Results 21 to 30 of about 12,023,937 (197)

The Adipose-Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte-Derived Neurotrophic Factor for WAT Browning. [PDF]

Adv Sci (Weinh)
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Jia XW, Liu JX, Wang RP, Wu XQ, Che Y, Wu MC, Shang HW, Lu X, Lu T, Wang LL, Jiang CY, Fang DL, Yang C, Gao Y.   +13 more
europepmc   +2 more sources

Myostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy [PDF]

, 2023
Myostatin is a myokine which acts upon skeletal muscle to inhibit growth and regeneration. Myostatin is endogenously antagonised by follistatin. This study assessed serum myostatin and follistatin concentrations as monitoring or prognostic biomarkers in ...
Mori-Yoshimura, Madoka, Jones, Kristi J, Diaz-Manera, Jordi, Stojkovic, Tanya, Mayhew, Anna, Day, John W., Wilson, Ian, Carlier, Pierre G, Fernández-Simón, Esther, Cox, Dan, Bravver, Elena, Fernández Simón, Esther, Bharucha-Goebel, Diana X., Mayhew, Anna G., Walter, Maggie C., Jones, Kristi J., Blamire, Andrew, Pestronk, Alan, Carlier, Pierre G., Mendell, Jerry R, Rufibach, Laura, Salort-Campana, Emmanuelle, Bushby, Kate, Mendell, Jerry R., Rufibach, Laura E., Day, John W, Paradas, Carmen, Schiava, Marianela, Straub, Volker, Walter, Maggie C, The Jain COS Consortium, Bharucha-Goebel, Diana X, James, Meredith K., Pegoraro, Elena, Moore, Ursula, Gordish-Dressman, Heather, Universitat Autònoma de Barcelona, James, Meredith K, Guglieri, Michela, Bharucha-Goebel, Diana, et al.,, Anna Mayhew, Kate Bushby, Ursula Moore, Andrew Blamire, Diana X. Bharucha-Goebel, Marianela Schiava, Jordi Diaz-Manera, Madoka Mori-Yoshimura, Ian Wilson, Meredith K. James, Heather Gordish-Dressman, Carmen Paradas, Maggie C. Walter, Volker Straub, Michela Guglieri, Pierre G. Carlier, Alan Pestronk, Tanya Stojkovic, Laura Rufibach, Jerry R. Mendell, Kristi J. Jones, Elena Pegoraro, Esther Fernández-Simón, Dan Cox, Emmanuelle Salort-Campana, John W. Day, Elena Bravver   +67 more
core   +3 more sources

Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

Frontiers in Endocrinology, 2022
Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular diseases.
Yakun Ren, Hao Zhao, Chunyan Yin, Xi Lan, Xi Lan, Litao Wu, Litao Wu, Xiaojuan Du, Xiaojuan Du, Helen R. Griffiths, Dan Gao, Dan Gao   +11 more
doaj   +1 more source

Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice

Cells, 2022
Follistatin (FST) as a gonadal protein is central to the establishment and maintenance of pregnancy. Trophoblasts’ migration and invasion into the endometrium are critical events in placental development.
Jing Li, Yan Qi, Ke Yang, Linjing Zhu, Xueling Cui, Zhonghui Liu   +5 more
doaj   +1 more source

The role of exercise-induced myokines in promoting angiogenesis

Frontiers in Physiology, 2022
Ischemic diseases are a major cause of mortality or disability in the clinic. Surgical or medical treatment often has poor effect on patients with tissue and organ ischemia caused by diffuse stenoses.
Chao Qi, Xianjing Song, He Wang, Youyou Yan, Bin Liu   +4 more
doaj   +1 more source

Follistatin as potential therapeutic target in prostate cancer [PDF]

, 2013
Follistatin is a single-chain glycosylated protein whose primary function consists in binding and neutralizing some members of the transforming growth factor-β superfamily such as activin and bone morphogenic proteins.
GIAMMANCO, Marco, Sepporta, MV, FLANDINA, Carla, TUMMINELLO, Francesca Maria, CRESCIMANNO, Marilena, DI MAJO, Danila, LETO, Gaetano, LA GUARDIA, Maurizio   +7 more
core   +1 more source

Identification of potential biomarkers related to mesenchymal stem cell response in patients with Alzheimer’s disease

Stem Cell Research & Therapy, 2023
Background Preclinical studies showed that mesenchymal stem cells (MSCs) ameliorate tau phosphorylation, amyloid-beta accumulation, and inflammation in Alzheimer’s disease (AD) mouse models via secretion of neurotrophic factors and cytokines. We aimed to
Yejoo Choi, Sungho Shin, Hyo Jin Son, Na-Hee Lee, Su Hyeon Myeong, Cheolju Lee, Hyemin Jang, Soo Jin Choi, Hee Jin Kim, Duk L. Na   +9 more
doaj   +1 more source

Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication between these different cell types, also called paracrine signaling, is essential for normal cardiac ...
Vincent F. M. Segers, Gilles W. De Keulenaer   +1 more
doaj   +1 more source

miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1 [PDF]

International Journal of Molecular Sciences, 2021
Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as key regulators in EMT processes; however, the mechanisms by which miRNAs target epicardial EMT remain largely unknown.
Elena Pontemezzo, Eleonora Foglio, Enza Vernucci, Alessandra Magenta, Marco D’Agostino, Sara Sileno, Elena Astanina, Federico Bussolino, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana   +11 more
openaire   +3 more sources

Follistatin-like 1 Prevents Renal Ischemia-Reperfusion Injury by Inhibition of Apoptosis via Upregulating AMPK/PPAR-δ Pathway.pdf

, 2023
The above image is derived from the original image of western blots in the article ‘Follistatin-like 1 Prevents Renal Ischemia-Reperfusion Injury by Inhibition of Apoptosis via Upregulating AMPK/PPAR-δ Pathway’.
Ken Chen (14586665)
core   +1 more source