Results 31 to 40 of about 6,859 (161)

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Characterization of a Rat C₆ Glioma‐Secreted Follistatin‐Related Protein (FRP) [PDF]

European Journal of Biochemistry, 1994
A protein was isolated from rat C6 glioma‐conditioned medium and was biochemically characterized. The heparin‐binding protein has a native molecular mass of 55–75000Da, a molecular mass of 40–48000 Da under denaturing conditions, and a pI of 5.0–6.0. Based on the determined partial amino acid sequences, the full lenght cDNA encoding the rat and human ...
Zwijsen, An, Blockx, Herman, Van Arnhem, Wouter, Willems, Jean, Fransen, Lucie, Devos, Kathleen, Raymackers, Jos, Van de Voorde, André, Slegers, H.   +8 more
openaire   +3 more sources

Circulating organokines in coronary artery disease and metabolic syndrome: FABP4, adiponectin, irisin, FSTL1

Biomolecules & Biomedicine
Cardiovascular disorders are closely linked to metabolic syndrome and remain a leading cause of mortality worldwide, despite advances in early detection and treatment.
Meltem Uyaner Kan, İbrahim Kilinc, Hakan Akilli, Hasan Huseyin Bilgic   +3 more
doaj   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Association between follistatin-related protein 1 and the functional status of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

Chinese Medical Journal, 2021
Abstract Background: Follistatin-like 1 (FSTL1) plays both pro-inflammatory and anti-inflammatory roles in the inflammatory processes. We investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV)-specific indices ...
Taejun Yoon, Sung Soo Ahn, Jung Yoon Pyo, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee, Li-Shao Guo   +6 more
openaire   +4 more sources

Identification of ActivinβA and Gonadotropin Regulation of the Activin System in the Ovary of Chinese Sturgeon Acipenser sinensis

Animals
Activin is a dimeric growth factor with diverse biological activities in vertebrates. This study aimed to investigate the regulatory role of the activin signaling pathway in the ovary of the endangered, cultured sturgeon species Acipenser sinensis.
Huamei Yue, Huan Ye, Rui Ruan, Hao Du, Chuangju Li   +4 more
doaj   +1 more source

Molecular Characterization of the Follistatin (FST) Gene in Quail and its Modulation through Natural Agonists [PDF]

Brazilian Journal of Poultry Science
Follistatin (FST) is a cysteine-rich monomeric protein capable of binding and neutralizing the action of several members of the transforming growth factor-beta (TGFβ) family, such as myostatin and activin, by binding to their receptors.
UlF Hassan, S Aftab, MS Rehman, S Arif, M Safdar, S Ahmed, K Ahmad, AD Cerbo, MM Azzam, M Alagawany   +9 more
doaj   +1 more source

Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV‐induced skin damage

Photochemistry and Photobiology, Volume 101, Issue 2, Page 338-349, March/April 2025.
In the present work with mouse models, we demonstrate that a novel compound, NEO400, is able to profoundly protect skin against damage caused by UV radiation (UVR) when it is applied to skin post‐UVR exposure. In comparison, Aloe vera or linoleic acid are unable to achieve a similar level of protection.
Stephen Swenson, Catalina Silva‐Hirschberg, Liliana Freeland, Kristen L. Chen, Nagore I. Marín‐Ramos, Axel H. Schönthal, Thomas C. Chen   +6 more
wiley   +1 more source

Ameliorative effects of follistatin‐related protein/TSC‐36/FSTL1 on joint inflammation in a mouse model of arthritis [PDF]

Arthritis & Rheumatism, 2004
AbstractObjectiveTo clarify the in vivo function of follistatin‐related protein (FRP)/TSC‐36/FSTL1 in rheumatoid arthritis (RA), we investigated the roles of FRP in a mouse model of arthritis.MethodsArthritis was induced in BALB/c mice by injecting anti–type II collagen monoclonal antibody and lipopolysaccharide.
Daisuke, Kawabata, Masao, Tanaka, Takao, Fujii, Hisanori, Umehara, Yoshimasa, Fujita, Hajime, Yoshifuji, Tsuneyo, Mimori, Shoichi, Ozaki   +7 more
openaire   +2 more sources

Physiological roles of activins in the human ovary

Journal of Bio-X Research, 2018
. Initially discovered in the pituitary as stimulators of follicle stimulating hormone, activins are homo- or heterodimers of inhibin subunits, which belong to the transforming growth factor-β superfamily.
Hsun-Ming Chang, Peter C.K. Leung
doaj   +1 more source