Results 71 to 80 of about 12,023,937 (197)

Fibro‐Adipogenic Progenitors From Skeletal Muscle Enhance Microvascular Angiogenesis in a 3D Model

Advanced Biology, Volume 10, Issue 10, October 2026.
Fibro‐adipogenic progenitors (FAPs) are skeletal muscle stem cells that reside between fibers and near capillaries. However, relatively few studies have investigated interactions between FAPs and the microvasculature. We demonstrate that FAPs enhance angiogenesis of microvascular fragments (MVFs) by promoting increases in vessel percentage area and ...
Christian M. Mendiondo, Andrew R. King, Felipe Morales, David Leyton‐Cifuentes, Theodore J. Pabst, Eric M. Brey, Christopher R. Rathbone   +6 more
wiley   +1 more source

Protein expression and linear correlation (D, E) of activin A (A), Follistatin (B) and TGF-beta1 (C) in nasal tissue from CRSsNP (n = 13), CRSwNP (n = 23) and Control patients (inferior turbinate) (n = 10).

, 2015
The figures show that the expression of all three proteins (Activin A, Follistatin and TGF-ß1) were higher in CRSsNP than in CRSwNP; Follistatin protein was positively correlated with activin A protein in CRSsNP and in CRSwNP.
Feng Lan (548104), Suling Hong (582864), Guohua Hu (582862), Koen Van Crombruggen (394435), Nan Zhang (46264), Claus Bachert (154290), Yucheng Yang (747796)   +6 more
core   +1 more source

Follistatin attenuates radiation-induced fibrosis in a murine model. [PDF]

, 2017
PURPOSE:Fibrosis can be a disabling, severe side effect of radiotherapy that can occur in patients, and for which there is currently no effective treatment.
De Kretser, David M., De Kretser, DM, David M. de Kretser, Forrester, Helen B., Leong, T, Trevor Leong, Hagekyriakou, Jim, Helen B. Forrester, Forrester, HB, Sprung, CN, Jim Hagekyriakou, Leong, Trevor, Helen B Forrester, Carl N Sprung, Sprung, Carl N., David M de Kretser, Carl N. Sprung, Hagekyriakou, J, Leong Trevor, Forrester Helen B., de Kretser David M., Hagekyriakou Jim, Sprung Carl N.   +22 more
core   +2 more sources

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian, Yanji Tong, Fang Yu, Xiaoming Hu   +3 more
wiley   +1 more source

Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis

, 2004
Follistatin is known to antagonise the function of several members of the TGF-beta family of secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growth characterised to date. In this study, we compare the expression of
Kambadur, R, Mridula Sharma, Sharma, M, Amthor, H, Nicholas, G, C.Fred Kemp, Ravi Kambadur, Iain McKinnell, Gina Nicholas, Ketan Patel, Patel, K, Helge Amthor, McKinnell, I w, Kemp, CF, Patel, K., Sharma, M., Nicholas, G., McKinnell, I., Amthor, H., Kambadur, R., Kemp, C. F.   +20 more
core   +1 more source

Prognostic Significance of Proteomics‐Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pulmonary arterial hypertension (PAH) ultimately leads to right ventricular failure and premature death. The identification of circulating biomarkers with prognostic utility is considered a priority.
Tetsuro Yokokawa, Olivier Boucherat, Sandra Martineau, Sarah‐Eve Lemay, Sandra Breuils‐Bonnet, Vinod Krishna, Shanker Kalyana‐Sundaram, Jey Jeyaseelan, François Potus, Sébastien Bonnet, Steeve Provencher   +10 more
doaj   +1 more source

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 7, October 2026.
Exercise activates skeletal muscle to release myokines (irisin, acute IL‐6, IL‐15 and BAIBA) and suppress myostatin, which may help counteract T2DM‐induced hyperglycemia, AGE accumulation, chronic inflammation and osteoimmune imbalance, potentially contributing to improved bone quality and reduced fracture risk.
Chao Wu, Jun Zou, Yu Yuan
wiley   +1 more source

Denosumab Versus Zoledronic Acid for Muscle Strength and Physical Performance in Postmenopausal Osteoporosis: A 3‐Year Prospective Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Osteoporosis and sarcopenia frequently coexist in older adults, yet whether denosumab provides muscle‐related benefits beyond bone remains uncertain. We compared denosumab and zoledronic acid across functional, imaging, biologic and study‐defined sarcopenia outcomes based on an Asian Working Group for Sarcopenia (AWGS) 2025‐informed
Xiangwen Li, Zineng Yuan, Nina Ma, Bijuan Huang, Hongyue Tao, Shuang Chen   +5 more
wiley   +1 more source

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Aging Cell, Volume 25, Issue 10, October 2026.
Our studies for the first time underscore the feasibility of long‐term SIRT6 activation as a pharmacological strategy to maintain the health of the intervertebral disc in the aging spine. ABSTRACT Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain.
Pranay Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah E. Bell, Mallory Toci, Olivia Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud   +11 more
wiley   +1 more source

Influence of lactate on the active force produced in skinned psoas and soleus muscle fibers from female rabbits

Physiological Reports, Volume 14, Issue 19, October 2026.
Abstract Lactate has been recognized as an energy source, suggesting its potential use as an ergogenic supplement. However, its effect on muscle contraction remains unclear. This study examined the effect of lactate on muscle active force using skinned fibers.
Shiho Kunimatsu, Atsuki Fukutani, Tadao Isaka   +2 more
wiley   +1 more source