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Activins and Activin Receptors in Cell Growth
Activin and inhibin, members of transforming growth factor-beta (TGFbeta) superfamily, have diverse and widespread effects within living organisms at many stages during growth and development. From the initial isolation of these growth factors based on their effects of FSH secretion, the study of these factors, as well as of the activin-binding protein
S Y, Ying +5 more
openaire +2 more sources
Correlations between activins and follistatin. [PDF]
Correlations between activins and follistatin.
David J. Phillips (2182534) +7 more
core +1 more source
Inhibins and activins are dimeric ligands belonging to the TGFβ superfamily with emergent roles in cancer. Inhibins contain an α-subunit (INHA) and a β-subunit (either INHBA or INHBB), while activins are mainly homodimers of either βA (INHBA) or βB ...
Eduardo Listik +5 more
doaj +1 more source
Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide [PDF]
Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased tissues.
Makanji, Yogeshwar +5 more
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Activins as Regulators of Branching Morphogenesis [PDF]
Development of glandular organs such as the kidney, lung, and prostate involves the process of branching morphogenesis. The developing organ begins as an epithelial bud that invades the surrounding mesenchyme, projecting dividing epithelial cords or ...
Risbridger, Gail P., Ball, Emma M.A.
core +1 more source
Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release.
nancy murray (6884852)
core +1 more source
Activin-A: active in inflammation in COPD [PDF]
Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow limitation in which chronic inflammation of the airways plays a major role. The persistent inflammation is triggered by inhaled toxic substances, such as cigarette smoke.
Tania, Navessa P. +2 more
openaire +2 more sources
Activins, follistatin and immunoregulation in the epididymis [PDF]
Background: The interface between the epididymis and the immune system is implicated in many male reproductive pathologies. The resident immune cell populations and immune-environment within the epididymis are significantly different from the testis ...
M. P. Hedger +3 more
core +1 more source
Elevated expression of activins promotes muscle wasting and cachexia [PDF]
Elevated expression of activins promotes muscle wasting and ...
Kelly L Walton (13599535) +9 more
core +3 more sources
Human immunodeficiency virus type 1 (HIV-1) infection triggers rapid induction of multiple innate cytokines including type I interferons, which play important roles in viral control and disease pathogenesis.
Matthew Dickinson +10 more
doaj +1 more source

