Results 61 to 70 of about 12,023,937 (197)
Advanced Science, Volume 13, Issue 62, 9 November 2026.Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi +11 more
wiley +1 more source
Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan [PDF]
, 2014 Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin ...
Takeshi Muneta +7 more
core +1 more source
Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
wiley +1 more source
Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E2 in cultured granulosa-luteal cells [PDF]
Molecular Human Reproduction, 2002 Activin and its binding protein follistatin may act as local regulators of cell growth and steroidogenesis in the human ovary. The recently identified follistatin-related gene (FLRG) is expressed abundantly in the human ovary, has high affinity for activin, and is able to inhibit activin-induced transcriptional responses. However, little is known about
J, Liu +3 more
openaire +2 more sources
Reproductive Biology and Endocrinology, 2009 Background NASP (Nuclear Autoantigenic Sperm Protein) is a linker histone chaperone required for normal cell division. Changes in NASP expression significantly affect cell growth and development; loss of gene function results in embryonic lethality ...
Alekseev Oleg +3 more
doaj +1 more source
MedComm, Volume 7, Issue 11, November 2026.This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin +6 more
wiley +1 more source
Prenatal Diagnosis, 2010 AbstractObjectiveTo determine maternal plasma levels of follistatin‐related gene protein (FLRG) in the first trimester of pregnancy and assess its potential role as a marker for prenatal screening of Down syndrome.MethodsMaternal plasma levels of FLRG were determined in 100 pregnant women with normal fetuses in their first trimester of pregnancy (i.e ...
Miron, P. +5 more
openaire +3 more sources
Potential preventive effects of follistatin-related protein/TSC-36 on joint destruction and antagonistic modulation of its autoantibodies in rheumatoid arthritis [PDF]
International Immunology, 2003 We previously reported that follistatin-related protein (FRP)/TSC-36 was one of the target antigens of autoantibodies in rheumatoid arthritis (RA) and that the appearance of serum autoantibodies to FRP correlated to disease activity in RA. However, the significance of FRP in autoimmunity remained to be explained due to the unknown function of FRP. Here,
Masao, Tanaka +8 more
openaire +2 more sources
Aging Cell, Volume 25, Issue 11, November 2026.Aging orchestrates a dWAT–MCP‐1–CCR2 axis that recruits and reprograms macrophage subpopulations, disrupting the local M1/M2 balance and suppressing WNT signaling, thereby impairing both hair cycle transition and production of genes associated with melanogenesis.
Jian Chen +13 more
wiley +1 more source
Different effect of follistatin-related protein (FRP)in ox-LDLinduced endothelial cell and vascular smooth muscle cell apoptosis [PDF]
Heart, 2011 Background The development of atherosclerosis proceeds through multiple maladaptive pathways that begins with endothelial cell (EC)injury caused by oxidised low-density lipoprotein (ox-LDL) which plays a critical role. Proliferation and migration of vascular smooth muscle cells (VSMCs) also play an important role in
null Shenhua +8 more
openaire +1 more source