Results 1 to 10 of about 867,210 (214)

Maternal Serum Activin A, Inhibin A and Follistatin-Related Proteins across Preeclampsia: Insights into Their Role in Pathogenesis and Prediction. [PDF]

J Mother Child, 2023
Within the endocrine-paracrine signalling network at the maternal-foetal interface, the activin-inhibin-follistatin system modulates extravillous trophoblast invasion, suggesting a potential role in preeclampsia pathogenesis. This study aimed to compile the evidence published in the last decade regarding the variation in maternal serum activins ...
Barrero JA, Villamil-Camargo LM, Imaz JN, Arciniegas-Villa K, Rubio-Romero JA.   +4 more
europepmc   +4 more sources

Potential new biomarkers in pig saliva for differentiating between the effects of different conditions of mixing and density at pre-slaughter: a preliminary proteomics study [PDF]

Animal Welfare
The intensification of pig (Sus scrofa domesticus) production systems raises concerns regarding animal welfare, particularly during pre-slaughter conditions, a phase associated with significant stress.
María Botía, Alberto Muñoz-Prieto, Alba Ortín Bustillo, Dina Rešetar-Maslov, Ivana Rubić, Pablo Fuentes, Francisco J. Jiménez-Caparrós, Juan L. Hernández-Gómez, Antonio Avellaneda, Jose Joaquin Ceron, Fernando Tecles, Vladimir Mrljak, Damián Escribano   +12 more
doaj   +3 more sources

The Non-Linear Profile of Aging: U-Shaped Expression of Myostatin, Follistatin and Intermediate Signals in a Longitudinal In Vitro Murine Cell Sarcopenia Model [PDF]

Proteomes
Sarcopenia is linked to the decline in muscle mass, strength and function during aging. It affects the quality and life expectancy and can lead to dependence.
Janire Alonso-Puyo, Oihane Izagirre-Fernandez, Olatz Crende, Jesús Seco-Calvo, Ainhoa Fernandez-Atutxa, Diego Fernandez-Lazaro, Patricia Garcia-Gallastegi, Begoña Sanz   +7 more
doaj   +3 more sources

The Myostatin Propeptide and the Follistatin-related Gene Are Inhibitory Binding Proteins of Myostatin in Normal Serum [PDF]

Journal of Biological Chemistry, 2002
Myostatin, also known as growth and differentiation factor 8, is a member of the transforming growth factor beta superfamily that negatively regulates skeletal muscle mass (1). Recent experiments have shown that myostatin activity is detected in serum by a reporter gene assay only after activation by acid, suggesting that native myostatin circulates as
Jennifer J, Hill, Monique V, Davies, Adele A, Pearson, Jack H, Wang, Rodney M, Hewick, Neil M, Wolfman, Yongchang, Qiu   +6 more
openaire   +3 more sources

Follistatin-Like Proteins: Structure, Functions and Biomedical Importance

Biomedicines, 2021
Main forms of cellular signal transmission are known to be autocrine and paracrine signaling. Several cells secrete messengers called autocrine or paracrine agents that can bind the corresponding receptors on the surface of the cells themselves or their ...
Olga K. Parfenova, Vladimir G. Kukes, Dmitry V. Grishin   +2 more
doaj   +3 more sources

Differential expression of follistatin and FLRG in human breast proliferative disorders [PDF]

BMC Cancer, 2009
Background Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines.
Amaral Vania F, Grasso Giovanni, Muscettola Michela, Borges Lavinia E, Mencarelli Marzia, Ciarmela Pasquapina, Massai Lauretta, Couto Henrique L, Bloise Enrrico, Cassali Geovanni D, Petraglia Felice, Reis Fernando M   +11 more
doaj   +4 more sources

The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair [PDF]

Journal of Endocrinology, 2001
Follistatin is a secreted protein that binds activin in vitro and in vivo and thereby inhibits its biological functions. Recently, related human and murine genes, designated follistatin-related gene (FLRG), were identified, and their products were shown to bind activin with high affinity.
Wankell M, Kaesler S, Zhang YQ, Florence C, Werner S, Duan R   +5 more
openaire   +4 more sources

Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer [PDF]

BMC Cancer, 2016
BACKGROUND: Activin-A may exert pro- or anti-tumorigenic activities depending on cellular context. However, little is known about its role, or the other mature activin proteins, in colorectal carcinoma (CRC). This study measured the expression of activin
Adel Galal El-Shemi, Amr Mohamed Mohamed, Bassem Refaat, Jawwad Ahmad, Osama Adnan Kensara, Shakir Idris   +5 more
core   +3 more sources

Characterization of a Rat C₆ Glioma‐Secreted Follistatin‐Related Protein (FRP) [PDF]

European Journal of Biochemistry, 1994
A protein was isolated from rat C6 glioma‐conditioned medium and was biochemically characterized. The heparin‐binding protein has a native molecular mass of 55–75000Da, a molecular mass of 40–48000 Da under denaturing conditions, and a pI of 5.0–6.0. Based on the determined partial amino acid sequences, the full lenght cDNA encoding the rat and human ...
Zwijsen, An, Blockx, Herman, Van Arnhem, Wouter, Willems, Jean, Fransen, Lucie, Devos, Kathleen, Raymackers, Jos, Van de Voorde, André, Slegers, Herman   +8 more
openaire   +4 more sources

Follistatin and follistatin-like 3 in metabolic disorders

Prostaglandins and Other Lipid Mediators, 2023
Follistatin (FST) is a glycoprotein which main role is antagonizing activity of transforming growth factor β superfamily members. Folistatin-related proteins such as follistatin-like 3 (FSTL3) also reveal these properties.
Weronika Bielka, Andrzej Pawlik
exaly   +2 more sources