Table1_Profiling Activins and Follistatin in Colorectal Cancer According to Clinical Stage, Tumour Sidedness and Smad4 Status.DOCX [PDF]
, 2021 This study explored the roles of activins and follistatin in colorectal cancers. Paired malignant and normal colonic tissues were collected from archived paraffin-embedded (n = 90 patients) alongside fresh (n = 40 patients) specimen cohorts.
Jamal Zekri (11717870) +14 more
core +1 more source
Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan
International Journal of Inflammation, 2014 Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin ...
Jun Yamada +7 more
doaj +1 more source
Activin signaling as an emerging target for therapeutic interventions
Cell Communication and Signaling, 2009 After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activities including the regulation of gonadal ...
Ageta Hiroshi +6 more
doaj +1 more source
Image1_Profiling Activins and Follistatin in Colorectal Cancer According to Clinical Stage, Tumour Sidedness and Smad4 Status.JPEG [PDF]
, 2021 This study explored the roles of activins and follistatin in colorectal cancers. Paired malignant and normal colonic tissues were collected from archived paraffin-embedded (n = 90 patients) alongside fresh (n = 40 patients) specimen cohorts.
Jamal Zekri (11717870) +14 more
core +1 more source
Physiological roles of activins in the human ovary
Journal of Bio-X Research, 2018 . Initially discovered in the pituitary as stimulators of follicle stimulating hormone, activins are homo- or heterodimers of inhibin subunits, which belong to the transforming growth factor-β superfamily.
Hsun-Ming Chang, Peter C.K. Leung
doaj +1 more source
Localization of Activin and Activin Receptors in Rat Spinal Motoneurons
Journal of Biomedical Science, 1996 The purpose of this experiment was to determine whether rat spinal motoneurons (a) produce activin protein and (b) transcribe mRNAs coding for the betaA-subunit of activin and activin receptors II and IIB. The production of activin was determined by immunocytochemistry.
S.-Y., Ying, Z., Zhang, C.K., Haun
openaire +2 more sources
Intra-ovarian roles of activins and inhibins [PDF]
, 2012 Granulosa cells are the main ovarian source of inhibins, activins and activin-binding protein (follistatin) while germ (oogonia, oocytes) and somatic (theca, granulosa, luteal) cells express activin receptors, signaling components and inhibin co-receptor
Phil G. Knight +5 more
core +1 more source
Follistatin attenuates radiation-induced fibrosis in a murine model. [PDF]
PLoS ONE, 2017 PURPOSE:Fibrosis can be a disabling, severe side effect of radiotherapy that can occur in patients, and for which there is currently no effective treatment.
Helen B Forrester +4 more
doaj +1 more source
Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation. [PDF]
PLoS ONE, 2016 Lung transplantation exposes the donated lung to a period of anoxia. Re-establishing the circulation after ischemia stimulates inflammation causing organ damage.
David M de Kretser +7 more
doaj +1 more source
iScience, 2021 Summary: Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients.
Takayuki Ozawa +7 more
doaj +1 more source