Results 61 to 70 of about 376,807 (240)

Development of Activity of Daily Living Program for Parents with Autistic Children in Surabaya

Jurnal Penelitian dan Pengembangan Pendidikan Luar Biasa, 2017
The result of observation in some parents shows that there is no guidance used by parents in the implementation of self-study, washing hands, eating, and drinking, so that, it can inhibit parents in providing treatment for autistic children at home.
Dita Utami Febriani
doaj   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Health-related quality of life and activities of daily living of Thai elderly people in Pathumthani Social Welfare Development Center for Older Persons

Journal of Associated Medical Sciences, 2017
Background: Currently, Thailand is an ageing society. An increase of age related to changes of physical and physiology. These changes lead to body degradation that affects a health-related quality of life and activities of daily living.
Khemmapak Charoensuksiri, Siripich Charoensuksiri   +1 more
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The relationship between the Barthel Index and stroke-associated pneumonia in elderly patients and factors of SAP

BMC Geriatrics
Background Stroke-associated pneumonia (SAP) is a common complication in stroke patients, and the Barthel Index (BI) is a well-established metric for assessing activities of daily living (ADL).
Bin Wu, Haowen Luo, Jingyi Li, Yongsen Chen, Jianmo Liu, Pengfei Yu, Zhilang Yan, Aiqin Wang, Hongfei Xian, Jingyao Ke, Rui Cheng, Xiaoman Wang, Canwei Yi, Weijiang Han, Huiming Liao, Yifan Wu, Weijie Jia, Mengqi Han, Yingping Yi   +18 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Perbedaan Tingkat Activity of Daily Living (ADL) antara Lansia Aktif dengan Lansia Tidak Aktif Melakukan Kunjungan ke Posyandu Lansia di Kelurahan Tunggulwulung Kecamatan Lowokwaru

Professional Health Journal, 2020
Increasing one's age will be followed by various changes that will affect the physical and psychological conditions. The older is a person, the more his physical abilities will decline causing the elderly to become dependent on others, including in ...
surninenta surninenta
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Relationship between post-stroke functional recovery and quality of life among Nigerian stroke survivors

Nigerian Postgraduate Medical Journal, 2013
Aims and objectives: This study explored relationship between post-stroke functional recovery and QoL among Nigeria SSv with first-ever stroke. Patients, materials and methods: This Study involved 65 (33 males and 32 females) individuals diagnosed of ...
Gbiri, A Caleb, Akinpelu, O Aderonke
doaj