Results 121 to 130 of about 23,920,837 (347)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Journal of Clinical MicrobiologyCore-genome multi-locus sequence typing (cgMLST) is a well-established and standardized method for genomics-based cluster detection and phylogenomic analysis of bacteria.
Bert Bogaerts +9 more
doaj +1 more source
Hunt for the Supertwister [PDF]
In this activity students try to identify the best time of year and place to position spotters to see possible tornado outbreaks. In order to do so they study a graphic that depicts the mean number of days per century with at least one F2 or greater ...
WGBH Educational Outreach Staff
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Knowledge, Attitudes, and PrEP Prescribing Practices of Health Care Providers in Philadelphia, PA
Journal of Primary Care & Community Health, 2019 Introduction: Preexposure prophylaxis (PrEP) is an effective biomedical intervention that has the potential to dramatically decrease the incidence of HIV but remains an underutilized method of HIV prevention.
Margaret R. Carter +3 more
doaj +1 more source
This lesson provides an introduction to the world oil market and the United States' dependence on it. Topics include our current usage, sources, and the political implications of acquiring oil from an international market. There is also discussion of how
John Pratte
core
Actively Teaching Active Teaching Techniques
Journal of education & teaching in emergency medicineThe target audience for this small group workshop are interns and residents of any specialty.All residents are expected to become proficient teachers in a variety of settings as they progress in training, and many residency programs offer advanced training or credentialing in medical education.1,2 Recently, some emergency medicine programs have also ...
Walz, MD, Alice, Kane, MD, Ian
openaire +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Toxic Chemicals (title provided or enhanced by cataloger) [PDF]
This lesson introduces students to the concept of toxic chemicals. Topics include a definition of the term 'toxic', factors that can affect the potential for a chemical to be harmful, and a brief overview of federal agencies that have authority to ...
Chris Fox
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source