Results 81 to 90 of about 5,391 (252)

The role of activins and follistatins in skin and hair follicle development and function

, 2008
Investigations of the signalling between epithelial and mesenchymal compartments of skin during hair follicle initiation in utero and hair cycling have revealed the importance of the TGFbeta superfamily in ectodermal organogenesis and morphogenesis.
M. McDowall, P.I. Hynd, Edwards, N., N.M. Edwards, McDowall, M., Hynd, P., Jahoda, C., C.A.B. Jahoda   +7 more
core   +1 more source

Activin A in Mammalian Physiology [PDF]

Physiological Reviews, 2019
Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian ...
Bloise E, Ciarmela P, Dela Cruz C, Luisi S, Petraglia F, Reis FM   +5 more
openaire   +4 more sources

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome

BMC Pulmonary Medicine, 2019
Background We aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).
Jee-min Kim, Jung-Kyu Lee, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee   +10 more
doaj   +1 more source

Activins regulate 17β-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells

, 2009
Activins are pleiotropic members of the TGFβ superfamily and were initially characterized based on their abilities to stimulate FSH synthesis and secretion by gonadotrope cells of the anterior pituitary gland.
Bak, Beata, Mayo, Kelly E., Hardy, Matthew P., Bernard, Daniel J., Ge, Renshan, Carpio, Laura, Lamba, Pankaj, Wang, Ying, Kipp, Jinjing L.   +8 more
core   +1 more source

The role of activins in hepcidin regulation during malaria [PDF]

, 2017
Epidemiological observations have linked increased host iron with malaria susceptibility, and perturbed iron handling has been hypothesized to contribute to the potentially life threatening anemia that may accompany blood-stage malaria infection.
Armitage, AE, Choudhary, P, Hodgson, Susanne H., Hodgson, SH, Draper, Simon J., Drakesmith, Alexander, Biswas, S, Llewyllyn, D, Draper, SJ, Spottiswoode, N, Duffy, PE, Armitage, Andrew E., Fyfe, AJ, Williams, AR, Drakesmith, AH   +14 more
core   +2 more sources

Human follicle-stimulating hormone β subunit expression depends on FOXL2 and SMAD4

, 2020
Follicle-stimulating hormone (FSH), an essential regulator of mammalian fertility, is synthesized by pituitary gonadotrope cells in response to activins.
Boehm, U., Deng, C.X., Kumar, T.R., Bernard, D.J., Ongaro, L., Zhou, Z., Schang, G., Treier, M.   +7 more
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

TGF‐β Inhibition Attenuates Tau Accumulation and Neurodegeneration in Progressive Supranuclear Palsy Patient‐Derived Organoids

Movement Disorders, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a devastating 4‐repeat tauopathy with no approved disease‐modifying treatments. Recent evidence showed increased transforming growth factor‐β (TGF‐β) levels in PSP patient‐derived ventral midbrain organoids (vMOs) and serum neuronally derived exosomes. Objective This study investigated whether
Mariagrazia Talarico, Andrea Quattrone, Giorgia Lucia Benedetto, Raffaele Covello, Maurizio Martini, Valeria Zuccalà, Giovanni Cuda, Elvira Immacolata Parrotta, Aldo Quattrone   +8 more
wiley   +1 more source