Results 121 to 130 of about 32,826,106 (343)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Культурно-историческая психология, 2016 The article represents a brief report on the work of the International Symposium: «Scientific School of L.S. Vygotsky: Traditions and Innovations» and VI th International ISCAR Summer University for PhD Students and young scholars, that were held in ...
Baykovskaya N.A., , Rubtsova O.V.,
doaj +1 more source
"Interstellar Wanderers:" Digital Support for Teaching Place Value Within the Activity Approach Framework. [PDF]
Psychol Russ, 2023 Vysotskaya E, Lobanova A.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Player agency in interactive narrative: audience, actor & author [PDF]
, 2007 The question motivating this review paper is, how can computer-based interactive narrative be used as a constructivist learn- ing activity? The paper proposes that player agency can be used to link interactive narrative to learner agency in ...
Hammond, S., Pain, H., Smith, Tim J.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Helping Students Master Concepts in Mechanics by Graphing with Spreadsheets [PDF]
, 2001 An example of a curricular activity to help students master concepts in mechanics is presented. Students measure positions and times of movements using calculators, and construct graphs using spreadsheets.
Restrepo, G. F.
core +1 more source
Active approach to hand osteoarthritis [PDF]
Rheumatology, 2015 Rikke H, Moe, Maura D, Iversen
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Activity Potential of the Category “Ignorance” in Epistemological Space of the Educational Paradigm
Высшее образование в России, 2019 Modern justifications of essential interrelation and interdependence between the concepts of “knowledge” and “ignorance” in many ways can contribute to theoretical, methodological, and practical specification of forms and means of pedagogical mediation ...
I. N. Charikova +2 more
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