Results 71 to 80 of about 12,118,149 (309)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Association of life-space mobility with physical and depressive status in older hemodialysis patients: the REPnet-HD study

Renal Replacement Therapy
Introduction Low physical function and depressive symptoms are frequent in older patients undergoing hemodialysis. This study aimed to investigate the association between life-space mobility (LSM), low physical function, and depressive symptoms in older ...
Sho Kojima, Naoto Usui, Yuki Nishiyama, Nobuhito Shinozaki, Nobuyuki Shirai, Kenta Mikami, Yoichi Sato, Takahumi Noji, Izumi Noda, Yoshifumi Abe, Masakazu Saitoh   +10 more
doaj   +1 more source

The ManUp Study : physical activity interventions for middle-aged men : a review of what does and does not work

, 2011
Physical inactivity is one of the main modifiable risk factors for a range of noncommunicable diseases. Of particular interest are middle-aged men, a hard-to-reach population group for health interventions.
Duncan, Mitch J., George, Emma S. (R17418), Kolt, Gregory S. (R11602), Vandelanotte, Corneel, Caperchione, Cristina M., Mummery, Kerry   +5 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The impact of long-term isolation on anxiety, depressive-like and social behavior in aging Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) male rats

Scientific Reports
Aging is a complex process associated with multimorbidity. Hypertension, one of widespread states, is among main causes of age-related alterations in behavior, emotionality and sociability. We studied the effects of long-term isolated housing on anxiety,
Diana I. Mamedova, Olga A. Nedogreeva, Anna O. Manolova, Viktoria O. Ovchinnikova, Pavel A. Kostryukov, Natalia A. Lazareva, Yulia V. Moiseeva, Liya V. Tret’yakova, Alexey A. Kvichansky, Mikhail V. Onufriev, Victor A. Aniol, Margarita R. Novikova, Natalia V. Gulyaeva, Mikhail Yu. Stepanichev   +13 more
doaj   +1 more source

QUALITY OF LIFE, PERCEIVED STIGMA, ACTIVITY AND PARTICIPATION OF PEOPLE WITH LEPROSY-RELATED DISABILITIES IN SOUTH-EAST NEPAL

Disability, CBR and Inclusive Development, 2011
In Nepal, many people live with leprosy-related disabilities. The objective of this study was to evaluate differences in socio-economic characteristics, quality of life (QOL), perceived stigma, activity and participation among people affected by leprosy ...
Huib Cornielje, Wim van Brakel, Corline Brouwers   +2 more
doaj   +1 more source

Associations between quality of life, physical activity, and sedentary behaviour : an examination of continuous and bout measures of activity and sedentary behaviour from the Walk 2.0 trial

, 2015
Objective: The health benefits of physical activity participation and minimising sedentary behaviours are well known. As well, evidence exists for the relationship between physical activity and health-related quality of life.
Duncan, Mitch J., Maeder, Anthony (R13343), George, Emma S. (R17418), Rebar, Amanda L., Rosenkranz, Richard R., Kolt, Gregory S. (R11602), Vandelanotte, Corneel, Caperchione, Cristina M.   +7 more
core  

Activity - Binary Code [PDF]

, 2019
A Binary Code activity and worksheet for CS0 students.
Domanski, Robert J
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Examining what men really want when it comes to promoting physical activity and nutrition using information technology : findings from the ManUp Study

, 2011
Promoting a healthy lifestyle to middle-aged men has its challenges, and as such, requires novel, pragmatic, and accessible approaches. The purpose of this study was to examine the perceptions of middle-aged men living in a rural/regional environment ...
Duncan, Mitch J., Ellison, Marcus, George, Emma S. (R17418), Kolt, Gregory S. (R11602), Vandelanotte, Corneel, Caperchione, Cristina M., Mummery, Kerry   +6 more
core