Results 41 to 50 of about 6,859 (161)

Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy

Experimental Physiology, EarlyView.
Abstract Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass and function.
Derk H. C. Nieuwenhuijsen, Moritz Eggelbusch, Rob C. I. Wüst   +2 more
wiley   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Association Between EAT‐Lancet Diet Adherence and Sleep Quality in Lactating Women: A Cross‐Sectional Analysis

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims In recent years, the sustainable EAT‐Lancet diet (ELD) has garnered attention for its health benefits, especially regarding mental health and cognitive function. However, its impact on sleep health remains underexplored. This study aims to investigate the relationship between ELD and sleep quality, focusing on lactating ...
Farzam Kamrani, Shima Jafari, Samira Karbasi, Zahra Khorasanchi   +3 more
wiley   +1 more source

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho, Marielle Saclier   +1 more
wiley   +1 more source

Follistatin‐related protein/follistatin‐like 1 evokes an innate immune response via CD14 and toll‐like receptor 4 [PDF]

FEBS Letters, 2012
FRP physically interacts with CD14 by fluorescence‐activated cell sorting (View interaction)
Murakami, Kosaku, Tanaka, Masao, Usui, Takashi, Kawabata, Daisuke, Shiomi, Aoi, Iguchi-Hashimoto, Mikiko, Shimizu, Masakazu, Yukawa, Naoichiro, Yoshifuji, Hajime, Nojima, Takaki, Ohmura, Koichiro, Fujii, Takao, Umehara, Hisanori, Mimori, Tsuneyo   +13 more
openaire   +2 more sources

Dnajb5 From Antarctic Fish Reveals a Redox‐Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho, Min‐Kyung Choi, Mi‐Ock Baek, Hyeon‐Hee Son, Binh Thanh Nguyen, Min‐Jung Kang, Il‐Chan Kim, Jin‐Hyoung Kim, Mee‐Sup Yoon   +8 more
wiley   +1 more source

Maternal plasma levels of follistatin‐related gene protein in the first trimester of pregnancies with Down syndrome

Prenatal Diagnosis, 2010
AbstractObjectiveTo determine maternal plasma levels of follistatin‐related gene protein (FLRG) in the first trimester of pregnancy and assess its potential role as a marker for prenatal screening of Down syndrome.MethodsMaternal plasma levels of FLRG were determined in 100 pregnant women with normal fetuses in their first trimester of pregnancy (i.e ...
Miron, P., Lambert, J., Marcil, A., Cowans, N. J., Stamatopoulou, A., Spencer, K.   +5 more
openaire   +3 more sources

Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP

Reproductive Biology and Endocrinology, 2009
Background NASP (Nuclear Autoantigenic Sperm Protein) is a linker histone chaperone required for normal cell division. Changes in NASP expression significantly affect cell growth and development; loss of gene function results in embryonic lethality ...
Alekseev Oleg, Richardson Richard T, Alekseev Oleg M, O'Rand Michael G   +3 more
doaj   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source