanchi, Naga Chalasani, Suthat Liangpunsakul, Benjamin C. Yaden, Guoli Dai   +12 more
doaj   +1 more source

Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. [PDF]

PLoS ONE, 2015
Deregulated expression of activin A is reported in several tumors, but its biological functions in oral squamous cell carcinoma (OSCC) are unknown. Here, we investigate whether activin A can play a causal role in OSCCs.
Andreia Bufalino, Nilva K Cervigne, Carine Ervolino de Oliveira, Felipe Paiva Fonseca, Priscila Campioni Rodrigues, Carolina Carneiro Soares Macedo, Lays Martin Sobral, Marcia Costa Miguel, Marcio Ajudarte Lopes, Adriana Franco Paes Leme, Daniel W Lambert, Tuula A Salo, Luiz Paulo Kowalski, Edgard Graner, Ricardo D Coletta   +14 more
doaj   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Recombinant human activin A promotes development of bovine somatic cell nuclear transfer embryos matured in vitro

Czech Journal of Animal Science, 2010
To improve the culture system of bovine somatic cell nuclear transfer (SCNT) embryos, we studied the effects of activin A on developmental competence of bovine SCNT embryos during the early development stage based on the traditional culture method, and ...
S. Hua, J. Lan, Y.G. Liu, Y.L. Song, J. Liu, Y.S. Wang, T. Zhang, Y. Zhang   +7 more
doaj   +1 more source