Physiology of activins/follistatins: associations with metabolic and anthropometric variables and response to exercise [PDF]
, 2018 Context: Clinical trials are evaluating the efficacy of inhibitors of the myostatin pathway in neuromuscular and metabolic diseases. Activins and follistatins are major regulators of the myostatin pathway, but their physiology in relation to metabolic ...
Perakakis N., Mougios V., Fatouros I., Siopi A., Draganidis D., Peradze N., Ghaly W., Mantzoros C.S.
core +1 more source
Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension
Scientific Reports, 2022 Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors.
Sachindra R. Joshi +20 more
doaj +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Activins and activin receptors in the rat testis [PDF]
, 1994 Inhibin and activin are gonadal protein hormones, which were originally defined by their negative and positive feedback action on the release of follicle stimulating hormone (FSH) from the pituitary gland.
Winter, J.P. (Johan) de
core
Metabolic regulation of activins in healthy individuals and in obese patients undergoing bariatric surgery [PDF]
, 2020 Objective: Follistatin binds and inactivates activins, which are potent inhibitors of muscle growth and metabolism and are currently being developed for the treatment of obesity and type 2 diabetes (T2D).
Peradze, N. +7 more
core
Follistatin and activins in polycystic ovary syndrome: relationship to metabolic and hormonal markers [PDF]
, 2013 ObjectivePolycystic ovary syndrome (PCOS) is common and has reproductive and metabolic manifestations. Activin A and follistatin levels remain controversial and activin B levels are unstudied in PCOS.
Ng, S. +7 more
core +1 more source
Activin B can signal through both ALK4 and ALK7 in gonadotrope cells
Reproductive Biology and Endocrinology, 2006 Background Activins stimulate pituitary FSH synthesis via transcriptional regulation of the FSHbeta subunit gene (Fshb). Like other members of the TGFbeta superfamily, these ligands signal through complexes of type I and type II receptor serine/threonine
Lee Katharine B +2 more
doaj +1 more source
Molecular Metabolism, 2020 Objective: Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In preclinical animal models, blocking activin receptor (ACVR) ligands has improved survival and prevented muscle wasting in cancer cachexia without an ...
J.J. Hulmi +12 more
doaj +1 more source
Activin A in Mammalian Physiology [PDF]
Physiological Reviews, 2019 Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian ...
Bloise E +5 more
openaire +4 more sources
WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. [PDF]
PLoS ONE, 2010 Female germ cells are essential for organogenesis of the ovary; without them, ovarian follicles do not form and functional and structural characteristics of the ovary are lost.
Chia-Feng Liu +2 more
doaj +1 more source