Results 101 to 110 of about 4,049,670 (304)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Evolution of Hot Flow Anomalies in Martian Space Environment

Geophysical Research Letters
Hot Flow Anomalies (HFAs) are transient foreshock structures generated by solar wind discontinuity‐bow shock interactions, with their evolution only confirmed near Earth.
Heying Wang, Mingyu Wu, Yangjun Chen, Qi Lv, Guoqiang Wang, Sudong Xiao, Peng E, Aimin Du, Ding Yuan, Tielong Zhang   +9 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Martian Ionospheric Cold Hydrogen Ion Escape at Solar Maximum: First Observations

The Astrophysical Journal
The water escape from Mars to space could be in the form of hydrogen and oxygen ions as driven by solar wind–Mars interactions. Although oxygen ion escape has been extensively investigated, the H ^+ escape rate was measured only at solar minimum.
Qi Xu, Lianghai Xie, Limin Wang, Fuhao Qiao, Lei Li, Yiteng Zhang, Wenya Li, Yongyong Feng, Jijie Ma, Jing Wang, Linggao Kong   +10 more
doaj   +1 more source

Research on Removing Thin Cloud Interference in Solar Flare Monitoring with SMAT-Configured Telescopes

Universe
The precise monitoring of solar flares holds significant scientific value for space mission safety, communication security, and space environment forecasting.
Hongyan Li, Shangbin Yang, Xing Hu, Haiqing Xu   +3 more
doaj   +1 more source

Scheduling Markovian PERT networks with maximum-NPV objective. [PDF]

We examine project scheduling with net-present-value objective and exponential activity durations, using a continuous-time Markov decision chain. Based on a judicious partitioning of the state space, we achieve a significant performance improvement ...
Creemers, Stefan, Lambrecht, Marc, Leus, Roel   +2 more
core  

Space activities in Glasgow; advanced microspacecraft from Scotland [PDF]

, 2008
The City of Glasgow is renowned for its engineering and technological innovation; famous Glaswegian inventors and academics include James Watt (Steam Engine) and John Logie Baird (television), amongst many others.
,, Clark, C., McInnes, C., Radice, G.
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The space station: Human factors and productivity [PDF]

Human factor researchers and engineers are making inputs into the early stages of the design of the Space Station to improve both the quality of life and work on-orbit.
Burns, M. J., Gillan, D. J., Nicodemus, C. L., Smith, R. L.   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source