Results 21 to 30 of about 6,859 (161)

The role of exercise-induced myokines in promoting angiogenesis

Frontiers in Physiology, 2022
Ischemic diseases are a major cause of mortality or disability in the clinic. Surgical or medical treatment often has poor effect on patients with tissue and organ ischemia caused by diffuse stenoses.
Chao Qi, Xianjing Song, He Wang, Youyou Yan, Bin Liu   +4 more
doaj   +1 more source

Identification of potential biomarkers related to mesenchymal stem cell response in patients with Alzheimer’s disease

Stem Cell Research & Therapy, 2023
Background Preclinical studies showed that mesenchymal stem cells (MSCs) ameliorate tau phosphorylation, amyloid-beta accumulation, and inflammation in Alzheimer’s disease (AD) mouse models via secretion of neurotrophic factors and cytokines. We aimed to
Yejoo Choi, Sungho Shin, Hyo Jin Son, Na-Hee Lee, Su Hyeon Myeong, Cheolju Lee, Hyemin Jang, Soo Jin Choi, Hee Jin Kim, Duk L. Na   +9 more
doaj   +1 more source

Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication between these different cell types, also called paracrine signaling, is essential for normal cardiac ...
Vincent F. M. Segers, Gilles W. De Keulenaer   +1 more
doaj   +1 more source

miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1 [PDF]

International Journal of Molecular Sciences, 2021
Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as key regulators in EMT processes; however, the mechanisms by which miRNAs target epicardial EMT remain largely unknown.
Elena Pontemezzo, Eleonora Foglio, Enza Vernucci, Alessandra Magenta, Marco D’Agostino, Sara Sileno, Elena Astanina, Federico Bussolino, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana   +11 more
openaire   +3 more sources

AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease

BMC Cancer, 2008
Background The incidence and mortality of hepatocellular cancer (HCC) complicating alcoholic and non-alcoholic fatty liver diseases (ALD and NAFLD) is rising in western societies.
Trerotoli Paolo, Day Christopher, Hudson Mark, Stewart Stephen, Gray Joe, Chattopadhyay Dipankar, Beale Gary, Giannelli Gianluigi, Manas Derek, Reeves Helen   +9 more
doaj   +1 more source

The Myostatin Propeptide and the Follistatin-related Gene Are Inhibitory Binding Proteins of Myostatin in Normal Serum [PDF]

Journal of Biological Chemistry, 2002
Myostatin, also known as growth and differentiation factor 8, is a member of the transforming growth factor beta superfamily that negatively regulates skeletal muscle mass (1). Recent experiments have shown that myostatin activity is detected in serum by a reporter gene assay only after activation by acid, suggesting that native myostatin circulates as
Jennifer J, Hill, Monique V, Davies, Adele A, Pearson, Jack H, Wang, Rodney M, Hewick, Neil M, Wolfman, Yongchang, Qiu   +6 more
openaire   +2 more sources

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

Frontiers in Physiology, 2018
The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells.
Vincent F. M. Segers, Vincent F. M. Segers, Dirk L. Brutsaert, Dirk L. Brutsaert, Gilles W. De Keulenaer, Gilles W. De Keulenaer   +5 more
doaj   +1 more source

The Non-Linear Profile of Aging: U-Shaped Expression of Myostatin, Follistatin and Intermediate Signals in a Longitudinal In Vitro Murine Cell Sarcopenia Model

Proteomes
Sarcopenia is linked to the decline in muscle mass, strength and function during aging. It affects the quality and life expectancy and can lead to dependence.
Janire Alonso-Puyo, Oihane Izagirre-Fernandez, Olatz Crende, Jesús Seco-Calvo, Ainhoa Fernandez-Atutxa, Diego Fernandez-Lazaro, Patricia Garcia-Gallastegi, Begoña Sanz   +7 more
doaj   +1 more source

The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair [PDF]

Journal of Endocrinology, 2001
Follistatin is a secreted protein that binds activin in vitro and in vivo and thereby inhibits its biological functions. Recently, related human and murine genes, designated follistatin-related gene (FLRG), were identified, and their products were shown to bind activin with high affinity.
Wankell M, Kaesler S, Zhang YQ, Florence C, Werner S, Duan R   +5 more
openaire   +3 more sources

Activin signaling as an emerging target for therapeutic interventions

Cell Communication and Signaling, 2009
After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activities including the regulation of gonadal ...
Ageta Hiroshi, Sunada Yoshihide, Uezumi Akiyoshi, Hitachi Keisuke, Nakatani Masashi, Tsuchida Kunihiro, Inokuchi Kaoru   +6 more
doaj   +1 more source