Results 141 to 150 of about 2,034,059 (380)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry

open access: yesJournal of Dermatological Treatment
Background: Little is known about the extent of impairments in work and activities of daily life (ADL) in patients with psoriasis, and the influence of contextual factors such as disease-related characteristics and treatment.
Tamara W. van Hal   +26 more
doaj   +1 more source

Assessment of functional capacity in patients attending geriatrics outpatient department at Civil Hospital, Ahmedabad

open access: yesCHRISMED Journal of Health and Research, 2016
Aims: To access the quality of life in terms of functional capacity and to estimate the prevalence of depression among geriatric patients. Settings and Design: A hospital-based study was conducted in Civil Hospital, Ahmedabad between July and September ...
Neeta Mathur
doaj   +1 more source

Factors associated with basic and instrumental activities of daily living in elderly participants of a population-based survey: the Nord-Trøndelag Health Study, Norway

open access: yesBMJ Open, 2018
Objectives To investigate factors associated with the need for assistance in basic and instrumental activities of daily living in Norwegian elderly. Design Prospective cohort study. Setting The Nord-Trøndelag Health Study (HUNT), a large population-based
Siri H Storeng, E. Sund, S. Krokstad
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The Effect of Medical Check-up and Basic Physical Activities Daily Living: Panel Study on Among Indoesian Elderly 1993-2000 [PDF]

open access: yes, 2007
In the 21st Century, Indonesia becomes the fourth biggest ageing country in the World as reported by the Second World Assembly on Ageing (2002). The Indonesian Household Health Survey (2001) reported 88,9% of the elderly suffered from disability ...
Trihandini, I. (Indang)
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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