Results 81 to 90 of about 4,049,670 (304)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Solar Origins of Short-Term Periodicities in Near-Earth Solar Wind and Interplanetary Magnetic Field

Applied Sciences
This study investigates the solar origins of short-term periodicities in the near-Earth solar wind and interplanetary magnetic field (IMF) using long-term observations (1995–2024) and Potential Field Source Surface modeling.
Huichao Li, Yunxi Zhang, Jinzhou Bao, Botian Tang, Jiangrong Xie, Kangyan Wang   +5 more
doaj   +1 more source

Spacecraft architecture [PDF]

Three requirements for a spacecraft interior are considered. Adequate motor activity in the anatomical-physiological sense results from attention to the anthropometric characteristics of humans.
Zefeld, V. V.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Review of recent observations of magnetic holes in the solar wind

Discover Space
Magnetic holes (MHs) are ubiquitous coherent structures within the solar wind, defined by localized depressions in the magnetic field. They are increasingly recognized as fundamental sites of energy conversion and particle energization, playing a crucial
C. Y. Li, Y. Wang, F. S. Wei, X. S. Feng, Z. K. Xu, Y. X. Lu, B. Y. Wang, P. B. Zuo, C. W. Jiang, X. J. Xu, Z. L. Zhou   +10 more
doaj   +1 more source

Spectrophotometric properties of Martian soil at the landing area of the Tianwen–1 Zhurong rover

Astronomy & Astrophysics
Context. The Navigation and Terrain Camera (NaTeCam) on board the Zhurong rover acquired extensive imaging data of the landing site under a wide range of phase angles, providing a unique opportunity to investigate the photometric properties of this area.
Zhou Xiang, Yang Yazhou, Wu Xing, Liu Yang, Wan Wenhui, Liu Bin, Liu Jia, Zou Yongliao   +7 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Measuring environmental exposures in people's activity space: The need to account for travel modes and exposure decay. [PDF]

J Expo Sci Environ Epidemiol, 2023
Wei L, Kwan MP, Vermeulen R, Helbich M.
europepmc   +2 more sources

The disrupted jet stream and its influence on flight time during solar proton events

Scientific Reports
The long-chain effects of eruptive solar activities on Earth’s magnetosphere, ionosphere, and the mid-to-lower atmospheric circulation are an important theoretical research topic in the fields of space weather and atmospheric science.
Xiaoheng Xu, Yi Wang, Fengsi Wei, Xueshang Feng, Manhui Bo, Hongwu Tang, Diansheng Wang, Lei Bian, Boyi Wang, Pingbing Zuo, Chaowei Jiang, Xiaojun Xu, Zilu Zhou, Zeng Li, Peng Zou, Yun Li, Liang Zeng, Xiaoxing Zhu   +17 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source