Results 31 to 40 of about 5,391 (252)

Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation. [PDF]

PLoS ONE, 2016
Lung transplantation exposes the donated lung to a period of anoxia. Re-establishing the circulation after ischemia stimulates inflammation causing organ damage.
David M de Kretser, Jonathan G Bensley, David J Phillips, Bronwyn J Levvey, Greg I Snell, Enjarn Lin, Mark P Hedger, Robyn E O'Hehir   +7 more
doaj   +1 more source

Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice

iScience, 2021
Summary: Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients.
Takayuki Ozawa, Masato Morikawa, Yasuyuki Morishita, Kazuki Ogikubo, Fumiko Itoh, Daizo Koinuma, Per-Åke Nygren, Kohei Miyazono   +7 more
doaj   +1 more source

Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model. [PDF]

PLoS ONE, 2017
Fractures still present a significant burden to patients due to pain and periods of unproductivity. Numerous growth factors have been identified to regulate bone remodeling.
Tero Puolakkainen, Petri Rummukainen, Jemina Lehto, Olli Ritvos, Ari Hiltunen, Anna-Marja Säämänen, Riku Kiviranta   +6 more
doaj   +1 more source

Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways

BMC Biology, 2022
Background Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases.
Szabina Szófia Szilágyi, Ayelet R. Amsalem-Zafran, Keren E. Shapira, Marcelo Ehrlich, Yoav I. Henis   +4 more
doaj   +1 more source

Correlations between activins and follistatin.

, 2016
Correlations between activins and follistatin.
David J. Phillips (2182534), David M. de Kretser (163697), Greg I. Snell (392912), Bronwyn J. Levvey (392911), Jonathan G. Bensley (381442), Enjarn Lin (797206), Mark P. Hedger (2182532), Robyn E. O’Hehir (2182536)   +7 more
core   +1 more source

Activin Actions in Adipocytes.

J Clin Endocrinol Metab
Abstract Obesity is a growing global health problem characterized by excess fat accumulation. Though causes of obesity are multifactorial, glucagon-like peptide 1 receptor agonists have emerged as effective weight loss drugs. Nevertheless, these agents are expensive, not uniformly available, and must be used continuously.
Ongaro L, Bernard DJ.
europepmc   +3 more sources

Structure and activation of pro-activin A

Nature Communications, 2016
Activins are members of the TGF-β family of growth factors that are processed from precursors into the mature proteins. Here, the authors use structural biology and biochemistry to examine the protein domain organisation and gain insights into the ...
Xuelu Wang, Gerhard Fischer, Marko Hyvönen   +2 more
doaj   +1 more source

The orphan ligand, activin C, signals through activin receptor-like kinase 7

eLife, 2022
Activin ligands are formed from two disulfide-linked inhibin β (Inhβ) subunit chains. They exist as homodimeric proteins, as in the case of activin A (ActA; InhβA/InhβA) or activin C (ActC; InhβC/InhβC), or as heterodimers, as with activin AC (ActAC ...
Erich J Goebel, Luisina Ongaro, Emily C Kappes, Kylie Vestal, Elitza Belcheva, Roselyne Castonguay, Ravindra Kumar, Daniel J Bernard, Thomas B Thompson   +8 more
doaj   +1 more source

Is sotatercept, which traps activins and growth differentiation factors, a new dawn in treating pulmonary arterial hypertension (PAH)?

, 2023
INTRODUCTION: Although the prevalence of pulmonary arterial hypertension (PAH) is low, mortality is high. In PAH, there is a down-regulation of the bone morphogenetic protein receptor type 2 pathway, leading to a prominence of the upregulation pathway ...
Doggrell, Sheila A
core   +1 more source

Elevated expression of activins promotes muscle wasting and cachexia

, 2014
Elevated expression of activins promotes muscle wasting and ...
Kelly L Walton (13599535), Rachel E Thomson (19242634), Yogeshwar Makanji (1562494), Justin L Chen (13599532), Catherine E Winbanks (19242628), Paul Gregorevic (294694), Kate Murphy (13086459), Gordon S Lynch (13620712), Hongwei Qian (294693), Craig A Harrison (13599550)   +9 more
core   +2 more sources