Results 1 to 10 of about 6,859 (161)

Follistatin-Like Proteins: Structure, Functions and Biomedical Importance

Biomedicines, 2021
Main forms of cellular signal transmission are known to be autocrine and paracrine signaling. Several cells secrete messengers called autocrine or paracrine agents that can bind the corresponding receptors on the surface of the cells themselves or their ...
Olga K. Parfenova, Vladimir G. Kukes, Dmitry V. Grishin   +2 more
doaj   +3 more sources

Maternal Serum Activin A, Inhibin A and Follistatin-Related Proteins across Preeclampsia: Insights into Their Role in Pathogenesis and Prediction. [PDF]

J Mother Child, 2023
Within the endocrine-paracrine signalling network at the maternal-foetal interface, the activin-inhibin-follistatin system modulates extravillous trophoblast invasion, suggesting a potential role in preeclampsia pathogenesis. This study aimed to compile the evidence published in the last decade regarding the variation in maternal serum activins ...
Barrero JA, Villamil-Camargo LM, Imaz JN, Arciniegas-Villa K, Rubio-Romero JA.   +4 more
europepmc   +3 more sources

Potential new biomarkers in pig saliva for differentiating between the effects of different conditions of mixing and density at pre-slaughter: a preliminary proteomics study [PDF]

Animal Welfare
The intensification of pig (Sus scrofa domesticus) production systems raises concerns regarding animal welfare, particularly during pre-slaughter conditions, a phase associated with significant stress.
María Botía, Alberto Muñoz-Prieto, Alba Ortín Bustillo, Dina Rešetar-Maslov, Ivana Rubić, Pablo Fuentes, Francisco J. Jiménez-Caparrós, Juan L. Hernández-Gómez, Antonio Avellaneda, Jose Joaquin Ceron, Fernando Tecles, Vladimir Mrljak, Damián Escribano   +12 more
doaj   +2 more sources

Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus [PDF]

Frontiers in Neurology
BackgroundHydrocephalus comprises etiologically heterogeneous disorders that converge on ventricular enlargement but may be associated with distinct protein-abundance patterns within the cerebrospinal fluid (CSF) compartment.
Hao Han, Xun Xie, Mingchen Xie, Yahui Zhang, Jianhua Cheng, Jian Xu   +5 more
doaj   +2 more sources

The Impact of Collection Protocol on the Yield and Purity of Mesenchymal Stem Cell-Derived Extracellular Vesicles Isolated From Serum-Free Media. [PDF]

Biotechnol J
Graphical Abstract and Lay Summary Mesenchymal stem cells (MSCs) were cultured in standard, ultracentrifuged (UC), or starvation serum‐free media to evaluate how medium influences extracellular vesicle (EV) yield and purity. Culture in UC medium improved EV purity but reduced yield.
Phelps J, Tamrin SH, Duncan NA, Sen A.
europepmc   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Human Follistatin-Related Protein: A Structural Homologue of Follistatin with Nuclear Localization [PDF]

Endocrinology, 2001
Follistatin-related protein is a recently discovered glycoprotein that is highly homologous in both primary sequence and exon/intron domain structure to the activin-binding protein, follistatin. We explored their potential for functional redundancy by investigating the relative affinities and kinetics of their interactions with activin, bone ...
D V, Tortoriello, Y, Sidis, D A, Holtzman, W E, Holmes, A L, Schneyer   +4 more
openaire   +3 more sources

Identification of Differential Expression Cytokines in Hemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome by Proteome Microarray Analysis and Further Verification

Cell Transplantation, 2021
To screen the differential expression cytokines (DECs) in hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome, establish its differential cytokines spectra, and provide the clues for its diagnosis and pathogenic mechanism researches ...
Suya Kang, Liping Zhou, Yun Wang, Hui Li, Hong Zhang   +4 more
doaj   +1 more source

Follistatin-Related Protein and Follistatin Differentially Neutralize Endogenous vs. Exogenous Activin [PDF]

Endocrinology, 2002
Follistatin-related protein (FSRP) is a new addition to the expanding follistatin (FS)-related gene family whose members contain at least one conserved 10-cysteine follistatin domain. In contrast to other members of this family, FSRP and follistatin also share a common exon/intron domain structure, substantial primary sequence homology, and an ability ...
Yisrael, Sidis, Drew V, Tortoriello, William E, Holmes, Yang, Pan, Henry T, Keutmann, Alan L, Schneyer   +5 more
openaire   +3 more sources

Baicalin attenuates LPS-induced alveolar type II epithelial cell A549 injury by attenuation of the FSTL1 signaling pathway via increasing miR-200b-3p expression

Innate Immunity, 2021
In China, baicalin is the main active component of Scutellaria baicalensis , which has been used in the treatment of inflammation-related diseases, such as inflammation-induced acute lung injury. However, its specific mechanism remains unclear.
Xin-ya Duan, Yang Sun, Zhu-fen Zhao, Yao-qing Shi, Xun-yan Ma, Li Tao, Ming-wei Liu   +6 more
doaj   +1 more source