Results 101 to 110 of about 4,991 (262)
Pediatric Discovery, EarlyView.MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen +11 more
wiley +1 more source
Review Article Activins and Follistatin in Chronic Hepatitis C and Its Treatment with Pegylated-Interferon-Based Therapy [PDF]
, 2020 Pegylated-interferon-based therapy for the treatment of chronic hepatitis C (CHC) is considered suboptimal as not all patients respond to the treatment and it is associated with several side effects that could lead to dose reduction and/or termination of
Esam Azhar +3 more
core
Targeting activins to counteract muscle wasting and cachexia [PDF]
, 2017 Cancer cachexia is a condition of severe frailty and fatigue, associated with the loss of skeletal muscle and fat mass. Cachexia constitutes a major unmet medical challenge, as up to 80% of patients with advanced cancers exhibit cachectic symptoms, and ...
Chen, Justin (3796126)
core +1 more source
Pathomechanisms of Autoimmune Based Testicular Inflammation
Frontiers in Immunology, 2020 Infection and inflammation of the male reproductive tract are relevant causes of infertility. Inflammatory damage occurs in the special immunosuppressive microenvironment of the testis, a hallmark termed testicular immune privilege, which allows ...
Livia Lustig +14 more
doaj +1 more source
Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications
Portal Hypertension &Cirrhosis, EarlyView.This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf +8 more
wiley +1 more source
Small, EarlyView.Ultraviolet photoacoustic microscopy enables label‐free visualization of nuclear morphology in intact human brain organoids. By exploiting endogenous nucleic acid absorption at 266 nm, this approach resolves individual nuclei without staining or sectioning.
Hyunjun Kye +5 more
wiley +1 more source
Journal of Immunology Research, 2014 The transforming growth factor-β (TGF-β) superfamily is a family of structurally related proteins that includes TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs).
Belen Tirado-Rodriguez +3 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei +6 more
wiley +1 more source
Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators [PDF]
, 2008 Myostatin is a secreted TGF-\u3b2 family member that controls skeletal muscle growth. Humans, cattle, and dogs carrying natural loss-of-function mutations in the myostatin gene and myostatin knockout mice exhibit significant increases in skeletal muscle ...
Guo, Yongjing +7 more
core +1 more source
Avoiding pitfalls when modelling ligands in macromolecular crystallography
Acta Crystallographica Section D, EarlyView.Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart +4 more
wiley +1 more source