Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size [PDF]
, 2013 Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood.
Abir Mukherjee +54 more
core +1 more source
BMC Cancer, 2008 Background The incidence and mortality of hepatocellular cancer (HCC) complicating alcoholic and non-alcoholic fatty liver diseases (ALD and NAFLD) is rising in western societies.
Trerotoli Paolo +9 more
doaj +1 more source
Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]
, 2020 Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo +16 more
core +1 more source
Chinese Medical Journal, 2021 Abstract Background: Follistatin-like 1 (FSTL1) plays both pro-inflammatory and anti-inflammatory roles in the inflammatory processes. We investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV)-specific indices ...
Taejun Yoon +6 more
openaire +4 more sources
Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO
Frontiers in Physiology, 2018 The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells.
Vincent F. M. Segers +5 more
doaj +1 more source
Ameliorative effects of follistatin‐related protein/TSC‐36/FSTL1 on joint inflammation in a mouse model of arthritis [PDF]
Arthritis & Rheumatism, 2004 AbstractObjectiveTo clarify the in vivo function of follistatin‐related protein (FRP)/TSC‐36/FSTL1 in rheumatoid arthritis (RA), we investigated the roles of FRP in a mouse model of arthritis.MethodsArthritis was induced in BALB/c mice by injecting anti–type II collagen monoclonal antibody and lipopolysaccharide.
Daisuke, Kawabata +7 more
openaire +2 more sources
Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]
, 2014 In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Arriola, David J +4 more
core +8 more sources
Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins [PDF]
, 2005 © The Company of Biologists Ltd 2005Paracrine factors secreted by the oocyte regulate a broad range of cumulus cell functions. Characteristically, cumulus cells have a low incidence of apoptosis and we proposed that this is due to oocyte-secreted factors
Amato, F. +4 more
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Agrin binds to the nerve-muscle basal lamina via laminin [PDF]
, 1997 Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Altschul +73 more
core +3 more sources
Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. [PDF]
, 2017 Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed.
Amatucci, Aldo +16 more
core +2 more sources