Results 71 to 80 of about 16,937,312 (352)

Three-dimensional spectral analysis of gravity waves from airglow observations over Northwest China

Earth and Planetary Physics
The three-dimensional spectral analysis method was applied to airglow data from September 2023 to August 2024 derived from an OH airglow imager located at the Hejing station (42.79°N, 83.73°E) to study the propagation characteristics of gravity waves ...
QinZeng Li, JiYao Xu, Wei Yuan, Xiao Liu, YaJun Zhu, WeiJun Liu   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ISNet: Decomposed Dynamic Spatio‐Temporal Neural Network for Ionospheric Scintillation Forecasts

Space Weather
Accurate prediction of ionospheric scintillation is essential for ensuring the reliability of spaceborne and ground‐based radio wave technology infrastructures, including but not limited to navigation and communication systems.
Zhixu Gao, Yanhong Chen, Xianzhi Ao, Fulu Yue, Hong Chen, Hao Deng, Bingxian Luo, Xin Wang, Tianjiao Yuan   +8 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Public Space: Activation v. De-Activation

New Instrumentalities, 2018
Historically, the great cities of the world have built public spaces that have often been used as venues for spectacle, and displays of power and status. These public venues are part of the identity of these cities and have an importance and influence far beyond their physical dimensions or geometric shapes.
Clifton C. Ellis, David J. Isern
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Flare Prediction Modeling Based on the Time Series of SHARP Parameters Along the Polarity Inversion Line of Active Regions

Space Weather
The polarity inversion line (PIL) in active regions (ARs) is considered to be closely associated with solar flare eruptions. In this study, we rigorously constructed standardized data sets based on time series of different lengths using Space‐weather HMI
Siwei Liu, Jingjing Wang, Andrzej Fludra, Robertus Erdélyi, Bingxian Luo, Tieyan Wang, Siqing Liu, Qiuzhen Zhong   +7 more
doaj   +1 more source

Long-Term Variations in Background Bias and Magnetic Field Noise in HSOS/SMFT Observations

Universe
The Solar Magnetic Field Telescope (SMFT) at Huairou Solar Observing Station (HSOS) has conducted continuous observations of solar vector magnetic fields for nearly four decades, and while the primary optical system remains unchanged, critical components—
Haiqing Xu, Hongqi Zhang, Suo Liu, Jiangtao Su, Yuanyong Deng, Shangbin Yang, Mei Zhang, Jiaben Lin   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source