Results 11 to 20 of about 6,345,889 (290)

Conditionally Activated (“Caged”) Oligonucleotides [PDF]

open access: yesMolecules, 2021
Conditionally activated (“caged”) oligonucleotides provide useful spatiotemporal control for studying dynamic biological processes, e.g., regulating in vivo gene expression or probing specific oligonucleotide targets. This review summarizes recent advances in caging strategies, which involve different stimuli in the activation step.
Linlin Yang, Ivan J. Dmochowski
openaire   +3 more sources

Electrochemical Cage Activation of Carboranes [PDF]

open access: yesAngewandte Chemie International Edition, 2022
Abstract Carboranes are boron–carbon molecular clusters that possess unique properties, such as their icosahedron geometry, high boron content, and delocalized three‐dimensional aromaticity. These features render carboranes valuable building blocks for applications in supramolecular design, nanomaterials, optoelectronics ...
Long Yang   +3 more
openaire   +3 more sources

Caging NLRP3 tames inflammasome activity [PDF]

open access: yesCell, 2021
How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.
Schroder, Kate, Coll, Rebecca C
openaire   +5 more sources

Chemotactic self-caging in active emulsions

open access: yesProceedings of the National Academy of Sciences, 2022
A common feature of biological self-organization is how active agents communicate with each other or their environment via chemical signaling. Such communications, mediated by self-generated chemical gradients, have consequences for both individual motility strategies and collective migration patterns.
Babak Vajdi Hokmabad   +4 more
openaire   +5 more sources

Active cage model of glassy dynamics [PDF]

open access: yesPhysical Review E, 2016
We build up a phenomenological picture in terms of the effective dynamics of a tracer confined in a cage experiencing random hops to capture somec haracteristics of glassy systems. This minimal description exhibits scale invariance properties for the small-displacement distribution that echo experimental observations.
Étienne Fodor   +3 more
openaire   +4 more sources

Controlling the Activity of a Caged Cobalt‐Porphyrin‐Catalyst in Cyclopropanation Reactions with Peripheral Cage Substituents [PDF]

open access: yesEuropean Journal of Inorganic Chemistry, 2021
AbstractIn this study, three novel cubic cages were synthesized and utilized to encapsulate a catalytically active cobalt(II) meso‐tetra(4‐pyridyl)porphyrin guest. The newly developed caged catalysts (Co‐G@Fe8(Zn‐L ⋅ 1)6, Co‐G@Fe8(Zn‐L ⋅ 2)6 and Co‐G@Fe8(Zn‐L ⋅ 3)6) can be easily synthesized and differ in exo‐functionalization, which are either none ...
Valentinos Mouarrawis   +3 more
openaire   +2 more sources

Cage activity in the Virginia opossum [PDF]

open access: yesPsychonomic Science, 1968
Cage activity of four Virginia opossums was measured twice daily (morning and night) under six levels of ambient illumination (dark, less than 1, 2.5, 5, 25, 50 ft-c). Analysis of variance indicated that the Ss were significantly more active under the three lower levels of illumination than under the three higher ones and were significantly more active
Donna M. Cone, A. L. Cone
openaire   +1 more source

Caged Activators of Artificial Allosteric Protein Biosensors

open access: yesACS Synthetic Biology, 2020
Abstract The ability of proteins to interconvert unrelated biochemical inputs and outputs underlays most energy and information processing in biology. A common conversion mechanism involves a conformational change of a protein receptor in response to a ligand binding or a covalent modification, leading to allosteric activity ...
Selvakumar Edwardraja   +7 more
openaire   +5 more sources

Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives

open access: yesMolecules, 2017
Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a–3h. The chemical structures of the synthesized compounds were elucidated by spectroscopic methods.
Ümide Demir Özkay   +3 more
doaj   +1 more source

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