Results 121 to 130 of about 14,969,879 (299)
Central to good science are accurate observations, testable hypotheses, well-designed experiments or other tests, and reasonable data analyses. The purpose of this activity is to introduce the basics of designing and analyzing experiments.
Matthew Laposata
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Technology Teacher: Navigating by Good Gyrations [PDF]
, 2002 This activity describes some simple, yet impressive gyroscopic demonstrations using only a bike wheel with a quick-release hub. Then, itIt explains both the angular momentum principle that tends to keep the wheel in a rigid plane and the effects of the ...
NASA JPL
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The transport and transformation of substances in the environment are known collectively as biogeochemical cycles. These global cycles involve the circulation of elements and nutrients that sustain both the biological and physical aspects of the ...
John Pratte
core
Technology Teacher: Listening for Rings from Space [PDF]
, 2004 This activity introduces gravitational waves and the NASA technology being developed to detect them in space. It involves building a metaphorical interferometer that demonstrates how the mission (and all interferometry) works.
NASA JPL
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The N Terminus of ClpB from Thermus thermophilus Is Not Essential for the Chaperone Activity [PDF]
, 2002 Philipp Beinker +4 more
openalex +1 more source
Ground-Level Ozone: Smog City [PDF]
This lesson provides an introduction to the problems associated with ground-level ozone ('smog'). It reinforces the idea that ozone at ground level is harmful while that in the upper atmosphere has a beneficial effect.
Matt Laposata
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source