Results 21 to 30 of about 867,229 (232)

Characterization of Insulin-like Peptide (ILP) and Its Potential Role in Ovarian Development of the Cuttlefish Sepiella japonica

Current Issues in Molecular Biology, 2022
The insulin-like peptide (ILP) family is well known for regulating reproduction in invertebrates, while its role in mollusks remains largely unknown. In this study, we first isolated and characterized the ILP gene in the cuttlefish Sepiella japonica. The
Zhenming Lü, Chenghao Yao, Shijie Zhao, Yao Zhang, Li Gong, Bingjian Liu, Liqin Liu   +6 more
doaj   +1 more source

Baicalin attenuates LPS-induced alveolar type II epithelial cell A549 injury by attenuation of the FSTL1 signaling pathway via increasing miR-200b-3p expression

Innate Immunity, 2021
In China, baicalin is the main active component of Scutellaria baicalensis , which has been used in the treatment of inflammation-related diseases, such as inflammation-induced acute lung injury. However, its specific mechanism remains unclear.
Xin-ya Duan, Yang Sun, Zhu-fen Zhao, Yao-qing Shi, Xun-yan Ma, Li Tao, Ming-wei Liu   +6 more
doaj   +1 more source

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Frontiers in Endocrinology, 2021
Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases.
Shehla Pervin, Shehla Pervin, Srinivasa T. Reddy, Srinivasa T. Reddy, Rajan Singh, Rajan Singh, Rajan Singh   +6 more
doaj   +1 more source

Fractalkine Improves the Expression of Endometrium Receptivity-Related Genes and Proteins at Desferrioxamine-Induced Iron Deficiency in HEC-1A Cells

International Journal of Molecular Sciences, 2023
Fractalkine (CX3CL1/FKN) is a unique chemokine belonging to the CX3C chemokine subclass. FKN exists in two forms: a membrane-bound form expressed by both endometrium cells and trophoblasts thought to be implicated in maternal–fetal interaction and a ...
E. Pandur, R. Pap, Gergely Jánosa, A. Horváth, K. Sipos   +4 more
semanticscholar   +1 more source

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

Scientific Reports, 2021
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity.
Ellen F. Mosleth, Christian Alexander Vedeler, Kristian Hovde Liland, Anette McLeod, Gerd Haga Bringeland, Liesbeth Kroondijk, Frode Steingrimsen Berven, Artem Lysenko, Christopher J. Rawlings, Karim El-Hajj Eid, Jill Anette Opsahl, Bjørn Tore Gjertsen, Kjell-Morten Myhr, Sonia Gavasso   +13 more
doaj   +1 more source

miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1 [PDF]

International Journal of Molecular Sciences, 2021
Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as key regulators in EMT processes; however, the mechanisms by which miRNAs target epicardial EMT remain largely unknown.
Elena Pontemezzo, Eleonora Foglio, Enza Vernucci, Alessandra Magenta, Marco D’Agostino, Sara Sileno, Elena Astanina, Federico Bussolino, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana   +11 more
openaire   +3 more sources

Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma

BMC Medicine, 2023
Background Multiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with causal genetic evidence offers a chance to uncover novel therapeutic targets.
Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu, Jian Hou   +4 more
doaj   +1 more source

Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

Frontiers in Endocrinology, 2022
Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular diseases.
Yakun Ren, Hao Zhao, Chunyan Yin, Xi Lan, Xi Lan, Litao Wu, Litao Wu, Xiaojuan Du, Xiaojuan Du, Helen R. Griffiths, Dan Gao, Dan Gao   +11 more
doaj   +1 more source

Serum Concentrations of Myostatin and Myostatin-Interacting Proteins do not differ between young and Scarcopenic elderly men [PDF]

, 2011
Peer ...
A. DeVries, A. Joyson, A. M. Tommasi, A. Ratkevicius, Amin, Baumgartner, C. A. Greig, C. Grierson, Carlson, Clark, D. Crowther, D. M. Reid, F. Gilbert, Gonzalez-Cadavid, GREIG, H. Wackerhage, Hameed, I. Selmer, J. Brady, K. C. H. Fearon, Lakshman, Lauretani, Lee, Lexell, Moreland, Newman, P. Rauchhaus, P. Yaworsky, Pahor, Payette, Rantanen, Rommel, Rosenberg, S. Alesci, Schuelke, Siriett, Streckis, T. Dhanani, T. W. Redpath, Wagner, Wolfe, Zimmers   +41 more
core   +1 more source

Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

Frontiers in Physiology, 2020
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic and complex endocrine organ, which produces and secretes several adipokines, including hormones, cytokines, extracellular matrix (ECM) proteins, and growth and ...
Lucia Recinella, Giustino Orlando, Claudio Ferrante, Annalisa Chiavaroli, Luigi Brunetti, Sheila Leone   +5 more
doaj   +1 more source