Results 111 to 120 of about 5,391 (252)

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

INHBB Promotes Colorectal Cancer Progression by Inducing CD8+ T Cell Exhaustion via the ACVR2B‐SMAD Signaling Axis

Cancer Science, EarlyView.
INHBB secreted by colorectal cancer cells activates ACVR2B‐SMAD signaling to induce CD8+ T‐cell exhaustion and drive tumor progression. SB431542 blocks this oncogenic immune‐suppressive axis. ABSTRACT To investigate the expression pattern, biological functions and regulatory mechanisms of inhibin beta B (INHBB) in colorectal cancer (CRC), and to ...
Guanghui Liu, Yuanhua Liu, Hongchao Zhao, Junfeng Sun, Hongwei Yang, Qingqing Ding   +5 more
wiley   +1 more source

Antiviral activity of bone morphogenetic proteins and activins [PDF]

, 2018
Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling.
Webber, Caleb, Vukicevic, Slobodan, Crowe, John, Giordani, Maria Teresa, Chung, Raymond T., McHugh, Peter J., Al-Hourani, Kinda, Sandor, Cynthia, Owens, Benjamin M. J., Giannoulatou, Eleni, Babitt, Jodie L., Drakesmith, Hal, Ryan, John D., Sun, Chia Chi, Fabris, Paolo, Boninsegna, Sara, Frankish, Jamie, Fusco, Dahlene N., Rehwinkel, Jan, Klenerman, Paul, Armitage, Andrew E., Martines, Diego, Binder, Marco, Lawless, Matthew W., Eddowes, Lucy A., Lin, Herbert Y., Ramamurthy, Narayan, Baddock, Hannah T, Chevaliez, Stephane, Arezes, João   +29 more
core   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Intrapituitary interactions: Another level of endocrine regulation

, 2001
The definitive version is available at www.blackwell-synergy.com1. Factors, produced within the anterior pituitary, act locally to influence many acute and developmental changes in neighbouring cells. 2.
Schwartz, Jeffrey, Jeff Schwartz
core   +1 more source

BCL2 Facilitates Naïve Pluripotency and an 8C‐Like State in Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
BCL2 stabilizes human naïve pluripotency associated with H3K27ac modulation and induces 8CLCs in human naïve ESCs. ABSTRACT Human naïve embryonic stem cells (ESCs) can spontaneously transition into 8‐cell‐like cells (8CLCs), a cell state that recapitulates the totipotent features of the 8‐cell‐stage embryo.
Zhimin Lu, Han Wu, Xiaomin Su, Hua Yu, Fang Yang, Siqin Bao, Xihe Li, Baojiang Wu   +7 more
wiley   +1 more source

Targeting Activins to treat cachexia

This project will examine Activins, as contributing factors to the loss of lean and fat mass that is commonly observed in patients with advanced cancer, and evaluate the therapeutic prospects of administering novel engineered Activin inhibitors, to ...

core   +1 more source

Activins and prolactinoma development I: Sexual differences

, 2018
Activins are members of the transforming growth factor beta (TGFβ) family of proteins. They are biologically active as dimers and, besides their known function on pituitary gonadotrophs, activins (A and B) also modulate lactotroph population, being ...
Diaz, Graciela Susana, Abeledo Machado, Alejandra Inés, Faraoni, Erika Yanil, Camilletti, María Andrea, Rulli, Susana Beatriz, Marcial López, Carla Agustina   +5 more
core  

Weight Regain After Incretin Treatment: The Lean Mass Deficit Hypothesis and a Role for Testosterone Combination Therapy in Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann, Zsolt Bosnyak, Richard Jones, Monica Caliber   +3 more
wiley   +1 more source

Potential roles for endometrial inhibins, activins and follistatin during human embryo implantation and early pregnancy

, 2002
The human endometrium is a remarkably dynamic tissue, undergoing cycles of proliferation, differentiation and breakdown every 28 days. In preparation for embryo implantation, the endometrium differentiates or decidualizes, involving widespread ...
Rebecca L Jones, Findlay, Jock K., Jock K Findlay, Jones, Rebecca L., Salamonsen, Lois A., Lois A Salamonsen   +5 more
core   +1 more source