Results 121 to 130 of about 18,606,965 (308)

Introduction of Research Master Students in the Problems of the Organization of Learning Activities in the Secondary School (Based on the Natural Sciences)

Психологическая наука и образование, 2015
The article focuses on the designing of disciplines, based on the competence and activity approach to the content and methods of training of future teachers in the research psycho-pedagogical master’s program. Particular attention is paid to the creation
Guruzhapov V. A, Sanina S. P.
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An Activity-Based Sensing Approach to Multiplex Mapping of Labile Copper Pools by Stimulated Raman Scattering [PDF]

Molecular imaging with analyte-responsive probes offers a powerful chemical approach to study biological processes. The most common types of reagents for bioimaging employ a fluorescence readout, but the relatively broad emission bands of this modality ...
Miku, Oi, Martina, Ralle, Yishu, Jiang, Laura , Torrente, Gina, DeNicola, Wei, Min, Sophia, Miller, Aidan T. , Pezacki, Christopher, Chang, Elsy El , Khoury, Naixin , Qian   +10 more
core   +2 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

A human-computer interactive approach based on activity-section analysis for BPR

, 2000
In any business process reengineering (BPR) project, a thorough understanding of various tasks and activities of the organization is required. Very often this idea is captured using a simple flow chart or static representation diagram.
Fung, RYK, Ip, M.H., Fung, R.Y.K., Wang DW(汪定伟), Wang, D, Ip, WH, Zhiwen Tang, Tang, Z   +7 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A mathematical programming approach for supplier selection using Activity Based Costing. [PDF]

Vendor selection is an important problem in today's competitive environment . Decisions involve the selection of vendors and the determination of order quantities to be placed with the selected vendors.
Degraeve, Zeger, Roodhooft, Filip
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Vendor selection and evaluation : an activity based costing appoach. [PDF]

In this paper we propose an Activity Based Costing approach for vendor selection and evaluation. This system allows us to compute total costs caused by a supplier in a firm's production process, thereby increasing the objectivity in the selection process.
Konings, Joep, Roodhooft, Filip
core