Results 111 to 120 of about 4,991 (262)
Inhibins Tune the Thymocyte Selection Process by Regulating Thymic Stromal Cell Differentiation
Journal of Immunology Research, 2015 Inhibins and Activins are members of the TGF-β superfamily that regulate the differentiation of several cell types. These ligands were initially identified as hormones that regulate the hypothalamus-pituitary-gonadal axis; however, increasing evidence ...
Ebzadrel Carbajal-Franco +4 more
doaj +1 more source
Adaptation of the invasive pest Drosophila suzukii to a specialized nutritional niche
Insect Science, EarlyView.Unlike most Drosophila larvae that feed on spoiled food, Drosophila suzukii larvae thrive on ripening fruits and consequently face a low‐protein, high‐carbohydrate nutritional challenge. Comparisons of growth among D. suzukii, D. biarmipes, and D. melanogaster larvae across diets with varying protein‐to‐carbohydrate ratios demonstrate that D.
Yan Hou, Ying Zhen
wiley +1 more source
Activins as candidate cholinergic differentiation factors in vivo [PDF]
, 1995 A number of cytokine families have been implicated in shaping neuronal survival, growth and gene expression. The neuropoietic and transforming growth factor-β (TGF-β) cytokines, in particular, have emerged as candidates for regulating the phenotype of ...
Fann, Ming-Ji, Patterson, Paul H.
core
The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models
Journal of Skin Cancer, 2012 TGFβ1 is a member of a large growth factor family including activins/inhibins and bone morphogenic proteins (BMPs) that have a potent growth regulatory and immunomodulatory functions in normal skin homeostasis, regulation of epidermal stem cells ...
Adam B. Glick
doaj +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Targeting Activins to treat cachexia [PDF]
This project will examine Activins, as contributing factors to the loss of lean and fat mass that is commonly observed in patients with advanced cancer, and evaluate the therapeutic prospects of administering novel engineered Activin inhibitors, to ...
core
Allergy, EarlyView.Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider +48 more
wiley +1 more source
مجلة كلية الطبBackground: An ectopic pregnancy occurs when a fertilized egg implants itself—typically in one of the fallopian tubes—outside of the womb. Connecting the ovaries to the womb are tubes called fallopian tubes.
Hussein Al-Rkaby +2 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo +3 more
wiley +1 more source