Results 31 to 40 of about 12,023,937 (197)

AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease

BMC Cancer, 2008
Background The incidence and mortality of hepatocellular cancer (HCC) complicating alcoholic and non-alcoholic fatty liver diseases (ALD and NAFLD) is rising in western societies.
Trerotoli Paolo, Day Christopher, Hudson Mark, Stewart Stephen, Gray Joe, Chattopadhyay Dipankar, Beale Gary, Giannelli Gianluigi, Manas Derek, Reeves Helen   +9 more
doaj   +1 more source

The Myostatin Propeptide and the Follistatin-related Gene Are Inhibitory Binding Proteins of Myostatin in Normal Serum [PDF]

Journal of Biological Chemistry, 2002
Myostatin, also known as growth and differentiation factor 8, is a member of the transforming growth factor beta superfamily that negatively regulates skeletal muscle mass (1). Recent experiments have shown that myostatin activity is detected in serum by a reporter gene assay only after activation by acid, suggesting that native myostatin circulates as
Jennifer J, Hill, Monique V, Davies, Adele A, Pearson, Jack H, Wang, Rodney M, Hewick, Neil M, Wolfman, Yongchang, Qiu   +6 more
openaire   +2 more sources

Heparin-mediated dimerization of follistatin [PDF]

, 2020
Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-β (TGFβ) family ligand antagonist ...
Kattamuri, Chandramohan, Thompson, Thomas B, Goebel, Erich J., Goebel, Erich J, Zhang, Fuming, Linhardt, Robert J, Tainer, John A, Walker, Ryan G., Linhardt, Robert J., Hammel, Michal, Walker, Ryan G, Tainer, John A., Thompson, Thomas B., Fuming Zhang, Erich J Goebel, John A Tainer, Robert J Linhardt, Thomas B Thompson, Chandramohan Kattamuri, Ryan G Walker, Michal Hammel   +20 more
core   +1 more source

Activins and related proteins in the establishment of pregnancy

, 2010
Activin A and related proteins (inhibins, follistatin [FS], follistatin-related gene [FLRG], endometrial bleeding associated factors [ebaf]) are involved in the complex mechanisms allowing the establishment and the maintenance of pregnancy.
FLORIO, P., PINZAUTI, S., REIS, F. M., LITTA, P., BONACCORSI, L., RAGO, G., PETRAGLIA, F., BORGES, L. E., BOY TORRES, P., GABBANINI, M.   +9 more
core   +2 more sources

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

Frontiers in Physiology, 2018
The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells.
Vincent F. M. Segers, Vincent F. M. Segers, Dirk L. Brutsaert, Dirk L. Brutsaert, Gilles W. De Keulenaer, Gilles W. De Keulenaer   +5 more
doaj   +1 more source

cDNA Cloning and Distribution of theXenopusFollistatin-Related Protein

Biochemical and Biophysical Research Communications, 1999
Recently, several proteins which have a follistatin module have been isolated. One of them, the follistatin-related protein (FRP), is encoded by TSC-36 (TGF-beta-stimulated clone 36) in mouse, originally isolated as a cDNA clone up-regulated by TGF-beta1 in mouse osteogenic MC3T3E1 cells.
K, Okabayashi, H, Shoji, Y, Onuma, T, Nakamura, K, Nose, H, Sugino, M, Asashima   +6 more
openaire   +2 more sources

Liver Endothelia Orchestrate MASH-Associated Macrophage Zonation Through FSTL1-ITGA4 Axis. [PDF]

Adv Sci (Weinh)
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Sun L, Yue Z, Fang Z, Xu H, Du W, Ling Y, Liu J, Song P, He F, Duan J, Wang L.   +10 more
europepmc   +2 more sources

Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling [PDF]

, 2013
Regeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not.
Wenemoser, Danielle, Reddien, Peter, Michael A Gaviño, Gavino, Michael A., Wang, Irving E., Irving E Wang, Peter W Reddien, Danielle Wenemoser   +7 more
core   +1 more source

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis [PDF]

, 2011
Follistatin-like 1 (Fstl1) is a secreted protein of the BMP inhibitor class. During development, expression of Fstl1 is already found in cleavage stage embryos and becomes gradually restricted to mesenchymal elements of most organs during subsequent ...
Moorman, A.F.M., Vivian S. W. Li, van den Hoff, M.J.B., Maurice J B van den Hoff, Johan H van Es, van den Hoff Maurice J. B., Li, V.S.W., Koolstra Jan Harm, Li Vivian S. W., Maurice J. B. van den Hoff, van Es, J.H., van der Velden Saskia, Hoff van den, M. J., Es van, J.H., Anita A A Buffing, Quinn Gunst, Johan H. van Es, Velden van der, S., Koolstra, J.H., Saskia van der Velden, Buffing, A.A.A., van den Born, M., Sylva, M., van Es Johan H., Koolstra, J. H., Jan Harm Koolstra, van den Born Maaike, Hans Clevers, Moorman, A. F., Antoon F. M. Moorman, Buffing Anita A. A., Clevers, H., Gunst Quinn, Li, V.S., Moorman Antoon F. M., Sylva Marc, Clevers Hans, Vivian S W Li, Marc Sylva, Buffing, A. A., Antoon F M Moorman, Gunst, Q., Maaike van den Born, Anita A. A. Buffing, van der Velden, S., Born van den, M.M.W.   +45 more
core   +2 more sources

Inhibin, activin and follistatin in the human placenta: a new family of regulatory proteins

, 1997
The family of inhibin-related proteins has been investigated extensively in the last decade. It is composed of three members: inhibin, activin and follistatin.
PETRAGLIA, FELICE, Petraglia, F.
core   +1 more source