Results 51 to 60 of about 376,807 (240)

Bibliometric Analysis of Publications on the Level of Independence in Elderly Activity of Daily Living between 2000 and 2022

Babcock University Medical Journal
Background: This study aims to analyze the nursing literature and examine the extent of older people's independence in fulfilling daily living activities. Main body: A study was conducted with bibliometric analysis of research papers published between
Edy Soesanto, Arief Shofyan Baidhowy, Much Nurkharistna Al Jihad, Nittiya Noysipoom, Satriya Pranata   +4 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Verifying Properties of Activities of Daily Living

The monitoring of Activities of Daily Living (ADLs) for older adults can support their well-being since deviations in behaviour may indicate cognitive or physical decline, and reduced quality-of-life. In this work we present a new methodology that combines the spatial context with the observed behaviour of the person to enable a rigorous analysis of ...
Ricardo Contreras, Filip Smola, Jiawei Zheng, Jane Hillston, Jacques D. Fleuriot   +4 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Pattern of morbidity among elders attending general practice: health needs assessment of geriatric patients in Oman

Geriatric Care, 2018
The main purpose of this study was to identify specific problems and pattern of morbidities that is common in the elderly. A cross sectional study surveying the health status and needs of targeted population was conducted in selected primary health care (
Shaikh Muhammad Naeem, Firdous Jahan, Muhammad Asadullah Siddiqui, Muhammad Moazzam Khan   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Hubungan Antara Activity Of Daily Living Dengan Kejadian Depresi Pada Lanjut Usia

Citra Delima
Lanjut usia akan mengalami proses penuaan, pada proses ini akan mengalami akumulasi perubahan yang kompleks, terutama perubahan dalam kondisi fisik yang mana hal tersebut akan mempengaruhi kemampuan lansia dalam melakukan activity of daily living, lansia
Aliyah, Leya Indah Permatasari, Rizaluddin Akbar   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source