Results 281 to 290 of about 14,969,879 (299)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Association of Nature-Based (Satoyama) Activities and Multiple Health Outcomes Among Older Adults: A Pilot Study. [PDF]

Geriatr Gerontol Int
Lyu W, Tanaka T, Koshizuka M, Katagiri T, Hamada T, Kani K, Nishihara K, Yamamoto Y, Fukushi K, Iijima K.   +9 more
europepmc   +1 more source

Guild Activities [PDF]

, 1951
Catholic Physicians\u27 Guilds
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The effect of personalized forest therapy programs on stress and obsessive-compulsive symptoms in patients with depression. [PDF]

Front Public Health
Kim G, Kang S, Paek K, Seo Y, Park S, Choi H, Min G, Lee N, Park S, Choi S, Yeon P.   +10 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

New Method to Motivate Participation in Daily Life/Everyday Life Activities Using Sensor-Based Smart Application Translating Intention into Action (TIA). [PDF]

Sensors (Basel)
Freiesleben M, Ritterband-Rosenbaum A, Justiniano MD.   +2 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Physical activity preferences across demographic groups: a systematic review of population-based evidence and implications for public health and intervention design. [PDF]

Front Public Health
Martín-Martínez C, García-González M, Mijarra-Murillo JJ, Delfa-de-la-Morena JM.   +3 more
europepmc   +1 more source

Physical activity types, variety, and mortality: results from two prospective cohort studies. [PDF]

BMJ Med
Han H, Hu J, Lee DH, Zhang Y, Giovannucci E, Stampfer MJ, Hu FB, Hu Y, Sun Q.   +8 more
europepmc   +1 more source