Results 1 to 10 of about 6,991 (98)

Follistatin-Like Proteins: Structure, Functions and Biomedical Importance

Biomedicines, 2021
Main forms of cellular signal transmission are known to be autocrine and paracrine signaling. Several cells secrete messengers called autocrine or paracrine agents that can bind the corresponding receptors on the surface of the cells themselves or their ...
Olga K. Parfenova, Vladimir G. Kukes, Dmitry V. Grishin   +2 more
doaj   +3 more sources

Potential new biomarkers in pig saliva for differentiating between the effects of different conditions of mixing and density at pre-slaughter: a preliminary proteomics study [PDF]

Animal Welfare
The intensification of pig (Sus scrofa domesticus) production systems raises concerns regarding animal welfare, particularly during pre-slaughter conditions, a phase associated with significant stress.
María Botía, Alberto Muñoz-Prieto, Alba Ortín Bustillo, Dina Rešetar-Maslov, Ivana Rubić, Pablo Fuentes, Francisco J. Jiménez-Caparrós, Juan L. Hernández-Gómez, Antonio Avellaneda, Jose Joaquin Ceron, Fernando Tecles, Vladimir Mrljak, Damián Escribano   +12 more
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Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus [PDF]

Frontiers in Neurology
BackgroundHydrocephalus comprises etiologically heterogeneous disorders that converge on ventricular enlargement but may be associated with distinct protein-abundance patterns within the cerebrospinal fluid (CSF) compartment.
Hao Han, Xun Xie, Mingchen Xie, Yahui Zhang, Jianhua Cheng, Jian Xu   +5 more
doaj   +2 more sources

Identification of Differential Expression Cytokines in Hemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome by Proteome Microarray Analysis and Further Verification

Cell Transplantation, 2021
To screen the differential expression cytokines (DECs) in hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome, establish its differential cytokines spectra, and provide the clues for its diagnosis and pathogenic mechanism researches ...
Suya Kang, Liping Zhou, Yun Wang, Hui Li, Hong Zhang   +4 more
doaj   +1 more source

Baicalin attenuates LPS-induced alveolar type II epithelial cell A549 injury by attenuation of the FSTL1 signaling pathway via increasing miR-200b-3p expression

Innate Immunity, 2021
In China, baicalin is the main active component of Scutellaria baicalensis , which has been used in the treatment of inflammation-related diseases, such as inflammation-induced acute lung injury. However, its specific mechanism remains unclear.
Xin-ya Duan, Yang Sun, Zhu-fen Zhao, Yao-qing Shi, Xun-yan Ma, Li Tao, Ming-wei Liu   +6 more
doaj   +1 more source

Characterization of Insulin-like Peptide (ILP) and Its Potential Role in Ovarian Development of the Cuttlefish Sepiella japonica

Current Issues in Molecular Biology, 2022
The insulin-like peptide (ILP) family is well known for regulating reproduction in invertebrates, while its role in mollusks remains largely unknown. In this study, we first isolated and characterized the ILP gene in the cuttlefish Sepiella japonica. The
Zhenming Lü, Chenghao Yao, Shijie Zhao, Yao Zhang, Li Gong, Bingjian Liu, Liqin Liu   +6 more
doaj   +1 more source

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Frontiers in Endocrinology, 2021
Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases.
Shehla Pervin, Shehla Pervin, Srinivasa T. Reddy, Srinivasa T. Reddy, Rajan Singh, Rajan Singh, Rajan Singh   +6 more
doaj   +1 more source

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

Scientific Reports, 2021
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity.
Ellen F. Mosleth, Christian Alexander Vedeler, Kristian Hovde Liland, Anette McLeod, Gerd Haga Bringeland, Liesbeth Kroondijk, Frode Steingrimsen Berven, Artem Lysenko, Christopher J. Rawlings, Karim El-Hajj Eid, Jill Anette Opsahl, Bjørn Tore Gjertsen, Kjell-Morten Myhr, Sonia Gavasso   +13 more
doaj   +1 more source

Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

Frontiers in Physiology, 2020
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic and complex endocrine organ, which produces and secretes several adipokines, including hormones, cytokines, extracellular matrix (ECM) proteins, and growth and ...
Lucia Recinella, Giustino Orlando, Claudio Ferrante, Annalisa Chiavaroli, Luigi Brunetti, Sheila Leone   +5 more
doaj   +1 more source

Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma

BMC Medicine, 2023
Background Multiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with causal genetic evidence offers a chance to uncover novel therapeutic targets.
Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu, Jian Hou   +4 more
doaj   +1 more source